A blistering rash and swollen knees

Cytomegalovirus Infection in Normal and Immunocompromised Humans

“…Specific dermatological manifestations have been reported only in 2 cases. They consisted of erythematous, edematous, purpuric papules and plaques over a livedo pattern on the lower extremities of a 7-year-old girl [12]and a purpuric rash with bullae on the legs in an adult woman [29]. The case of a patient with an acute papular and purpuric dermatosis in a characteristic ‘gloves-and-socks’ distribution is also worth mentioning [30].…”

Vesicular and pustular eruption related to cytomegalovirus in an immunocompetent patient

“…CMV‐related cutaneous manifestations in immunocompetent individuals have rarely been reported in the literature 3,4,6 . 7, 11–14 Seishima et al . reported rubella‐like or morbilliform eruptions in nine non‐immunosuppressed patients with positive IgM antibody to CMV 15 .…”

“…Acute papular and purpuric lesions due to CMV infection have been described in a characteristic glove and stocking distribution 17 . In the literature, there have been three cases of leucocytoclastic vasculitis related to CMV occurring in healthy subjects, one in a 7‐year‐old girl, one in a 4‐month‐old baby and one in a 36‐year‐old woman 12–14 …”

“…CMV-related cutaneous manifestations in immunocompetent individuals have rarely been reported in the literature. 3,4,6,7,[11][12][13][14] Seishima et al reported rubellalike or morbilliform eruptions in nine non-immunosuppressed patients with positive IgM antibody to CMV. 15 Recently, evidence of CMV has been observed in patients with erythema multiforme suggesting a possible role of the virus in the pathogenesis of this disease.…”

“…17 In the literature, there have been three cases of leucocytoclastic vasculitis related to CMV occurring in healthy subjects, one in a 7-year-old girl, one in a 4-month-old baby and one in a 36-year-old woman. [12][13][14] Histopathologic features of cutaneous CMV manifestations are well described in immunocomprimised patients and include enlarged irregularly shaped endothelial cells containing intracytoplasmic and intranuclear inclusions. This microscopic finding is the most practical method for diagnosing cytomegalovirus infection and is indicative of direct infection.…”