“…In 1840, Astley Paston Cooper described the finding of breast cancer cells in lymphatic vessels 3 , the first histological confirmation of lymph node metastasis. In 1847, Maximilian Joseph von Chelius, due to the poor prognosis of laryngeal cancers with lymphatic dissemination, claimed that it was impossible to control them 4,5 . In 1880, concerned about the findings of lymphatic dissemination, Theodor Kocher described the surgical removal of a tumor of the tongue in a block, along with lymphatic vessels, through a mandibulectomy 3 .…”