A Boron-10 nitride nanosheet for combinational boron neutron capture therapy and chemotherapy of tumor

Li, Liping; Keino, Dai; Li, Jiyuan; Shi, Yaxin; Zhang, Zizhu; Liu, Tong; Xie, Jun; Zhang, Ruiping; Liu, Zhibo

doi:10.1016/j.biomaterials.2020.120587

Cited by 31 publications

(20 citation statements)

References 31 publications

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“…Effective anti-tumor neutron irradiation of 10B in 10BN is possible due to the high-water dispensability. 10BN can be used promisingly as a delivery agent for the medication of the doomed cell in BNCT [38]. The boron nitride nanotubes in which DSPE-PEG2000 are used to prepare BNNT's in a suspended aqueous solution.…”

Section: 51mentioning

confidence: 99%

A Mini Review on Application of Boron Neutron Capture Therapy in Cancer Treatment

Namdev

Kaur

2022

IOP Conf. Ser.: Mater. Sci. Eng.

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Nowadays, Cancer is undoubtedly a consequential and potentially life-threatening illness. In the U.S., Around 1.7 million people discerned with Cancer last year. The application of boron in cancer treatment is applicable as therapy known as Boron Neutron Capture Therapy (BNCT). It is an analeptic technique that depends on the nuclear capture and fission reaction that results in various particles such as Li, He nuclei with their kinetic energy and γ-radiation. These radiations kill the malignant cells in our body without damaging the normal tissue. Boron particles delivered selectively to only malignant cells by minimizing their concentration in normal cells. In this article, The clinical trials, clinical investigation in Different countries with a different type of Cancer as Lung, Brain, Head/Neck, Hepatic and gastrointestinal. Various delivery methods of Boron agents in the tumor cells recently developed boron delivery agents, and different techniques of their dose distribution explain. In recent years, boron compounds were applied with porphyrin, copolymers, nanoparticles, other peptides, EGRF’s, and Liposomes to intensify their killer properties toward target cancer cells. BNCT is also effectively used for the medication of various kinds of Cancers explained. The purpose of this article is to indicate the intelligible way of BNCT(Reactor-Based) for the treatment of malignant cells.

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Section: 51mentioning

confidence: 99%

A Mini Review on Application of Boron Neutron Capture Therapy in Cancer Treatment

Namdev

Kaur

2022

IOP Conf. Ser.: Mater. Sci. Eng.

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“…Combined therapy provides new opportunities for effective cancer treatment by utilizing the complementary advantages of different therapeutic methods [ 7 , 8 ]. For instance, radiotherapy (RT), one of the most effective treatment strategies, has been extensively used in clinical cancer treatment [ 9 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

Semiconducting polymer nano-radiopharmaceutical for combined radio-photothermal therapy of pancreatic tumor

Shi

Zhang

et al. 2021

J Nanobiotechnol

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Background Pancreatic ductal adenocarcinoma (PDAC) is a devastatingly malignant tumor with a high mortality. However, current strategies to treat PDAC generally have low efficacy and high side-effects, therefore, effective treatment against PDAC remains an urgent need. Results We report a semiconducting polymer nano-radiopharmaceutical with intrinsic photothermal capability and labeling with therapeutic radioisotope 177Lu (177Lu-SPN-GIP) for combined radio- and photothermal therapy of pancreatic tumor. 177Lu-SPN-GIP endowed good stability at physiological conditions, high cell uptake, and long retention time in tumor site. By virtue of combined radiotherapy (RT) and photothermal therapy (PTT), 177Lu-SPN-GIP exhibited enhanced therapeutic capability to kill cancer cells and xenograft tumor in living mice compared with RT or PTT alone. More importantly, 177Lu-SPN-GIP could suppress the growth of the tumor stem cells and reverse epithelial mesenchymal transition (EMT), which may greatly reduce the occurrence of metastasis. Conclusion Such strategy we developed could improve therapeutic outcomes over traditional RT as it is able to ablate tumor with relatively lower doses of radiopharmaceuticals to reduce its side effects. Graphical abstract

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“…硼中子俘获治疗(boron neutron capture therapy, BNCT)是一种基于含 10 B 硼药和中子照射的二元靶向肿瘤治疗方法. BNCT 治疗肿瘤首先对患者注射硼药，使之聚集于肿瘤部位，然后利用热中子或超热中子束对肿瘤部位进行照射， 10 B 与中子碰撞发生核裂变反应产生具有高传能线密度的 α 粒子和反冲 7 Li 从而选择性地杀死肿瘤细胞 [1,2] . 日本已于 2020 年批准将 BNCT 用于头颈癌的治疗，标志着 BNCT 正式成为临床上治疗肿瘤的手段之一 [3] .…”

