A brief review of the immunobiology of
            <i>Eledone cirrhosa</i>

Malham, S.K.; Runham, NW

doi:10.2989/025776198784126304

Cited by 22 publications

(10 citation statements)

References 26 publications

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“…However, it was described in E. cirrhosa that injection of Vibrio anguillarum caused an increase in lysozyme activity in the branchial heart without changes in the activity of this enzyme in the haemolymph, while also reduced plasma antiprotease activity (Malham et al, 1998b), coinciding with our results in all three species. E. cirrhosa has a well develop immune system in the haemolymph, with bacteriostatic, lysozyme, protease, antiprotease and peroxidase activities, as seen by our results and as described by other authors (Malham and Runham, 1998). It was also described for this species that repeated sampling of haemolymph induced an increase in the haemocytes (Malham et al, 1998a).…”

Section: Discussionsupporting

confidence: 91%

“…The immune system in cephalopods is poorly known to date, and lacks an adaptive immune response, but shows a good and efficient innate immune system composed of cellular and humoral (dissolved proteins in plasma) defense factors (Castellanos-Martinez et al, 2014). Thus, lysozyme activity appears to act non-specifically against a wide range of invaders in E. cirrhosa (Malham et al, 1998b), peroxidases possess antimicrobial activity that eliminates H 2 O 2 , maintaining the redox balance of the immune system (Rodríguez et al, 2003), antiproteases protect against bacterial proteases as well as endogenous proteases released by host cells (Malham and Runham, 1998; Malham et al, 1998b), while proteases like anti-trypsin show anti-inflammatory activity (Guttman et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Acute-Stress Biomarkers in Three Octopodidae Species After Bottom Trawling

et al. 2019

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Several Octopodidae species have a great potential for the diversification of worldwide aquaculture. Unfortunately, the lack of stress-related biomarkers in this taxon results an obstacle for its maintenance in conditions where animal welfare is of paramount relevance. In this study, we made a first approach to uncover physiological responses related to fishing capture in Eledone moschata , Eledone cirrhosa , and Octopus vulgaris . Captured octopus from all three species were individually maintained in an aquaculture system onboard of oceanographic vessel in south-western waters of Europe. Haemolymph plasma and muscle were collected in animals at the moment of capture, and recovery was evaluated along a time-course of 48 h in Eledone spp., and 24 h for O. vulgaris . Survival rates of these species captured in spring and autumn were evaluated. Physiological parameters such as plasma pH, total CO 2 , peroxidase activity, lysozyme, hemocyanin, proteases, pro-phenoloxidase, anti-proteases, free amino acids, lactate and glucose levels, as well as muscle water percentage, free amino acids, lactate, glycogen and glucose values were analyzed. The immune system appears to be compromised in these species due to capture processes, while energy metabolites were mobilized to face the acute-stress situation, but recovery of all described parameters occurs within the first 24 h after capture. Moreover, this situation exerts hydric balance changes, as observed in the muscle water, being these responses depending on the species assessed. In conclusion, three Octopodidae species from south-western waters of Europe have been evaluated for stress-related biomarkers resulting in differentiated mechanisms between species. This study may pave the way to further study the physiology of stress in adult octopuses and develop new methodologies for their growth in aquaculture conditions.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Acute-Stress Biomarkers in Three Octopodidae Species After Bottom Trawling

et al. 2019

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“…In the branchial heart these cells, together with the predominant ovoid cells, form part of a comprehensive defense and detoxification system (Guary et al 1981;Budelmann et al 1997;Malham et al 1997;Malham and Runham 1998;Beuerlein et al 2002). The ovoid cells have been termed "rhogocytes" in Octopus joubini Rob.…”

Section: Introductionmentioning

confidence: 97%

Hemocyanin and the branchial heart complex of Sepia officinalis : are the hemocytes involved in hemocyanin metabolism of coleoid cephalopods?

