A Brief Analysis of Proteomic Profile Changes during Zebrafish Regeneration

Abstract

Unlike mammals, zebrafish are capable to regenerate many of their organs, however, the response of tissue damage varies across tissues. Understanding the molecular mechanism behind the robust regenerative capacity in a model organism may help to identify and develop novel treatment strategies for mammals (including humans). Hence, we systematically analyzed the current literature on the proteome profile collected from different regenerated zebrafish tissues. Our analyses underlining that several proteins and protein families responsible as a component of cytoskeleton and structure, protein synthesis and degradation, cell cycle control, and energy metabolism were frequently identified. Moreover, target proteins responsible for the initiation of the regeneration process, such as inflammation and immune response were less frequently detected. This highlights the limitation of previous proteomic analysis and suggested a more sensitive modern proteomics analysis is needed to unfold the mechanism. This brief report provides a list of target proteins with predicted functions that could be useful for further biological studies.

A systematic proteomic profiling and pathway analysis of protein biomarkers in diabetic retinopathy with subsequent validation of the IL-6 upstream regulator

“…Differentially expressed proteins reported in each study were included in the joint dataset with the following criteria: (1) Proteomic studies of adult patients with DR or DME; (2) proteins were only counted once for each study with multiple spot identifications or evaluated in a different proteomic technology; (3) proteins were included if the expression levels were changed at least 50% compared to control levels [17]. Data sets of proteins were excluded if proteomic results reported in the study exhibited fold changes between 0.8 and 1.2 unless the p-value was significant.…”