A Blinded Evaluation of Brain Morphometry for Differential Diagnosis of Atypical Parkinsonism
Kazuya Kawabata,
Florian Krismer,
Beatrice Heim
et al.
Abstract:BackgroundAdvanced imaging techniques have been studied for differential diagnosis between PD, MSA, and PSP.ObjectivesThis study aims to validate the utility of individual voxel‐based morphometry techniques for atypical parkinsonism in a blinded fashion.MethodsForty‐eight healthy controls (HC) T1‐WI were used to develop a referential dataset and fit a general linear model after segmentation into gray matter (GM) and white matter (WM) compartments. Segmented GM and WM with PD (n = 96), MSA (n = 18), and PSP (n … Show more
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