Beuerlein

Ruth

Westermann

et al. 2002

Cell and Tissue Research

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Cytobiological experiments using isotopic- and cytochemical-labeled Sepia hemocyanin as well as immunocytochemical localization of the respiratory pigment were carried out to investigate the function of the hemocytes in hemocyanin metabolism of the common cuttlefish Sepia officinalis. For comparison, the rhogocytes (ovoid cells) of the branchial heart complex were included in this study. Hemocyanin molecules were immunocytochemically detected in the lysosomal compartment of the rhogocytes and, at lower levels, in adhesive and circulating hemocytes. (125)I-labeled Sepia hemocyanin was taken up by the rhogocytes only, whereas gold- and/or fluorescein-labeled Sepia hemocyanin was solely taken up by the adhesive and the circulating hemocytes, even though the level of uptake is different. There are also differences in the uptake of pure gold particles and/or fluorescein between rhogocytes and hemocytes. These findings give evidence that circulating and adhesive hemocytes of the branchial heart complex are not involved in hemocyanin turnover, but are a component of the cellular defense and detoxification system of adult coleoid cephalopods.

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“…Haemocytes are crucial in the cephalopod immune response [51,52,53]. Although these cells are vital to maintain the wellbeing in all different cephalopod species, the studies conducted about haemocytes are limited, and most of the observations have been performed on octopus species [45,50,54,55,56,57,58] with few descriptions available on Euprymna scolopes [59] and Sepia officinalis [46,60,61].…”

Section: Type and Number Of Haemocytes In The Cephalopods Haemolymphmentioning

confidence: 99%

“…The concentration of haemocytes in circulating haemolyph is an important parameter since it may be used as a biomarker of immune response capability and reflects the welfare of the individuals, as had been stated in other mollusks [65,66]. Specific data concerning changes in haemocyte concentration after injury or experimental pathogen injection have been published in O. vulgaris [57,71], E. cirrhosa [52,53] and S. officinalis…”

Section: Type and Number Of Haemocytes In The Cephalopods Haemolymphmentioning

confidence: 99%

Understanding the cephalopod immune system based on functional and molecular evidence

Gestal

Castellanos-Martínez

2015

Fish & Shellfish Immunology

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Cephalopods have the most advanced circulatory and nervous system among the mollusks. Recently, they have been included in the European directive which state that suffering and pain should be minimized in cephalopods used in experimentation. The knowledge about cephalopod welfare is still limited and several gaps are yet to be filled, especially in reference to pathogens, pathologies and immune response of these mollusks. In light of the requirements of the normative, in addition to the ecologic and economic importance of cephalopods, in this review we update the work published to date concerning cephalopod immune system. Significant advances have been reached in relation to the characterization of haemocytes and defensive mechanisms comprising cellular and humoral factors mainly, but not limited, in species of high economic value like Sepia officinalis and Octopus vulgaris. Moreover, the improvement of molecular approaches has helped to discover several immune-related genes/proteins. These immune genes/proteins include antimicrobial peptides, phenoloxidases, antioxidant enzymes, serine protease inhibitor, lipopolysaccharide-induced TNF-α factor, Toll-like receptors, lectins, even clusters of differentiation among others. Most of them have been found in haemocytes but also in gills and digestive gland, and the characterization as well as their precise role in the immune response of cephalopods is still pending to be elucidated. The assessment of immune parameters in cephalopods exposed to contaminants is just starting, but the negative impact of some pollutants on the immune response of the common octopus has been reported. This review summarizes the current status of our knowledge about the cephalopod immune system that seems to be far from simply. On the contrary, the advances gained to date point out a complex innate immunity in cephalopods.

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A brief review of the immunobiology of Eledone cirrhosa

Cited by 22 publications

References 26 publications

Acute-Stress Biomarkers in Three Octopodidae Species After Bottom Trawling

Acute-Stress Biomarkers in Three Octopodidae Species After Bottom Trawling

Hemocyanin and the branchial heart complex of Sepia officinalis : are the hemocytes involved in hemocyanin metabolism of coleoid cephalopods?

Understanding the cephalopod immune system based on functional and molecular evidence

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