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“…在 BNCT 治疗结束后对小鼠注射一定剂量的维生素 C 可使剩余的纳米颗粒快速降解并排出体外，大大提高了纳米硼药的安全性. 此外，纳米 BN 片还可以作为载体装载阿霉素(DOX)，而中子照射大大促进了 DOX 从复合物上释放，实现了肿瘤 BNCT/化疗联合治疗 [7] . 最近，邢更妹课题组报道了一种外泌体修饰的含硼荧光碳点，该纳米硼药具有穿越血脑屏障的功能，单次中子照射就对小鼠脑胶质瘤显示出良好的治疗效果，显著延长了荷瘤小鼠的存活率 [14] .…”

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“…* Corresponding author, E-mail: lizhao@suda.edu.cn Boron neutron capture therapy (BNCT), which is capable of killing cancer cells precisely with α particles and recoiling7 Li nuclei produced by the nuclear fission reaction of thermal neutrons and 10 B in the cells, has attracted tremendous attentions in recent years.https://engine.scichina.com/doi/10.1360/TB-2021-0902…”

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Doxorubicin-conjugated <sup>10</sup>B<sub>4</sub>C nanoparticles: Preparation and application in combined boron neutron capturetherapy/chemotherapy

et al. 2021

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网络版发表放射医学与辐射防护国家重点实验室创新项目(GZC00102)资助摘要硼中子俘获治疗(boron neutron capture therapy, BNCT)是一种二元靶向肿瘤治疗方法，研发新型多功能硼药是提高 BNCT 疗效的关键. 本研究通过对 10 B 4 C 纳米颗粒进行表面化学修饰制备了一种新型多功能纳米硼药. 首先在 10 B 4 C 纳米颗粒表面接枝超支化聚丙三醇(PG)，然后通过 pH 敏感的腙键偶联阿霉素(DOX)，得到纳米硼药 10 B 4 C-PG-DOX. PG 层的高亲水性使 10 B 4 C-PG-DOX 在水溶液中具有良好的分散性和稳定性；而 DOX 单元的引入使 10 B 4 C-PG-DOX 带有正电荷并赋予纳米颗粒一定的亲脂性，从而更容易被肿瘤细胞内吞. 当 10 B 4 C-PG-DOX 的浓度为 10 μg 10 B/mL 时，平均每个 4T1 小鼠乳腺癌细胞中 10 B 原子数高达(4.92 ± 0.36) × 10 11 个. 10 B 4 C-PG-DOX 进入 4T1 细胞后，主要分布在溶酶体中，而溶酶体的酸性环境有利于腙键断裂并释放 DOX，从而对细胞产生化疗效应. 结合加速器热中子照射， 10 B 4 C-PG-DOX 对 4T1 细胞展现出良好的 BNCT/化学联合治疗

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A Boron-10 nitride nanosheet for combinational boron neutron capture therapy and chemotherapy of tumor

Cited by 31 publications

References 31 publications

A Mini Review on Application of Boron Neutron Capture Therapy in Cancer Treatment

A Mini Review on Application of Boron Neutron Capture Therapy in Cancer Treatment

Semiconducting polymer nano-radiopharmaceutical for combined radio-photothermal therapy of pancreatic tumor

Doxorubicin-conjugated <sup>10</sup>B<sub>4</sub>C nanoparticles: Preparation and application in combined boron neutron capturetherapy/chemotherapy

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A Boron-10 nitride nanosheet for combinational boron neutron capture therapy and chemotherapy of tumor

Cited by 31 publications

References 31 publications

A Mini Review on Application of Boron Neutron Capture Therapy in Cancer Treatment

A Mini Review on Application of Boron Neutron Capture Therapy in Cancer Treatment

Semiconducting polymer nano-radiopharmaceutical for combined radio-photothermal therapy of pancreatic tumor

Doxorubicin-conjugated &lt;sup&gt;10&lt;/sup&gt;B&lt;sub&gt;4&lt;/sub&gt;C nanoparticles: Preparation and application in combined boron neutron capturetherapy/chemotherapy

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Doxorubicin-conjugated <sup>10</sup>B<sub>4</sub>C nanoparticles: Preparation and application in combined boron neutron capturetherapy/chemotherapy