A brief review of techniques used to seal corneal perforation using cyanoacrylate tissue adhesive

Rana, Mrinal; Savant, Vijay

doi:10.1016/j.clae.2013.03.006

Cited by 27 publications

(18 citation statements)

References 5 publications

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“…While fast polymerization makes the process of sealing time-efficient and minimizes discomfort to the patient, it also complicates its application for the physician. For instance, in cornea perforation sealing, it is important to control the moisture of the tissue surface, and to rapidly apply a proper dose of cyanoacrylate so that a thin and even layer of the cyanoacrylate polymerizes in place to hold the tissue effectively [50]. Given these challenges, the selection of the proper technique for the application of cyanoacrylate-based adhesives in a particular intervention becomes critical for a successful clinical outcome.…”

Section: Cyanoacrylate-based Ocular Adhesivesmentioning

confidence: 99%

“…Given these challenges, the selection of the proper technique for the application of cyanoacrylate-based adhesives in a particular intervention becomes critical for a successful clinical outcome. Rana et al summarized different techniques to apply cyanoacrylate glues in corneal perforations [50]. The traditional Fig.…”

Section: Cyanoacrylate-based Ocular Adhesivesmentioning

confidence: 99%

“…(B) Cyanoacrylate based glue applications, (i) traditional technique: direct application of a drop of cyanoacrylate glue on a pre-dried ocular tissue, and (ii) patient eye treated with this technique; (iii) infant cannula technique: a small disc of a non-adhesive material is cut with a punch biopsy, an infant cannula (without needle) is used to pick up and hold the disc, a drop of glue is applied on the disc, and finally the glue is placed gently on the pre-dried ocular tissue, (iv) patient eye treated with this technique, (v) corneal tissue repaired with this technique. Adapted from Rana et al [50] with permission from Elsevier, copyright 2013. (C) A polyglactin mesh glued with cyanoacrylate on a cadaver eye for strabismus surgery application, and effect of the polymerization time and surface area on the bonding strength of the mesh to the eye tissue.…”

Section: Cyanoacrylate-based Ocular Adhesivesmentioning

confidence: 99%

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Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

et al. 2019

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Closure of ocular wounds after an accident or surgery is typically performed by suturing, which is associated with numerous potential complications, including suture breakage, inflammation, secondary neovascularization, erosion to the surface and secondary infection, and astigmatism; for example, more than half of post-corneal transplant infections are due to suture related complications. Tissue adhesives provide promising substitutes for sutures in ophthalmic surgery. Ocular adhesives are not only intended to address the shortcomings of sutures, but also designed to be easy to use, and can potentially minimize post-operative complications. Herein, recent progress in the design, synthesis, and application of ocular adhesives, along with their advantages, limitations, and potential are discussed. This review covers two main classes of ocular adhesives: (1) synthetic adhesives based on cyanoacrylates, polyethylene glycol (PEG), and other synthetic polymers, and (2) adhesives based on naturally derived polymers, such as proteins and polysaccharides. In addition, different technologies to cover and protect ocular wounds such as contact bandage lenses, contact lenses coupled with novel technologies, and decellularized corneas are discussed. Continued advances in this area can help improve both patient satisfaction and clinical outcomes.

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Section: Cyanoacrylate-based Ocular Adhesivesmentioning

confidence: 99%

Section: Cyanoacrylate-based Ocular Adhesivesmentioning

confidence: 99%

Section: Cyanoacrylate-based Ocular Adhesivesmentioning

confidence: 99%

See 1 more Smart Citation

Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

et al. 2019

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“…Within 48 h of presentation, superior corneal thinning was noted which subsequently perforated on day 7, post CXL treatment. Corneal gluing was performed with cyanoacrylate glue using the modified technique [4] (Figs. 2 and 3).…”

Section: Post Proceduresmentioning

confidence: 99%

“…Corneal scrapes isolated colonies of Methicillin Resistant Staphylococcus aureus (MRSA). Unfortunately, within 48 h of presentation, the cornea perforated and the patient had to undergo corneal gluing as per modified technique [4]. Over the subsequent weeks, he made good recovery from this infective episode.…”

Section: Post Proceduresmentioning

confidence: 99%

Severe microbial keratitis and associated perforation after corneal crosslinking for keratoconus

Rana

Lau

Aralikatti

et al. 2015

Contact Lens and Anterior Eye

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Dopamine‐Based High‐Transparent Hydrogel as Bioadhesive for Sutureless Ocular Tissue Repair

Qian

Shen

et al. 2023

Adv Funct Materials

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Ocular injuries and their complications represent the most common causes of visual impairment. For ocular surgery, there is an unmet need for highly transparent bioadhesives with superior adhesion, biocompatibility, and regenerative properties. Herein, a novel high‐transparent bioadhesive hydrogel composed of gelatin methacryloyl (GelMA) and dopamine methacrylamide (DMA) is developed by in situ oxidative free‐radical polymerization. This bioadhesive hydrogel overcomes the fundamental weakness of mussel‐inspired adhesive copolymers in clinical practice by combining multiple favorable properties, including high light transmission, mechanical strength, adhesive strength, and biocompatibility. DMA significantly enhances corneal epithelial cells adhesion, proliferation, and migration on GelMA, and prevents the accumulation of reactive oxygen species (ROS) in corneal epithelial cells. In rabbit models of corneal and conjunctiva transplantation, the bioadhesive is able to decrease the inflammatory response and fibrosis formation induced by suture surgical trauma. In addition, the rabbit corneal stromal defect model reveals that the Gel/DMA bioadhesive could effectively seal corneal defects, accelerates corneal re‐epithelialization, and promotes wound healing. Thus, given the advantages of high bioactivity and simple preparation, the Gel/DMA bioadhesive represents a promising strategy for suture‐free ocular repair.

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A brief review of techniques used to seal corneal perforation using cyanoacrylate tissue adhesive

Cited by 27 publications

References 5 publications

Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

Severe microbial keratitis and associated perforation after corneal crosslinking for keratoconus

Dopamine‐Based High‐Transparent Hydrogel as Bioadhesive for Sutureless Ocular Tissue Repair

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