A Blinded, Randomized, Split-Face Pilot Study of Bruising and Pain With Hyaluronic Acid for Correction of Perioral Lines Using No Lidocaine, Lidocaine Alone, and Lidocaine and Epinephrine

Moradi, Amir; Shirazi, Azadeh; Moradi-Poehler, Jeanette; Turner, Jessica; Howell, David J.

doi:10.1093/asj/sjv043

Cited by 8 publications

(11 citation statements)

References 27 publications

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“…In all but two studies, 31 , 32 the Belotero ® dermal fillers did not contain lidocaine, since the addition of lidocaine to the Belotero ® range is relatively recent (April 2014 for Belotero ® Basic/Balance and Belotero ® Intense, January 2015 for Belotero ® Volume).…”

Section: Resultsmentioning

confidence: 99%

“…Among the 20 studies that investigated the performance and safety of Belotero ® Basic/Balance, six were focused on nasolabial folds (NLFs), 9 , 33 – 37 five on various facial areas, 26 , 27 , 32 , 38 , 39 two on infraorbital hollow, 22 , 40 one on tear trough, 41 one on lip volume restoration, 42 one on perioral lines, 31 and one on atrophic scars. 25 In addition, three studies presented data on Belotero ® Basic/Balance combined to other Belotero ® dermal fillers for deep lines and wrinkles filling, 28 whole-face rejuvenation, 30 or HIV-associated facial lipoatrophy.…”

Section: Resultsmentioning

confidence: 99%

“…The results of the study on atrophic scars 25 are discussed in the “Belotero ® Soft” section. The other studies where Belotero ® Basic/Balance was investigated were focused on the safety of the product, 26 , 38 the reduction of pain by the addition of lidocaine, 31 , 32 or did not formally assess the performance of the filler. 39 , 42…”

Section: Resultsmentioning

confidence: 99%

“… 32 Milder and nonstatistically significant benefits were observed in a parallel-group trial, with mean pain scores (on each side of the face) following injection slightly lower with lidocaine (3.6–3.8 without epinephrine, 3.6–4.6 with epinephrine) than without lidocaine (4.5–5.3). 31 …”

Section: Resultsmentioning

confidence: 99%

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Hyaluronic acid fillers with cohesive polydensified matrix for soft-tissue augmentation and rejuvenation: a literature review

Prasetyo¹,

Prager²,

Rubin

et al. 2016

CCID

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BackgroundCohesive monophasic polydensified fillers show unique viscoelastic properties and variable density of hyaluronic acid, allowing for a homogeneous tissue integration and distribution of the material.ObjectiveThe aim of this paper was to review the clinical data regarding the performance, tolerability, and safety of the Belotero® fillers for soft-tissue augmentation and rejuvenation.MethodsA literature search was performed up until May 31, 2015 to identify all relevant articles on Belotero® fillers (Basic/Balance, Hydro, Soft, Intense, Volume) and equivalent products (Esthélis®, Mesolis®, Fortélis®, Modélis®).ResultsThis comprehensive review included 26 papers. Findings from three randomized controlled trials showed a greater reduction in nasolabial fold severity with Belotero® Basic/Balance than with collagen (at 8, 12, 16, and 24 weeks, n=118) and Restylane® (at 4 weeks, n=40), and higher patient satisfaction with Belotero® Intense than with Perlane® (at 2 weeks, n=20). With Belotero® Basic/Balance, an improvement of at least 1 point on the severity scale can be expected in ~80% of patients 1–6 months after injection, with an effect still visible at 8–12 months. Positive findings were also reported with Belotero® Volume (no reduction in hyaluronic acid volume at 12 months, as demonstrated by magnetic resonance imaging), Soft (improvement in the esthetic outcomes when used in a sequential approach), and Hydro (improvement in skin appearance in all patients). The most common adverse effects were mild-to-moderate erythema, edema, and hematoma, most of which were temporary. There were no reports of Tyndall effect, nodules, granulomas, or tissue necrosis.ConclusionClinical evidence indicates sustainable esthetic effects, good safety profile, and long-term tolerability of the Belotero® fillers, particularly Belotero® Basic/Balance and Intense.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Hyaluronic acid fillers with cohesive polydensified matrix for soft-tissue augmentation and rejuvenation: a literature review

Prasetyo¹,

Prager²,

Rubin

et al. 2016

CCID

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“…Previous studies have not shown an overall benefit of having lidocaine with epinephrine versus lidocaine alone. 15 Injection volumes will vary with the location of the treatment site, the size of the area being treated, and individual patient characteristics. With CaHA it is important not to overcorrect a contour deficiency and a 1:1 correction factor should be used.…”

Section: Jawline Procedural Approachmentioning

confidence: 99%

Nonsurgical Chin and Jawline Augmentation Using Calcium Hydroxylapatite and Hyaluronic Acid Fillers

Moradi¹,

Shirazi²,

Roy

2019

Facial plast Surg

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The shape of the jawline from the mandibular angle to its most forward point at the chin has a profound effect on an individual's appearance and is an area of concern for many seeking esthetic procedures. Dermal filler injections alone or in combination with other modalities, such as skin tightening energy devices, allow enhancement of the jawline while avoiding the need for surgical procedures. The authors introduce new anatomical zones and nomenclature to enhance safety and outcome when enhancing the jawline. Cadaver dissections were performed to better understand landmarks and potential risks and a topographic guide proposed to assist clinicians to create an esthetically pleasing jawline. Techniques for jawline rejuvenation with calcium hydroxylapatite (CaHA) and high G prime hyaluronic acid (HA) fillers are described. When considered as an esthetic unit, the jawline can be broken down into masseteric, buccal, and mental zones, each with their own injection protocols and safety considerations. Dermal fillers suitable for jawline rejuvenation include either CaHA with or without integral lidocaine, a high G prime HA filler, or a hybrid mixture of CaHA and HA, depending on the desired esthetic outcome and the individual's needs. Small volumes of product per injection point achieve the most natural esthetic outcome and minimize serious adverse events. With these techniques, the angle of the mandible is better defined, the pre- and postjowl hollows are filled, and as a result the jawline appears visibly straighter. CaHA and high G prime HA fillers are effective nonsurgical treatments for redefining the mandibular angle and straightening the contour of the jaw. For optimal results, the jawline should be considered as an esthetic unit and careful consideration paid to anatomical landmarks that influence efficacy and safety.

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Does needle size matter? Effects of micro-hypodermic needle injections of botulinum toxin type A in patients with hemifacial spasm

Maytharakcheep,

Phokaewvarangkul,

Bhidayasiri

2024

Parkinsonism & Related Disorders

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A Blinded, Randomized, Split-Face Pilot Study of Bruising and Pain With Hyaluronic Acid for Correction of Perioral Lines Using No Lidocaine, Lidocaine Alone, and Lidocaine and Epinephrine

Abstract: No significant difference was found in bruising or pain in patients treated with BEL, BEL-L, and BEL-LE. Studies with a considerably larger sample size are warranted to determine statistically significant and clinically meaningful differences between and among the various formulations.

Cited by 8 publications

References 27 publications

Hyaluronic acid fillers with cohesive polydensified matrix for soft-tissue augmentation and rejuvenation: a literature review

Hyaluronic acid fillers with cohesive polydensified matrix for soft-tissue augmentation and rejuvenation: a literature review

Nonsurgical Chin and Jawline Augmentation Using Calcium Hydroxylapatite and Hyaluronic Acid Fillers

Does needle size matter? Effects of micro-hypodermic needle injections of botulinum toxin type A in patients with hemifacial spasm

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