A Brief Review on Rational Consideration of Fixed Dose Combinations

Chandel, Satish; Joshi, Abhay; Sonawane, Rakesh; Jain, Nidhi

doi:10.15373/22778179/june2014/101

Cited by 2 publications

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“…In March 2016, 344 FDCs were categorized as irrational and banned 6 . According to the national list of essential medicines in 2015, it contains 19 FDC 4 . In order to promote rational use of medicines, the World health organization has implemented a concept of an essential drug list for the first time in 1977 and its regular updates of the model essential drug list for every two years 8 .…”

Section: E-mail: Jubincherian1@gmailcommentioning

confidence: 99%

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2020

IJPSR

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Fixed-dose combinations are defined as a combination of two or more active ingredients in a fixed ratio of doses. Recently fixed-dose combinations are more rapidly marketed; the available combinations in the market include both rational and irrational. The use of irrational fixed-dose combinations has resulted in severe adverse drug reactions and a reduction in patient quality of life. The main objective of this study was to assess the prescribing patterns and rationality of fixed-dose combinations in a tertiary care teaching hospital. A prospective and observational study was conducted in 249 inpatients after taking written consent from those who meet study criteria in the Medicine and Pediatric department for a period of 6 months. In this study, the combinations of drugs were equally distributed to both females and males patients (50%), most patients were in the age group of 70-79 (20%). A total of 355 combinations of drugs were used belonging to 48 different combinations. The most commonly prescribed combinations were Aspirin + Atorvastatin (13%) and Tramadol + Acetaminophen (12%). Out of which, 3 drug combinations were found to be banned accordingly to CDSCO Guidelines and WHO essential list of medicines. The rationality was assessed using 7 point criteria with a maximum scoring of 14.7 FDCs scored 0-8, 10 scored 9 to 11 and 31 scored 12 to 14. This result indicated that the majority of fixed-dose combinations used were rational.

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Section: E-mail: Jubincherian1@gmailcommentioning

confidence: 99%

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2020

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“…The FDCs can be divided into rational or irrational. 5 Rational drug use is conventionally defined as "patients receive medication appropriate to their clinical needs, in doses that meet their requirements, for an adequate period of time, and at the lowest cost to them and their community. 6 The trend of prescribing FDCs is increasing in clinical practice.…”

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A survey to assess awareness about fixed dose combinations (FDCs) among pharmacists in two Central Kashmir Districts, Srinagar and Budgam, Kashmir, India

Mir

2017

Int J Basic Clin Pharmacol

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Background: FDCs are highly popular in Indian pharmaceutical market. The FDCs have both advantages as well as disadvantages. To be advantageous WHO guidelines for the manufacture and use of FDCs must be strictly followed. Irrational use of FDCs is a major public health problem and leads to increased risk of adverse drug events, higher treatment costs and antimicrobial resistance. FDCs as well as other single component drugs cannot be used rationally unless everyone involved directly or indirectly in the health care profession is involved. Pharmacist is a coordinator between different members of healthcare team and the patients. Hence, his role in safe use of medicines is important. The present study was undertaken to assess the knowledge of pharmacists about FDCs. Methods: A descriptive questionnaire survey was conducted in various government and private pharmacies of two Central Kashmir Districts, Srinagar and Budgam, aiming to assess the knowledge of pharmacists about FDCs. The questionnaires were distributed randomly among 79 pharmacists, out of which 60 returned the completed questionnaire. Results: 55.00% of the respondents knew the basic facts about FDCs. 96.66% knew that FDCs reduced the cost of therapy and 93.33% were aware that FDCs improve patient compliance. 60% answered incorrectly when asked about effect of FDCs on cumulative toxicity. Almost equal percentage (63.33%) answered incorrectly when asked about rationality and ADR profile of FDCs. 83.33% knew that it is difficult to know the offending agent in case ADRs occur after FDC use.78.33% respondents thought that all FDCs are approved by drug regulatory authorities. Conclusions: The study showed that pharmacists had not the enough knowledge about FDCs. Pharmacy students in their formative years of learning should be taught to promote rational use of FDCs as they are the future custodians of technical information on the products available on their domestic market.

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A Brief Review on Rational Consideration of Fixed Dose Combinations

Cited by 2 publications

References 1 publication

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A survey to assess awareness about fixed dose combinations (FDCs) among pharmacists in two Central Kashmir Districts, Srinagar and Budgam, Kashmir, India

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