A Breathlessness Catastrophizing Scale for chronic obstructive pulmonary disease

Solomon, Brahm K.; Wilson, Keith G.; Henderson, Peter; Poulin, Patricia A.; Kowal, John; McKim, Douglas

doi:10.1016/j.jpsychores.2014.11.020

Cited by 31 publications

(38 citation statements)

References 58 publications

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“…In addition, the average dyspnea catastrophizing levels were rather modest, with individual scores ranging between 0 and maximally 42, which might not fully reflect dyspnea catastrophizing levels of dyspneic patients. For example, mean BCS scores of 18.1 (SD 5 11.7) and 13.3 (SD 5 11.5) were recently reported for patients with COPD at start and end, respectively, of a pulmonary rehabilitation program (Solomon et al, 2015). Therefore, future research is needed that also includes participants with higher levels of dyspnea catastrophizing, for example, from the upper tertile of BCS scores in population-based samples.…”

Section: Discussionmentioning

confidence: 99%

“…These dyspneaspecific forms of negative affectivity have been shown to contribute to several clinical outcomes even after controlling for unspecific general anxiety levels and presumably provide a more specific target for individualized therapeutic interventions (Hayen et al, 2013;von Leupoldt & Janssens, 2016). For example, it has been demonstrated that dyspnea catastrophizing (i.e., an exaggerated negative orientation toward noxious stimuli characterized by rumination, magnification of their threat value, and perceived inability to control) is related to higher dyspnea, psychological distress, and performance in the stair test after rehabilitation (Livermore et al, 2015;Livermore, Sharpe, & McKenzie, 2012;Solomon et al, 2015;Sutton et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

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Dyspnea catastrophizing and neural activations during the anticipation and perception of dyspnea

et al. 2017

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Dyspnea is an aversive symptom in various diseases. High levels of negative affectivity are typically associated with increased dyspnea and changes in its neural processing. Recently, more dyspnea-specific forms of negative affectivity such as dyspnea catastrophizing were suggested to contribute to increased perception of dyspnea beyond effects of rather unspecific negative affectivity such as general anxiety levels. The involved neural mechanisms have not yet been explored. Therefore, the present retrospective analysis examined the associations of dyspnea catastrophizing with neural activations during the anticipation and perception of dyspnea. Sixty-six healthy volunteers underwent 20 blocks of inspiratory resistive load breathing with parallel acquisition of fMRI data. Loads inducing either severe or mild dyspnea (dyspnea conditions) were presented in alternating order, with each condition being visually cued (anticipation conditions). Dyspnea catastrophizing and general trait anxiety were measured with the Breathlessness Catastrophizing Scale (BCS) and the State-Trait Anxiety Inventory, respectively. Correlating the BCS scores with neural activations during the perception of dyspnea yielded no significant results. However, during the anticipation of dyspnea, BCS scores correlated positively with activations of the anterior cingulate cortex (ACC), even after controlling for general anxiety levels. These activations in the ACC were not related to concurrent respiratory parameters. Results suggest that dyspnea catastrophizing in healthy volunteers is associated with stronger ACC recruitment during dyspnea anticipation. Given the established role of the ACC in processing affective states, affect regulation, and antinociception, this might reflect increased affective and/or top-down modulatory processing in individuals with higher dyspnea catastrophizing when anticipating dyspnea.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dyspnea catastrophizing and neural activations during the anticipation and perception of dyspnea

et al. 2017

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“…Indeed, the relation of catastrophizing to fatigue has not been investigated before in patients with ILD. Catastrophizing may contribute to increased intensity of symptom experience [35] and, in chronic pain, catastrophizing is a prospective marker for the risk of severe disability [61]. Catastrophizing can influence the experience of fatigue and seems to be a good predictor of fatigue severity [62].…”

