A bradykinin potentiating peptide from Egyptian cobra venom strongly affects rat atrium contractile force and cellular calcium regulation

El-Saadani, M. A.; El-Sayed, Muhammad F.

doi:10.1016/j.cca.2003.11.001

Cited by 8 publications

(4 citation statements)

References 24 publications

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“…A possible reason for this is the important role of BPPs in prey immobilization. Hypotension is usually associated with poisoning upon snake envenomation [ 33 , 34 , 35 ]. Natriuretic peptides (NPs), like that described in Table 2 , have profound effects on the cardiovascular system [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Elapid Snake Venom Analyses Show the Specificity of the Peptide Composition at the Level of Genera Naja and Notechis

Munawar

Trusch

Georgieva³

et al. 2014

Toxins

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Elapid snake venom is a highly valuable, but till now mainly unexplored, source of pharmacologically important peptides. We analyzed the peptide fractions with molecular masses up to 10 kDa of two elapid snake venoms—that of the African cobra, N. m. mossambica (genus Naja), and the Peninsula tiger snake, N. scutatus, from Kangaroo Island (genus Notechis). A combination of chromatographic methods was used to isolate the peptides, which were characterized by combining complimentary mass spectrometric techniques. Comparative analysis of the peptide compositions of two venoms showed specificity at the genus level. Three-finger (3-F) cytotoxins, bradykinin-potentiating peptides (BPPs) and a bradykinin inhibitor were isolated from the Naja venom. 3-F neurotoxins, Kunitz/basic pancreatic trypsin inhibitor (BPTI)-type inhibitors and a natriuretic peptide were identified in the N. venom. The inhibiting activity of the peptides was confirmed in vitro with a selected array of proteases. Cytotoxin 1 (P01467) from the Naja venom might be involved in the disturbance of cellular processes by inhibiting the cell 20S-proteasome. A high degree of similarity between BPPs from elapid and viperid snake venoms was observed, suggesting that these molecules play a key role in snake venoms and also indicating that these peptides were recruited into the snake venom prior to the evolutionary divergence of the snakes.

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Section: Discussionmentioning

confidence: 99%

Elapid Snake Venom Analyses Show the Specificity of the Peptide Composition at the Level of Genera Naja and Notechis

Munawar

Trusch

Georgieva³

et al. 2014

Toxins

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“…A bradykinin potentiating peptide composed of 15 amino acids was isolated from the Egyptian cobra N. haje venom [135]. Treatment of rat atrial preparation with isolated peptide caused a significant reduction in myocardial force.…”

Section: Other Non-enzymatic Proteinsmentioning

confidence: 99%

Non-Lethal Polypeptide Components in Cobra Venom

Utkin

Osipov²

2007

CPD

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Snakes from several genera (mostly from Naja genus) belonging to the Elapidae family are usually named cobras. The effect of cobra bites is mainly neurotoxic. This is explained by the presence of highly potent alpha-neurotoxin in their venoms. The other two highly toxic components of cobra venoms are cytotoxins and phospholipases A(2). These three types of toxins constitute a major part of cobra venom. They have attracted the attention of researchers for many years and have been very well studied and thoroughly described. However cobra venoms contain also many other less abundant components which possess very low toxicity or even are not toxic at all. These components, mostly proteins, belong to different structural and functional types, and the reason for their presence in the venom is not always evident. Some of them are known for many years (e.g., nerve growth factor and cobra venom factor); others (e.g., cysteine rich secretory proteins, CRISPs) were discovered only recently. There are non-lethal proteins with unique biological activities that can be used as biochemical tools, while others may be regarded as potential leads for drug design. This review is the first attempt to systemize the available data on non-lethal components of cobra venom.

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“…In addition, BPPs have a direct effect on the components of the cardiovascular system. For example, in some cases there is no correlation between ACE inhibition and the hypotensive effect [ 31 ], and a BPP from the venom of the cobra Naja haje haje dose-dependently reduces the contractility of the rat atria [ 32 ]. The BPP Bj-PRO-5a was also found to cause vasodilation by interacting with the muscarinic cholinergic receptors M1 and bradykinin receptors BK B2 and triggering NO synthesis by the endothelium [ 33 ].…”

Section: Snake Venoms: Composition and Propertiesmentioning

confidence: 99%

Cardiovascular Effects of Snake Toxins: Cardiotoxicity and Cardioprotection

Аверин

Utkin

2021

Acta Naturae

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Snake venoms, as complex mixtures of peptides and proteins, affect various vital systems of the organism. One of the main targets of the toxic components from snake venoms is the cardiovascular system. Venom proteins and peptides can act in different ways, exhibiting either cardiotoxic or cardioprotective effects. The principal classes of these compounds are cobra cardiotoxins, phospholipases A2, and natriuretic, as well as bradykinin-potentiating peptides. There is another group of proteins capable of enhancing angiogenesis, which include, e.g., vascular endothelial growth factors possessing hypotensive and cardioprotective activities. Venom proteins and peptides exhibiting cardiotropic and vasoactive effects are promising candidates for the design of new drugs capable of preventing or constricting the development of pathological processes in cardiovascular diseases, which are currently the leading cause of death worldwide. For example, a bradykinin-potentiating peptide from Bothrops jararaca snake venom was the first snake venom compound used to create the widely used antihypertensive drugs captopril and enalapril. In this paper, we review the current state of research on snake venom components affecting the cardiovascular system and analyse the mechanisms of physiological action of these toxins and the prospects for their medical application.

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A bradykinin potentiating peptide from Egyptian cobra venom strongly affects rat atrium contractile force and cellular calcium regulation

Cited by 8 publications

References 24 publications

Elapid Snake Venom Analyses Show the Specificity of the Peptide Composition at the Level of Genera Naja and Notechis

Elapid Snake Venom Analyses Show the Specificity of the Peptide Composition at the Level of Genera Naja and Notechis

Non-Lethal Polypeptide Components in Cobra Venom

Cardiovascular Effects of Snake Toxins: Cardiotoxicity and Cardioprotection

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