A Brief Review on Herbal Medicines

Matole, Vinod; Thorat, Yogesh; Ghurghure, Shrishail M.; Ingle, Suyash; Birajdar, Avinash; Nangare, Gajanand; Safwan, Moulavi; Madur, Saili; Patil, Smeeta; Bagalkote, Zainab; Sakhare, Aishwarya

doi:10.52711/0975-4385.2021.00016

Cited by 13 publications

(5 citation statements)

References 2 publications

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“…The World Health Organization (WHO) declares that 80% of the populations of Asian and African countries still widely use herbal medicine as first-line treatment. 31 Additionally, herbal medicines are safe and efficacious as per individual testimonials. 32 In this regard, Indonesia is rich, with more than 1,000 plants growing in the distribution area.…”

Section: Activation Application Of Raw 2647 In Zingiberaceaementioning

confidence: 99%

RAW 264.7 Macrophage Cell Line: In Vitro Model for the Evaluation of the Immunomodulatory Activity of Zingiberaceae

2023

TJNPR

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The immune response plays an essential role in the body's defense against infection. Macrophages are promising targets against which to screen agents that modulate immune responses. In vitro analysis, primarily using cell lines, is preferred to screen bioactivity initially. RAW 264.7 cells comprise a model macrophage cell line close to primary murine macrophages. Indonesian people often use the Zingiberaceae family or “empon-empon" in the favorable treatment of several diseases, including immune disorders. This review highlights several studies of Zingiberaceae using RAW 264.7 cells, focusing on the observed immunomodulatory activity and assay methods. The research on RAW 264.7 macrophage cell line in Zingiberaceae was gathered using Scopus, PubMed, ScienceDirect, and Google Scholar from 2012-2021. Based on the reviews, the Zingiberaceae family has immunomodulatory effects by increasing or decreasing inflammatory mediators such as NO, IL-6, TNF-α, IL-1β, IL-10, and phagocytosis activity in RAW 264.7 cells. Several methods can assess the activation of RAW 264.7 cells, including cell viability assays using 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT); measuring nitric oxide production (Griess reaction), cytokine production (enzyme-linked immunosorbent assay [ELISA]), and phagocytosis (neutral red uptake assay); and detecting DNA (real-time quantitative polymerase chain reaction [qPCR]). The information provided in this review presents avenues for future investigations of the immunomodulatory activity of Zingiberaceae.

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Section: Activation Application Of Raw 2647 In Zingiberaceaementioning

confidence: 99%

RAW 264.7 Macrophage Cell Line: In Vitro Model for the Evaluation of the Immunomodulatory Activity of Zingiberaceae

2023

TJNPR

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“…This is due to the widespread perception that herbal medicines have no side effects and are inexpensive and readily available. (3)(4)(5) Chemical drug side effects, scepticism of allopathic medicine's methodologies and assumptions, rising costs, and improved public access to knowledge on the safety and usefulness of medicinal plants have all contributed to a surge in interest in medicinal plants. When people try home remedies for acute, self-limiting diseases such as a cold, throat infection, or bee sting, it's typically because expert help is unreachable immediately, or it's too inconvenient, costly, or time taking.…”

Section: Standardization Evaluation and Quantification Of Herbal Drug...mentioning

confidence: 99%

Standardization, evaluation and quantification of herbal drugs by various analytical methods

Manani¹,

Raval²,

Chandarana³

et al. 2022

IJAM

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This review article encompasses the various evaluation parameters of standardization of different medicinal plants and its constituents. In today’s life, more and more people of the world are turning towards the use of natural or herbal products as these have very less or negligible side effects. As the use of herbal medicinal products is increasing day by day, the questions regarding their quality are also arising. This is due to lack of parameters for the standardization of these products. There is a need to set different parameters or methods that can help to standardize the herbal medicinal plant materials. Various methods like physical, chemical, biological is used for standardization and quality evaluation of herbal medicinal plants. These methods can act as a basic tool for the quality evaluation of herbal plant materials. Different parameters of standardization are the fundamental tool for evaluating and assuring the quality of the herbal plant material and its products. This review article includes the quantitative evaluation of more than 20 herbal drugs. The evaluation parameters such as TLC, HPLC, HPTLC, GC, LC-MS, UPLC, UHPLC, UPLC-MS, UHPLC-MS will help to maintain quality of different herbal medicinal drugs as well as its formulations. The set parameters can ultimately lead to the quality and efficacy of the herbal medicinal formulations. Analytical methods and standardization can ensure the quality and consistency of active ingredients in herbal medicinal formulations.

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“…Phytopreparations can prolong the therapeutic effects of drugs, which is especially important for long-term use in chronic diseases, including gastric ulcers [13][14][15][16][17]. However, plant remedies (in terms of the strength and speed of their effect) cannot fully replace synthetic drugs; therefore, they can be used as an auxiliary or additional therapy in the complex treatment of gastrointestinal tract diseases [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Coumarins of Ferulopsis hystrix: LC–MS Profiling and Gastroprotective and Antioxidant Activities of Skimmin and Peucenidin

Razuvaeva,

Toropova,

Salchak

et al. 2023

Applied Sciences

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Ferulopsis hystrix is a perennial plant of the Apiaceae family. In Buryat and Mongolian medicine, it is used as a substitute for Costus speciosus roots (ru rta), and in Tibetan medicine, it is used to cure digestive system diseases and used as a wound-healing agent. However, its metabolites and their bioactivities are still poorly understood. High-performance liquid chromatography with photodiode array detection and electrospray ionization triple quadrupole mass-spectrometric detection (HPLC–PDA–ESI–tQ–MS/MS) were used to identify approximately 42 phenolic compounds in F. hystrix, and 30 coumarins were characterized and quantified. The major compounds in F. hystrix roots were skimmin (umbelliferone 7-O-glucoside) and peucenidin (vaginidiol 3′-O-acetyl-4′-O-senecioyl ester), of which, gastroprotective and antioxidant effects were found for the first time. The abovementioned compounds exhibit a gastroprotective effect against indomethacin and steroid gastropathy by reducing the amount of damage (point, large, and strip-like erosions) in the gastric mucosa and lowering the corresponding Paul’s index. The most pronounced gastroprotective effect was exhibited by skimmin at a dose of 1 mg/kg and by peucenidin at doses of 16 and 48 mg/kg; these compounds help to limit the development of pronounced erosive–necrotic processes in the gastric mucosa. In pathological conditions, these compounds reduce malondialdehyde, increase the activity of catalase, and increase the content of reduced glutathione in the blood. Thus, this study demonstrates that F. hystrix roots are a good source of bioactive coumarins with gastroprotective potential, which supports earlier ethnopharmacological studies.

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A Brief Review on Herbal Medicines

Cited by 13 publications

References 2 publications

RAW 264.7 Macrophage Cell Line: In Vitro Model for the Evaluation of the Immunomodulatory Activity of Zingiberaceae

RAW 264.7 Macrophage Cell Line: In Vitro Model for the Evaluation of the Immunomodulatory Activity of Zingiberaceae

Standardization, evaluation and quantification of herbal drugs by various analytical methods

Coumarins of Ferulopsis hystrix: LC–MS Profiling and Gastroprotective and Antioxidant Activities of Skimmin and Peucenidin

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