A brief bout of exercise alters gene expression and distinct gene pathways in peripheral blood mononuclear cells of early- and late-pubertal females

Radom‐Aizik, Shlomit; Zaldivar, Frank; Leu, Szu-Yun; Cooper, Dan M.

doi:10.1152/japplphysiol.00121.2009

Cited by 53 publications

(63 citation statements)

References 30 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several genes in the “cytokine receptor functional group” have been shown to change with exercise. 19,20 Dramatic changes in leukocyte gene expression and alterations in extracellular cytokine concentrations that we observed in this study (namely increases in TGFβ1, P-selectin, IL-6, and TNF-α) suggest that leukocytes are reactive to the stress of exercise and that these alterations may contribute to exercise-induced allergy and asthma. 21,22 …”

Section: Discussionmentioning

confidence: 67%

The Pro- and Anti-Inflammatory Cytokine Response to Exercise in Adolescent Swimmers

Wilson

Zaldivar

Schwindt

2009

Pediatric Asthma, Allergy & Immunology

Self Cite

View full text Add to dashboard Cite

Objective Whether or not individuals with allergy and asthma experience different patterns of change in the balance of both pro- and anti-inflammatory mediators with acute exercise is not known. We hypothesized that adolescent swimmers with a clinical diagnosis of respiratory allergy would have an exaggerated proinflammatory response to laboratory exercise relative to a no-allergy comparison group. Methods Adolescent swimmers (17 with clinical symptoms of respiratory allergy (CSRA) and 17 in comparison group) completed the American Thoracic Society (ATS) exercise challenge on cycle ergometer. Blood was collected at baseline and immediately post-exercise. All study tests were conducted at the Institute for Clinical Translational Science at the University of California, Irvine. Circulating cytokines, growth factors, and adhesion molecules were measured using ELISAs including transforming growth factor-β1 (TGF-β1), tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4), IL-6, IL-10, P-selectin, and immunoglobulin E (IgE). Results There was a trend toward higher resting levels of TNF-α in the CSRA group (P = 0.076). Exercise induced a significant increase in P-selectin and TGF-β1 in both groups. TNF-α increased significantly (17%) in the comparison group (pre = 0.6, post = 0.7 pg/mL), but not in the CSRA group. IL-6 increased significantly in the CSRA group (pre = 0.7, post = 0.8 pg/mL), but not in the comparison group. Circulating levels of IL-4 and IL-10 were not altered immediately post-exercise in either group. Conclusions A short bout of intense exercise increased inflammatory growth factors and adhesion molecules, namely TGF-β1 and P-selectin, both of which are known to be involved in allergic airway diseases. Differences in resting IL-6 and TNF-α and exercise alterations in these cytokines may also contribute to allergic disease in adolescent elite swimmers.

show abstract

Section: Discussionmentioning

confidence: 67%

The Pro- and Anti-Inflammatory Cytokine Response to Exercise in Adolescent Swimmers

Wilson

Zaldivar

Schwindt

2009

Pediatric Asthma, Allergy & Immunology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Up-regulated genes were noted in several categories including immune, inXammatory (more pro-inXammatory than anti-inXammatory) and stress (heat shock proteins and hypoxia-inducible factor-1, HIF). A more recent paper (Radom-Aizik et al 2009) used 20 young female participants, and found altered expression of 622 genes in 11 diVerent gene pathways. SigniWcant gene pathway changes were related to inXammation, stress (heat shock protein-70) and apoptosis (fas ligand) pathways.…”

Section: Discussionmentioning

confidence: 99%

Lower white blood cell counts in elite athletes training for highly aerobic sports

et al. 2010

View full text Add to dashboard Cite

White cell counts at rest might be lower in athletes participating in selected endurance-type sports. Here, we analysed blood tests of elite athletes collected over a 10-year period. Reference ranges were established for 14 female and 14 male sports involving 3,679 samples from 937 females and 4,654 samples from 1,310 males. Total white blood cell counts and counts of neutrophils, lymphocytes and monocytes were quantified. Each sport was scaled (1-5) for its perceived metabolic stress (aerobic-anaerobic) and mechanical stress (concentric-eccentric) by 13 sports physiologists. Substantially lower total white cell and neutrophil counts were observed in aerobic sports of cycling and triathlon (~16% of test results below the normal reference range) compared with team or skill-based sports such as water polo, cricket and volleyball. Mechanical stress of sports had less effect on the distribution of cell counts. The lower white cell counts in athletes in aerobic sports probably represent an adaptive response, not underlying pathology.

show abstract

“…Only a few studies have evaluated whether such an association exists among women with a BRCA1 mutation (10)(11)(12)(13). Cancer-protective mechanisms of physical activity have mainly focused on alterations in levels of sex hormones, inflammatory markers, and growth factors (14)(15)(16). It is plausible that such changes are due to physical activity-induced transcriptional changes, as physical activity has been shown to induce widespread transcriptional effects (17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

Uninterrupted Sedentary Behavior Downregulates BRCA1 Gene Expression

Pettapiece-Phillips

Kotlyar

Chehade

et al. 2016

Cancer Prevention Research

View full text Add to dashboard Cite

BRCA1 mutation carriers face a high lifetime risk of developing breast cancer. Physical activity induces broad transcriptional changes, and multiple studies have documented its beneficial effects across cancers. Because haploinsufficiency predisposes to breast cancer in these women, factors that increase BRCA1 levels may mitigate the effect of the mutation. Whether physical activity modulates BRCA1 expression and whether lifestyle factors could benefit women with a mutation remain unclear. The objective of this study was to systematically evaluate whether physical activity or sedentary behavior affects BRCA1 mRNA expression. Activity levels were assessed in 50 female participants (14 BRCA1 mutation carriers and 36 noncarriers) using the GT3X Actigraph accelerometer, and BRCA1 mRNA expression was quantified from peripheral blood lymphocytes using the Nanostring nCounter Analysis System. There was a significant negative correlation between the longest sedentary bout and BRCA1 mRNA expression (r ¼ -0.32; P ¼ 0.02). Women below the median for the longest sedentary bout had significantly higher BRCA1 mRNA levels compared with women above the median (161 vs. 132 counts; P ¼ 0.04; one-sided Mann-Whitney U test). There was no significant relationship between mean metabolic equivalents of task rate or mean sedentary time and BRCA1 mRNA expression (Spearman correlation P ! 0.75; P ! 0.14; Mann-Whitney U test). These findings suggest that prolonged periods of sedentary behavior are associated with significantly lower BRCA1 mRNA expression. Whether this translates into a potentially more harmful effect in BRCA1 mutation carriers warrants further investigation. Cancer Prev Res; 9(1); 83-88. Ó2015 AACR.

show abstract

A brief bout of exercise alters gene expression and distinct gene pathways in peripheral blood mononuclear cells of early- and late-pubertal females

Abstract: Radom-Aizik S, Zaldivar F Jr, Leu S, Cooper DM. A brief bout of exercise alters gene expression and distinct gene pathways in peripheral blood mononuclear cells of early-and late-pubertal females.

Cited by 53 publications

References 30 publications

The Pro- and Anti-Inflammatory Cytokine Response to Exercise in Adolescent Swimmers

The Pro- and Anti-Inflammatory Cytokine Response to Exercise in Adolescent Swimmers

Lower white blood cell counts in elite athletes training for highly aerobic sports

Uninterrupted Sedentary Behavior Downregulates BRCA1 Gene Expression

Contact Info

Product

Resources

About