A Bottom-Up Approach for Developing Aptasensors for Abused Drugs: Biosensors in Forensics

Aydındogan, Eda; Balaban, Simge; Evran, Serap; Çoşkunol, Hakan

doi:10.3390/bios9040118

Cited by 19 publications

(10 citation statements)

References 199 publications

(312 reference statements)

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“…Besides drug screening, aptasensors are widely used in forensic analysis, food safety, environmental monitoring, and biomedical diagnosis [116]. New research efforts are being used to fabricate aptasensors that are affordable, facile, and portable with excellent stability for illicit drug detection [117]. Different signals result from the interaction of an aptamer with the illicit drug which includes electrochemical [118], fluorescence [119], SER scattering [98], and colorimetric [120], etc.…”

Section: Aptasensorsmentioning

confidence: 99%

The Application of Nanosensors in Illicit Drugs Determination: A Review

Shuaibu

Audu

Igenepo

2021

CJAST

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The utilization of nanomaterials (NMs) to produce nanosensors for detecting drugs in a wide range of materials has attracted global attention. Various categories of NMs have been synthesized and applied for the qualitative determination of some additives, contaminants, and illicit materials owing to their unique physicochemical properties at the nanoscale to impact desired effects. Rapid and facile detection techniques employed for on-site analysis of illicit drugs using NMs are reviewed. It is noted that NMs are good candidates in the fabrication of nanosensors for the sensitive detections and determinations of illicit drugs. Thus, this review is focused on the application of these sensors for illicit drug detection. Hence, the application of plasmonic/optical properties of NMs to enhance illicit drug detection in biological samples has been discussed. The fabricated sensors have been shown to possess enhanced selectivity, sensitivity, cost-effectiveness as well as improved automation. As highlighted in the in-depth review, the sensors are designed to utilize biological receptors with a transducer component to detect the analyte-biorecognition element interaction which resulted in producing an optimum signal.

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Section: Aptasensorsmentioning

confidence: 99%

The Application of Nanosensors in Illicit Drugs Determination: A Review

Shuaibu

Audu

Igenepo

2021

CJAST

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“…Biosensors allow quantitative analysis of chemical species such as abused drugs in biological samples including blood, salvia, sweat, and urine. [18,19] At present, various types of biosensor technologies (e.g., electrochemical, optical, piezoelectric, magnetic, and thermometric) are being investigated for drug detection. [20][21][22] In addition, hybrid technologies (e.g., electrochemical/optical) have been developed recently to address the drawbacks of electrochemical biosensing of chemical compounds.…”

Section: Introductionmentioning

confidence: 99%

Nanoarchitectonics for Abused‐Drug Biosensors

Moradi

Khalili

Septiani

et al. 2021

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analogs). Illicit drugs cause damaging lifetime alterations in the brain, making it very difficult to overcome the addiction without specialized, medical assistance. Drug addiction is a long-lasting, reverting psychiatric disorder and is a major public health issue affecting many elements in society such as health care, productivity, policing, crimes, and accidents. According to 2008 estimations, roughly, 4 million people are using opium globally and 80% of them are living in Asia. Studies have shown a link between opium use and diverse adverse health effects such as different types of cancers including oral, bladder, lung, and gastric cancers. [5][6][7] Opioid derivatives, morphine, codeine, fentanyl, or buprenorphine are effective analgesics for post-operative and cancer pain relief but several studies have highlighted the link between their long-term administration and high abuse potential. [8] Morphine is the most potent analgesic for chronic pain; however, its clinical use is restricted since the opiate naturally brings about tolerance and has severe withdrawal symptoms with a high risk of relapse. Over-the-counter Rapid, accessible, and highly accurate biosensors for the detection of addictive and abused drugs are needed to reduce the adverse personal and societal impacts of addiction. Modern sensors that utilize next-generation technologies, e.g., nanobiotechnology and nanoarchitectonics, have triggered revolutionary progress in the field as they allow accurate detection and tracking of trace levels of major classes of drugs. This paper reviews advances in the field of biosensors for the detection of commonly abused drugs, both prescribed such as codeine and morphine, and illegal narcotics like cocaine.

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“…Several excellent reviews have been published to give a broad insight into conventional and emerging techniques for the detection of illegal drugs and their metabolites. Reviews or other papers covering the detection of drugs, e.g., via the testing of hair [ 6 , 7 , 8 , 9 ], the use of molecularly imprinted polymers [ 10 , 11 ], aptamers [ 12 ], ion mobility spectrometry [ 10 , 11 ], mass spectrometry [ 13 , 14 , 15 , 16 , 17 ], hybrid methods [ 18 ], electrochemical methods [ 19 , 20 ], biosensors [ 12 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ], and immunoassays [ 35 , 36 , 37 ] have been published. Quite popular in analytical chemistry was the detection of cocaine on banknotes [ 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ].…”

Section: Introductionmentioning

confidence: 99%

Cocaine Detection by a Laser-Induced Immunofluorometric Biosensor

et al. 2021

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The trafficking of illegal drugs by criminal networks at borders, harbors, or airports is an increasing issue for public health as these routes ensure the main supply of illegal drugs. The prevention of drug smuggling, including the installation of scanners and other analytical devices to detect small traces of drugs within a reasonable time frame, remains a challenge. The presented immunosensor is based on a monolithic affinity column with a large excess of immobilized hapten, which traps fluorescently labeled antibodies as long as the analyte cocaine is absent. In the presence of the drug, some binding sites of the antibody will be blocked, which leads to an immediate breakthrough of the labeled protein, detectable by highly sensitive laser-induced fluorescence with the help of a Peltier-cooled complementary metal-oxide-semiconductor (CMOS) camera. Liquid handling is performed with high-precision syringe pumps and microfluidic chip-based mixing devices and flow cells. The biosensor achieved limits of detection of 7 ppt (23 pM) of cocaine with a response time of 90 s and a total assay time below 3 min. With surface wipe sampling, the biosensor was able to detect 300 pg of cocaine. This immunosensor belongs to the most sensitive and fastest detectors for cocaine and offers near-continuous analyte measurement.

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A Bottom-Up Approach for Developing Aptasensors for Abused Drugs: Biosensors in Forensics

Cited by 19 publications

References 199 publications

The Application of Nanosensors in Illicit Drugs Determination: A Review

The Application of Nanosensors in Illicit Drugs Determination: A Review

Nanoarchitectonics for Abused‐Drug Biosensors

Cocaine Detection by a Laser-Induced Immunofluorometric Biosensor

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