A Brief Introduction to the Exposome and Human Health

Functional consequences of lead and mercury exposomes in the heart

“…Professor Christopher Paul Wild defined the exposome as a concept that complements the genome and includes the entire external and internal environmental human exposure to non-genetic factors from conception until a certain age, and how it affects health and promotes disease (Wild, 2005(Wild, , 2012. The concept of exposome can be approximated by producing a system that estimates interacting natural or anthropogenic environmental pollutants that are epidemiologically relevant in space and time and that interact with each other and various ecosystems, resulting in environmental damage and specific harm to public health from conception to all ages (Chung et al, 2018;Lucock and Medicine, 2020;Tamayo-Uria et al, 2019). A useful epidemiological approach has been to measure reliable all of the relevant environmental variables of lead and mercury exposures using biomarkers, sensors, among others, and then to characterize the potential molecular effects of these heavy metal pollutants.…”