A Brief Review on Advantages of Nano-based Drug Delivery Systems

Hami, Zahra

doi:10.5812/amh.112274

Cited by 18 publications

(9 citation statements)

References 62 publications

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“…[9,10] Within this overarching context, nanotechnology has materialized as a propitious enabler in the field of drug delivery, as evidenced by a surge in investigations related to nano-drug delivery systems (NDDSs). [11] NDDSs, owing to their nanoscale proportions, boast heightened biocompatibility, augmented bioavailability, and the ability to target drug delivery [13,14] precisely. The incorporation of nanoparticles into nanocomposites often serves to enhance the aqueous solubility of poorly soluble drugs.…”

Section: Introductionmentioning

confidence: 99%

A Data Mining Study of Zinc Oxide Nanostructures Utilization in Drug Delivery Nanosystems

Valladão,

da Silva,

Souza

2024

Macromolecular Symposia

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The present investigation offers a thorough bibliometric exploration spotlighting the pivotal utilization of zinc oxide nanostructures, encompassing both zero‐dimensional (0D) nanoparticles and one‐dimensional (1D) nanostructures, within the realm of nanotechnology‐driven drug delivery systems. This analysis particularly illuminates the distinctive potential of these nanostructures in the cancer therapy context, not merely as carriers and deliverers of pharmaceutical agents, but as entities capable of selectively inducing apoptosis in cancer cells through the orchestrated generation of reactive oxygen species (ROS). Recent research endeavors notably underscore the application prospects of ZnO nanostructures in domains like DNA cleavage, bioimaging, and agricultural defense mechanisms. Moreover, the study elucidates the pronounced enhancement in solubility and biocompatibility that these nanostructures bring about when harmoniously integrated into polymeric nanocomposites. Concomitantly, the involvement of polymers in this symbiotic system is unveiled, wherein they play a multifaceted role in dictating release selectivity, thereby facilitating targeted and efficacious interactions with tissues. Functionally engineered polymeric nanocomposites emerge as promising candidates for targeted delivery modalities in cancer treatment, demonstrating an affinity for specific cell receptors and exhibiting enhanced cellular uptake within the size range of 100–200 nm. The study unearths robust associations among pivotal research terminologies through an exhaustive analysis of Link Strength Between Items (LSBI), culminating in the presentation of a cogent map delineating the evolving trends and forthcoming trajectories in this dynamic domain. In summation, this all‐encompassing bibliometric inquiry serves as a poignant testament to the prodigious potential of zinc oxide nanostructures in the realm of forthcoming nanotechnology‐driven drug delivery paradigms.

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Section: Introductionmentioning

confidence: 99%

A Data Mining Study of Zinc Oxide Nanostructures Utilization in Drug Delivery Nanosystems

Valladão,

da Silva,

Souza

2024

Macromolecular Symposia

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“…Nanomaterials have small sizes that vary between 1 and 100 nm, and high surface area to volume ratio. Therefore, nano-based drug delivery systems provide better absorption, bioavailability and stability than other known drug delivery systems [15]. Selenium nanoparticles are a subject of interest in nanomedicine for multiple reasons.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective role of selenium nanoparticles against behavioral, neurobiochemical and histological alterations in rats subjected to chronic restraint stress

Elfakharany,

Eskaros,

Azhary

et al. 2024

Preprint

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Chronic stress induces changes in the prefrontal cortex and hippocampus. Selenium nanoparticles (SeNPs) showed promising results in several neurological animal models. The implementation of SeNPs in chronic restraint stress (CRS) remains to be elucidated. This study was done to determine the possible protective effects of selenium nanoparticles on behavioral changes and brain oxidative stress markers in a rat model of chronic restraint stress. 50 rats were divided into three groups; control group (n = 10), untreated CRS group (n = 10) and CRS-SeNPs treated group (n = 30). Restraint stress was performed 6 hrs./day for 21 days. Rats of CRS-SeNPs treated group received 1, 2.5 or 5 mg/kg SeNPs (10 rats each) by oral gavage for 21 days. Rats were subjected to behavioral assessments and then sacrificed for biochemical and histological analysis of the prefrontal cortex and hippocampus. Prefrontal cortical and hippocampal serotonin levels, oxidative stress markers including malondialdehyde (MDA), reduced glutathione (GSH) and glutathione peroxidase (GPx), tumor necrosis factor alpha (TNF-α) and caspase-3 were assessed. Accordingly, Different doses of SeNPs showed variable effectiveness in ameliorating disease parameters, with 2.5 mg/kg dose of SeNPs showing the best improving results in all studied parameters. The present study exhibited the neuroprotective role of SeNPs in rats subjected to CRS and proposed their antioxidant, anti-inflammatory and anti-apoptotic effects as the possible mechanism for increased prefrontal cortical and hippocampal serotonin level, ameliorated anxiety-like and depressive-like behaviors and improved prefrontal cortical and hippocampal histological architecture.

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“…[4,5] NP-based drug delivery systems (DDSs) have several advantages compared to traditional methods of administering therapeutic agents. [6] Despite DOI: 10.1002/smll.202305375 the widespread use of drugs as a treatment for diseases, clinical trials have shown limited efficacy due to low accumulation in target cells, rapid clearance, and the potential for adverse reactions due to supplement overdose. [7,8] The utilization of NPs can improve the pharmacological properties of small-molecule drugs, including increasing aqueous solubility, improved bioavailability, and reducing adverse side effects.…”

Section: Introductionmentioning

confidence: 99%

Machine Learning Reinforced Genetic Algorithm for Massive Targeted Discovery of Selectively Cytotoxic Inorganic Nanoparticles

Jyakhwo,

Serov,

Dmitrenko

et al. 2023

Small

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Nanoparticles (NPs) have been employed as drug delivery systems (DDSs) for several decades, primarily as passive carriers, with limited selectivity. However, recent publications have shed light on the emerging phenomenon of NPs exhibiting selective cytotoxicity against cancer cell lines, attributable to distinct metabolic disparities between healthy and pathological cells. This study revisits the concept of NPs selective cytotoxicity, and for the first time proposes a high‐throughput in silico screening approach to massive targeted discovery of selectively cytotoxic inorganic NPs. In the first step, this work trains a gradient boosting regression model to predict viability of NP‐treated cell lines. The model achieves mean cross‐validation (CV) Q2 = 0.80 and root mean square error (RMSE) of 13.6. In the second step, this work develops a machine learning (ML) reinforced genetic algorithm (GA), capable of screening >14 900 candidates/min, to identify the best‐performing selectively cytotoxic NPs. As proof‐of‐concept, DDS candidates for the treatment of liver cancer are screened on HepG2 and hepatocytes cell lines resulting in Ag NPs with selective toxicity score of 42%. This approach opens the door for clinical translation of NPs, expanding their therapeutic application to a wider range of chemical space of NPs and living organisms such as bacteria and fungi.

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A Brief Review on Advantages of Nano-based Drug Delivery Systems

Cited by 18 publications

References 62 publications

A Data Mining Study of Zinc Oxide Nanostructures Utilization in Drug Delivery Nanosystems

A Data Mining Study of Zinc Oxide Nanostructures Utilization in Drug Delivery Nanosystems

Neuroprotective role of selenium nanoparticles against behavioral, neurobiochemical and histological alterations in rats subjected to chronic restraint stress

Machine Learning Reinforced Genetic Algorithm for Massive Targeted Discovery of Selectively Cytotoxic Inorganic Nanoparticles

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