A brief review of novel nucleic acid test biosensors and their application prospects for salmonids viral diseases detection

Abstract

Viral diseases represent one of the major threats for salmonids aquaculture. Early detection and identification of viral pathogens is the main prerequisite prior to undertaking effective prevention and control measures. Rapid, sensitive, efficient and portable detection method is highly essential for fish viral diseases detection. Biosensor strategies are highly prevalent and fulfill the expanding demands of on-site detection with fast response, cost-effectiveness, high sensitivity, and selectivity. With the development of material science, the nucleic acid biosensors fabricated by semiconductor have shown great potential in rapid and early detection or screening for diseases at salmonids fisheries. This paper reviews the current detection development of salmonids viral diseases. The present limitations and challenges of salmonids virus diseases surveillance and early detection are presented. Novel nucleic acid semiconductor biosensors are briefly reviewed. The perspective and potential application of biosensors in the on-site detection of salmonids diseases are discussed.

Preface to Special Issue on Novel Semiconductor-biochemical Sensors

“…Strategies such as reducing the biotoxicity of QDs, enabling high-scale QDs preparation, and incorporating the nucleic acid free-extraction method are promising to satisfy the demand for virus de-tection in times of pandemics. Zheng et al summarized the advances of semiconductor biosensors based on graphene, carbon nanotube and silicon nanowire for detection of viral zoonoses [2] . They focused on the working principles, design directions and application prospects of the biosensors.…”