Abstract:Breeding for high and low hypothermic responses to systemic administration of a serotonin 1A (5-HT 1A ) receptor agonist (8-hydroxy-2-(din-propylamino)tetralin, 8-OH-DPAT) has resulted in high DPATsensitive (HDS) and low DPAT-sensitive (LDS) lines of rats, respectively. These lines also differ in several behavioral measures associated with stress. In the present microdialysis study we observed that basal 5-HT concentrations in the prefrontal cortex and dorsal hippocampus did not differ significantly between HD… Show more
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