Section: Factors Associated With Fatigue In Patients With Ipf or Sarcmentioning

confidence: 99%

Severe Fatigue is Highly Prevalent in Patients with IPF or Sarcoidosis

Bloem

Mostard

Stoot

et al. 2020

JCM

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In patients with interstitial lung disease (ILD) next to dyspnea, fatigue is expected to be the most prevalent symptom. Surprisingly, the prevalence of severe fatigue has been scarcely studied in ILD patients and limited information on its associated factors is available. This study aimed to determine the prevalence of severe fatigue in patients with idiopathic pulmonary fibrosis (IPF) or pulmonary sarcoidosis and to identify the relationship between fatigue, patient characteristics, and clinical parameters. In this cross-sectional study, fatigue (checklist individual strength-fatigue (CIS-Fat)), demographics, lung function, dyspnea (modified-Medical Research Council (mMRC)), sleepiness (Epworth Sleepiness Scale), anxiety/depression (hospital anxiety and depression scale (HADS-A/HADS-D)), catastrophizing (fatigue catastrophizing scale (FCS)), functional activity impairment (respiratory illness quality-of-life (QoL-RIQ-Activity)), and health status (EuroQol five-dimensional descriptive system (EQ-5D-5L)) were assessed in outpatients with ILD. Mean CIS-Fat scores were 34.1 (SD ± 11.2) in 59 IPF patients and 40.0 (12.3) in 58 sarcoidosis patients. Severe fatigue (SD ± ≥36 points) was present in IPF patients (47.5%) and sarcoidosis (69%). In IPF, CIS-Fat correlated strongly (ρ > 0.5; p < 0.01) with FCS, QoL-RIQ-Activity, and EQ-5D-5L-Health and moderately (0.3 < ρ < 0.5; p < 0.01) with EQ-5D-5L-Index, mMRC, and HADS-D. In sarcoidosis, CIS-Fat correlated strongly with EQ-5D-5L-Health, QoL-RIQ-Activity, EQ-5D-5L-Index, HADS-D, and mMRC and moderately with FCS and hospitalization <12 months. Severe fatigue is highly prevalent in ILD patients and is associated with dyspnea, depression, catastrophizing, functional activity impairments, and QoL.

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“…The Catastrophic Thinking Scale in Asthma (21) and Pain Awareness and Vigilance Scale (22), were modified for breathlessness (see (41)), as no suitable breathlessness-specific questionnaires were available at the time of study. A later study has validated the Catastrophic Thinking Scale for COPD (42), and the resulting questionnaire is very similar, although not identical, to our questionnaire.…”

mentioning

confidence: 68%

Treating the lungs via the brain: Mechanisms underpinning improvements in breathlessness with pulmonary rehabilitation

Herigstad

Faull

Hayen

et al. 2017

Preprint

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BackgroundBreathlessness in chronic obstructive pulmonary disease (COPD) is often discordant with airway pathophysiology (“over-perception”). Pulmonary rehabilitation has profound effects upon breathlessness, without influencing lung function. Learned associations can influence brain mechanisms of sensory perception. We therefore hypothesised that improvements in breathlessness with pulmonary rehabilitation may be explained by changing neural representations of learned associations, reducing “over-perception”.MethodsIn 31 patients with COPD, we tested how pulmonary rehabilitation altered the relationship between brain activity during learned associations with a word-cue task (using functional magnetic resonance imaging), clinical, and psychological measures of breathlessness.ResultsImprovements in breathlessness and breathlessness-anxiety correlated with reductions in word-cue related activity in the insula and anterior cingulate cortex (ACC) (breathlessness), and increased activations in attention regulation and motor networks (breathlessness-anxiety). Greater baseline (pre-rehabilitation) activity in the insula, ACC and prefrontal cortex correlated with the magnitude of improvement in breathlessness and breathlessness anxiety.ConclusionsPulmonary rehabilitation reduces the influence of learned associations upon neural processes that generate breathlessness. Patients with stronger word-cue related activity at baseline benefitted more from pulmonary rehabilitation. These findings highlight the importance of targeting learned associations within treatments for COPD, demonstrating how neuroimaging may contribute to patient stratification and more successful personalised therapy.

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A Breathlessness Catastrophizing Scale for chronic obstructive pulmonary disease

Cited by 31 publications

References 58 publications

Dyspnea catastrophizing and neural activations during the anticipation and perception of dyspnea

Dyspnea catastrophizing and neural activations during the anticipation and perception of dyspnea

Severe Fatigue is Highly Prevalent in Patients with IPF or Sarcoidosis

Treating the lungs via the brain: Mechanisms underpinning improvements in breathlessness with pulmonary rehabilitation

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