A Brief Overview of How Male Medicine Co-opted the Birth Process

Vernon, Leonard F.

doi:10.19104/whi.2015.108

Cited by 1 publication

(1 citation statement)

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“…Accessing underrepresented patient groups who have been historically abused or manipulated by the medical community is particularly challenging. [ 46 ] More effort must be invested in patient education to increase trust and improve diverse participation in research. [ 1 ] Beyond acquisition of tissue and organoids, researchers must have access to demographic data (age, sex, race, genetic ancestry, socioeconomic status, etc.)…”

Section: Implementing Intestinal Organoids To Capture Diversity In Vitromentioning

confidence: 99%

Toward Inclusivity in Preclinical Drug Development: A Proposition to Start with Intestinal Organoids

Co¹,

Klein²,

Kang³

et al. 2023

Advanced Biology

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Representation of humans from diverse backgrounds in the drug development process is key to advancing health equity, and while clinical trial design has recently made strides toward greater inclusivity, preclinical drug development has struggled to make those same gains. One barrier to inclusion is the current lack of robust and established in vitro model systems that simultaneously capture the complexity of human tissues while representing patient diversity. Here, the use of primary human intestinal organoids as a mechanism to advance inclusive preclinical research is proposed. This in vitro model system not only recapitulates tissue functions and disease states, but also retains the genetic identity and epigenetic signatures of the donors from which they are derived. Thus, intestinal organoids are an ideal in vitro prototype for capturing human diversity. In this perspective, the authors call for an industry‐wide effort to leverage intestinal organoids as a starting point to actively and intentionally incorporate diversity into preclinical drug programs.

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Section: Implementing Intestinal Organoids To Capture Diversity In Vitromentioning

confidence: 99%