A Brazilian species of Entamoeba dispar (ADO) produces amoebic liver abscess in hamsters

Shibayama, Mineko; Dolabella, Silvio Santana; Silva, Edward F.; Tsutsumi, Vı́ctor

doi:10.1016/s1665-2681(19)31943-x

Cited by 17 publications

(13 citation statements)

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“…In a study conducted by Mojarad et al [27], it was shown that the number of different genotypes of E. dispar isolated from asymptomatic cyst passers was very high. In 28 isolates 12 new genotypes were found, a finding consistent with in E. dipar isolates from asymptomatic cyst passers in Mexico [12].…”

Section: Resultsmentioning

confidence: 99%

“…Under this hypothesis, the population densities of both species (in the intestine or the liver) may depend on their particular degree of virulence. In a study conducted by Costa et al [17], it was mention that two isolates of the species E. dispar obtained from Brazilian patients can induce amebic liver abscesses in experimental animals [17,27]. Their results showed that both of the tested isolates (ICB-ADO and MGL) can produce similar cytopathic effects and amebic liver abscesses compared to those produced by a highly virulent E. histolytica EGG strain [17].…”

Section: Resultsmentioning

confidence: 99%

“…Recent studies have demonstrated that isolates of E. dispar and E. histolytica in xenic or monoxenic culture conditions can increase their virulence, causing larger liver abscesses in laboratory animals in comparison to E. histolytica maintained in axenic culture conditions [17,27]. …”

Section: Resultsmentioning

confidence: 99%

“…With this in mind, it is highly possible that interactions of Entamoeba species with both bacteria of intestinal flora [17,27–29] and/or pathogenic bacteria, may modify the infectious behavior of both ( i.e. , the parasite and the enterobacteria).…”

Section: Resultsmentioning

confidence: 99%

“…In addition, the assays utilizing another Brazilian isolate from an asymptomatic patient (MGL) maintained under xenic conditions also induced amebic liver abscesses. This strain was characterized as E. dispar zymodem 1 [17,27]. Moreover, in the presence of Crithidia fasciculate , both the ICB-ADO and MGL strains failed to produce amebic liver abscesses under monoxenic conditions in the hamster model [17,27].…”

Section: Resultsmentioning

confidence: 99%

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Human Amebiasis: Breaking the Paradigm?

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For over 30 years it has been established that the Entamoeba histolytica protozoan included two biologically and genetically different species, one with a pathogenic phenotype called E. histolytica and the other with a non-pathogenic phenotype called Entamoeba dispar. Both of these amoebae species can infect humans. E. histolytica has been considered as a potential pathogen that can cause serious damage to the large intestine (colitis, dysentery) and other extraintestinal organs, mainly the liver (amebic liver abscess), whereas E. dispar is a species that interacts with humans in a commensal relationship, causing no symptoms or any tissue damage. This paradigm, however, should be reconsidered or re-evaluated. In the present work, we report the detection and genotyping of E. dispar sequences of DNA obtained from patients with amebic liver abscesses, including the genotyping of an isolate obtained from a Brazilian patient with a clinical diagnosis of intestinal amebiasis that was previously characterized as an E. dispar species. The genetic diversity and phylogenetic analysis performed by our group has shown the existence of several different genotypes of E. dispar that can be associated to, or be potentiality responsible for intestinal or liver tissue damage, similar to that observed with E. histolytica.

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Section: Resultsmentioning

confidence: 99%