A Brain-specific Grb2-associated Regulator of Extracellular Signal-regulated Kinase (Erk)/Mitogen-activated Protein Kinase (MAPK) (GAREM) Subtype, GAREM2, Contributes to Neurite Outgrowth of Neuroblastoma Cells by Regulating Erk Signaling

Taniguchi, Tomonori; Tanaka, Shigeru; Ishii, Ayumi; Watanabe, Miyuki; Fujitani, Noriko; Sugeo, Ayusa; Gotoh, Shuhei; Ohta, Takeshi; Hiyoshi, Mineyoshi; Matsuzaki, Hitomi; Sakai, Norio; Konishi, Hiroaki

doi:10.1074/jbc.m113.492520

Cited by 28 publications

(30 citation statements)

References 40 publications

(48 reference statements)

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“…anguillicaudatus . The garem and emp2 , which positively regulate and promote cell proliferation and division 27 , 28 , were positively selected in the M . anguillicaudatus clade, and the similar results were also observed in the previous study 12 , suggesting cell proliferation also act as a critical factor in the environmental adaptation in M .…”

Section: Discussionmentioning

confidence: 99%

Full-length transcriptome of Misgurnus anguillicaudatus provides insights into evolution of genus Misgurnus

Zhou

et al. 2018

Sci Rep

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Reconstruction and annotation of transcripts, particularly for a species without reference genome, plays a critical role in gene discovery, investigation of genomic signatures, and genome annotation in the pre-genomic era. This study generated 33,330 full-length transcripts of diploid M. anguillicaudatus using PacBio SMRT Sequencing. A total of 6,918 gene families were identified with two or more isoforms, and 26,683 complete ORFs with an average length of 1,497 bp were detected. Totally, 1,208 high-confidence lncRNAs were identified, and most of these appeared to be precursor transcripts of miRNAs or snoRNAs. Phylogenetic tree of the Misgurnus species was inferred based on the 1,905 single copy orthologous genes. The tetraploid and diploid M. anguillicaudatus grouped into a clade, and M. bipartitus showed a closer relationship with the M. anguillicaudatus. The overall evolutionary rates of tetraploid M. anguillicaudatus were significantly higher than those of other Misgurnus species. Meanwhile, 28 positively selected genes were identified in M. anguillicaudatus clade. These positively selected genes may play critical roles in the adaptation to various habitat environments for M. anguillicaudatus. This study could facilitate further exploration of the genomic signatures of M. anguillicaudatus and provide potential insights into unveiling the evolutionary history of tetraploid loach.

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Section: Discussionmentioning

confidence: 99%

Full-length transcriptome of Misgurnus anguillicaudatus provides insights into evolution of genus Misgurnus

Zhou

et al. 2018

Sci Rep

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“…THEMIS and THEMIS2 are present in all mammals, whereas THEMIS3 is absent in primates. Two single CABIT module proteins are also expressed in mammals; GAREM1 which is broadly expressed [31] and GAREM2 which is expressed in neuronal cells [32]. GAREM1, GAREM2 and most other single CABIT module proteins also contain a Sterile alpha motif (SAM) putative protein interaction domain (Fig.…”

Section: The Themis Enigmamentioning

confidence: 99%

“…THEMIS and THEMIS2 are functionally interchangeable since transgenic expression of THEMIS2 rescued the developmental defect in Themis −/− mice [8]. The single CABIT module mammalian proteins GAREM1 (GRB2-associated and regulator of MAPK1, subtype 1) and GAREM2, are positive regulators of ERK signaling in response to epidermal growth factor (EGF) receptor engagement [31, 32]. Nevertheless, it was reported that ERK activation, calcium flux, NFATC2 nuclear translocation and other effector responses [15] are enhanced in Themis −/− thymocytes under sub-maximal TCR/co-receptor stimulation conditions [14, 15].…”

Section: Reconciling the Models: The Tcr Signaling Conundrummentioning

confidence: 99%

THEMIS: Two Models, Different Thresholds

Choi

Cornall

Lesourne

et al. 2017

Trends in Immunology

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THEMIS, a recently identified T-lineage restricted protein, is the founding member of a large metazoan protein family. Gene inactivation studies have revealed a critical requirement for THEMIS during thymocyte positive selection, implicating THEMIS in signaling downstream of the T cell antigen receptor (TCR); but the mechanistic underpinnings of THEMIS’ function have remained elusive. A previous model posited that THEMIS prevents thymocytes from inappropriately crossing the positive/negative selection threshold by dampening TCR signaling. However, new data suggest an alternative model where THEMIS enhances TCR signaling, enabling thymocytes to reach the threshold for positive selection avoiding death by neglect. We review the data supporting each model and conclude that the preponderance of evidence favors an enhancing function for THEMIS in TCR signaling.

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“…SORBS2 is involved in several biological pathways (Table 2). Sorbin, the product of SORBS2, is an ArgBP2 protein and SH3 domain-containing protein 2 and might be involved in insulin-mediated translocation of GLUT4 and thereby might affect energy storage [47]. Previous research has highlighted the role of this functional protein in disease states [48][49][50][51].…”

Section: Discussionmentioning

confidence: 99%

The Epigenetic Overlap between Obesity and Mood Disorders: A Systematic Review

Gharipour

Barekatain

Sung

et al. 2020

IJMS

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(1) Background: Obesity and mood disorders are considered as the most prevalent morbidities in many countries. We suppose that epigenetic mechanisms may induce higher rates of obesity in subjects who suffer from mood disorders. In this systematic review, we focused on the potential roles of DNA methylation on mood disorders and obesity development. (2) Methods: This systematic review was conducted in accordance with the PRISMA statement and registered in Prospero. A systematic search was conducted in MEDLINE, Scopus, Web of Science, Cochrane Central database, EMBASE, and CINHAL. We also conducted a Grey literature search, such as Google Scholar. (3) Results: After deduplication, we identified 198 potentially related citations. Finally, ten unique studies met our inclusion criteria. We have found three overlap genes that show significant DNA methylation changes, both in obesity and depression. Pathway analysis interaction for TAPBP, BDNF, and SORBS2 confirmed the relation of these genes in both obesity and mood disorders. (4) Conclusions: While mechanisms linking both obesity and mood disorders to epigenetic response are still unknown, we have already known chronic inflammation induces a novel epigenetic program. As the results of gene enrichment, pathways analysis showed that TAPBP, BDNF, and SORBS2 linked together by inflammatory pathways. Hypermethylation in these genes might play a crucial rule in the co-occurrence of obesity and mood disorders.

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A Brain-specific Grb2-associated Regulator of Extracellular Signal-regulated Kinase (Erk)/Mitogen-activated Protein Kinase (MAPK) (GAREM) Subtype, GAREM2, Contributes to Neurite Outgrowth of Neuroblastoma Cells by Regulating Erk Signaling

Cited by 28 publications

References 40 publications

Full-length transcriptome of Misgurnus anguillicaudatus provides insights into evolution of genus Misgurnus

Full-length transcriptome of Misgurnus anguillicaudatus provides insights into evolution of genus Misgurnus

THEMIS: Two Models, Different Thresholds

The Epigenetic Overlap between Obesity and Mood Disorders: A Systematic Review

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