2020
DOI: 10.1007/s10068-020-00815-6
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A brief history and spectroscopic analysis of soy isoflavones

Abstract: The production of soybean continues to increase worldwide. People are showing more interest in the beneficial health effects of soybeans than before. However, the origin and history of soybeans are still being discussed among many researchers. Chromatographic methods enable the desirable separation of a variety of isoflavones from soybeans. The structures of isolated soy isoflavones have been successfully identified in tandem with spectroscopic analytical instruments and technologies such as liquid chromatogra… Show more

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Cited by 31 publications
(15 citation statements)
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References 93 publications
(167 reference statements)
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“…Isoflavone is a major compound isolated from soybeans; its pharmacological action has been established against cancers, osteoporosis, metabolic disorders, and neurodegenerative symptoms [ 41 ]. Furthermore, equol, as an isoflavone-derived metabolite, has diverse favorable therapeutic effects on human health, such as estrogenic and antioxidant efficacy [ 42 ].…”
Section: Discussionmentioning
confidence: 99%
“…Isoflavone is a major compound isolated from soybeans; its pharmacological action has been established against cancers, osteoporosis, metabolic disorders, and neurodegenerative symptoms [ 41 ]. Furthermore, equol, as an isoflavone-derived metabolite, has diverse favorable therapeutic effects on human health, such as estrogenic and antioxidant efficacy [ 42 ].…”
Section: Discussionmentioning
confidence: 99%
“…Not only that, the isoflavones also structurally resemble endogenous estrogens and have estrogenic activity by binding estrogen receptor ( 69 ). The primary natural source of isoflavones is soybean, containing various types of compounds, which are classified according to aglycones or modification by other functional groups, such as methoxylation and hydroxylation ( 70 ). Genistein, daidzein, and glycitein are the main representative compounds of isoflavones, which belong to soy phytoestrogens.…”
Section: Phytonutrients Flavonoidsmentioning
confidence: 99%
“…Apigenin, 4′, 5, 7-trihydroxyflavone, is abundant in vegetables and certain foods that have been used as medicinal plants worldwide for centuries ( Salehi et al, 2019 ; Su et al, 2020 ; Xu et al, 2021 ). Genistein, 4′, 5, 7-trihydroxyisoflavone, was first reported in 1899, and its structure was identified in 1926 ( Jung et al, 2020 ). Apigenin and genistein both target dozens of pharmacological targets, such as estrogen receptors, ABC transporters, membrane proteins, mitochondria-associated proteins, cell cycle-associated proteins, epigenetic regulators, cytokines, and many signaling pathways including NF-κB, MAPK/ERK, JAK/STAT, PI3K/Akt and Wnt/β-catenin pathways, exhibiting therapeutic applications in cardiovascular diseases, neurodegenerative diseases, cancers, etc.…”
Section: Introductionmentioning
confidence: 99%