A Brief History of Sensation and Reward

Marks, Lawrence Ε.

doi:10.1201/b10776-4

Cited by 8 publications

(13 citation statements)

References 56 publications

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“…The last couple of decades has brought incredible scientific rigor to the question, with an ever‐growing number of behavioral, lesional, imaging, and electrophysiological studies demonstrating that the OFC encodes representations of value. Further, the neuroeconomical question of whether all values, rewards, and pleasures are commensurate, that is, differing only in quantity but not quality, importantly extends an ancient dialog stretching at least as far back as the Greek philosopher, Democritus (c. 460 to c. 370 BCE), who noted that “men get pleasure from scratching themselves: they feel an enjoyment like that of lovemaking.” 3 …”

Section: Introductionmentioning

confidence: 99%

The value of identity: olfactory notes on orbitofrontal cortex function

Gottfried

Zelano

2011

Annals of the New York Academy of Sciences

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Neuroscientific research has emphatically promoted the idea that the key function of the orbitofrontal cortex (OFC) is to encode value. Associative learning studies indicate that OFC representations of stimulus cues reflect the predictive value of expected outcomes. Neuroeconomic studies suggest that the OFC distills abstract representations of value from discrete commodities to optimize choice. Although value-based models provide good explanatory power for many different findings, these models are typically disconnected from the very stimuli and commodities giving rise to those value representations. Little provision is made, either theoretically or empirically, for the necessary cooperative role of object identity, without which value becomes orphaned from its source. As a step toward remediating the value of identity, this review provides a focused olfactory survey of OFC research, including new work from our lab, to highlight the elemental involvement of this region in stimulus-specific predictive coding of both perceptual outcomes and expected values.

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Section: Introductionmentioning

confidence: 99%

The value of identity: olfactory notes on orbitofrontal cortex function

Gottfried

Zelano

2011

Annals of the New York Academy of Sciences

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“…Two well-characterized affective hubs previously demonstrated to be gateways to parsimoniously engage prefrontal and corticolimbic networks through invasive means 21–24 are the ventral capsule/ventral striatum (VC/VS) and subcallosal cingulate (SCC). The VC/VS and SCC are thought to be hubs 25 at the crossroads of white matter pathways hypothesized to influence executive function 23 , reward processing 26,27 and mood processing 21,28 through their connections of varying degrees to prefrontal and limbic structures (spanning the amygdala, PFC and ACC) 29,30 with partial overlap 31–33 . Modulation of the two targets have shown promising results in DBS studies showing improvement in symptoms of anxiety 34 , depression 21,35,36 , treatment-refractory anorexia nervosa 37 , addiction 38–40 and obsessive compulsive disorder 41,42 .…”

Section: Introductionmentioning

confidence: 99%

Prefrontal network engagement by deep brain stimulation in limbic hubs

Allawala

Bijanki

Oswalt

et al. 2022

Preprint

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Frontotemporal circuits in the human brain play an important role in cognitive and affective processing. Neuromodulation therapies delivered to certain key hubs within these circuits are being used with increasing frequency to treat a host of neuropsychiatric disorders, but the detailed neurophysiological effects of stimulation are largely unknown. Here, we performed intracranial recordings across frontotemporal networks while delivering electrical stimulation to two well-established white matter hubs involved in cognitive regulation. We demonstrate a frontotemporal circuit consisting of the amygdala, lateral orbitofrontal cortex, and ventromedial prefrontal cortex in which gamma oscillations are differentially modulated depending on the target stimulated. We additionally highlight the heterogeneity in neural responses to stimulation across human subjects in other corticolimbic regions and demonstrate the capacity for further tuning of neural activity using current-steered stimulation. Our findings indicate a potential neurophysiological mechanism for the dissociable therapeutic effects seen across targets for neuromodulation and implications for future efforts in personalized, network-guided neurostimulation.

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“…The pleasure or rewarding value associated with sexual intercourse may not only exceed in magnitude that associated with scratching an itch, but the two pleasures or rewarding values may themselves be in addition qualitatively distinct. 13 There is evidence, in animals, of an increased dopaminergic activity in the VTA either from an unexpected reward or, after recognition of the reward characteristics, from the anticipation of the reward. Therefore, anticipation of a satisfaction activates neurochemical pleasure mechanisms and reinforces the obtaining behavior.…”

Section: -33mentioning

confidence: 99%

“…13 The biological basis of mood-related states, such as reward and aversion, is not yet fully understood, albeit it is recognized as a functional neuronal network. Classical formulations of these states implicate the mesocorticolimbic system, comprising brain areas that include the nucleus accumbens (NAc), the ventral tegmental area (VTA) and the prefrontal cortex, implicated reward; [14][15][16][17] and the amygdala (AMG), periaquaductal gray (PAG), and the locus coeruleus (LC), often implicated in aversion.…”

Section: 13mentioning

confidence: 99%

Reward and aversion systems of the brain as a functional unit. Basic mechanisms and functions

Michel-Chávez

Estañol-Vidal

Sentíes-Madrid

et al. 2015

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IntroductionIt is increasingly important to recognize the reward and aversion systems of the brain as a functional unit. A fundamental task of the mammalian brain is to assign an emotional/motivational valence to any stimuli by determining whether they are rewarding and should be approached or are aversive and should be avoided. Internal stimuli are also assigned an emotional/motivational valence in a similar fashion.

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A Brief History of Sensation and Reward

Cited by 8 publications

References 56 publications

The value of identity: olfactory notes on orbitofrontal cortex function

The value of identity: olfactory notes on orbitofrontal cortex function

Prefrontal network engagement by deep brain stimulation in limbic hubs

Reward and aversion systems of the brain as a functional unit. Basic mechanisms and functions

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