A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi

Abstract

Deep-sea fungi, the fungi that inhabit the sea and the sediment at depths of over 1000 m below the surface, have become an important source of industrial, agricultural, and nutraceutical compounds based on their diversities in both structure and function. Since the first study of deep-sea fungi in the Atlantic Ocean at a depth of 4450 m was conducted approximately 50 years ago, hundreds of isolates of deep-sea fungi have been reported based on culture-dependent methods. To date more than 180 bioactive secondary metabolites derived from deep-sea fungi have been documented in the literature. These include compounds with anticancer, antimicrobial, antifungal, antiprotozoal, and antiviral activities. In this review, we summarize the structures and bioactivities of these metabolites to provide help for novel drug development.

Myrmecridium hiemale sp. nov. from snow-covered alpine soil is the first eurypsychrophile in this genus of anamorphic fungi

“…Interest in psychrophilic organisms has increased in recent years, as shown by the large number of new taxa of cold-adapted prokaryotes and fungi described in the last years (Buzzini & Margesin, 2014;Margesin et al, 2009;Wang et al, 2015). However, little research has focused on the biodiversity of organisms growing in snow-covered soil, and most studies are based on molecular data only (Kuhnert et al, 2012;Zinger et al, 2009).…”

“…They have developed particular physiological modifications, for example in enzyme activity, membrane fluidity and transport, as well as cold denaturation of proteins in order to survive and proliferate at low temperatures (D'Amico et al, 2006). Therefore, cold-adapted fungi have become important sources for the discovery of novel bioactive secondary metabolites and enzymes (Margesin & Fell, 2008;Margesin et al, 2009;Wang et al, 2015).…”

Cytoglobosins H and I, New Antiproliferative Cytochalasans from Deep-Sea-Derived Fungus Chaetomium globosum

“…Furthermore, secondary metabolites from deep-sea fungus, with antimicrobial, antifungal, cytotoxic, antiviral, and antiprotozoal activities, have been well studied during recent decades [2,3]. The genus Chaetomium , which includes both terrestrial- and marine-derived species, is well-known for producing structurally complex natural products with antioxidant, antimicrobial, and cytotoxic bioactivities [4,5,6,7,8].…”

Isolation of Bioactive Metabolites Producing Fungal Strains From Milk Products and Milk Industries of Raipur District

“…[1] These compounds found profound use as antibiotics against a wide variety of infectious diseases such as Diabetes, HIV-1, Hepatitis A, B, etc. Drugs such as cephalosporin, penicillin, vancomycin and streptomycin, etc are extremely effective against multiple bacterial infections.…”