A bitter herbal medicine Gentiana scabra root extract stimulates glucagon-like peptide-1 secretion and regulates blood glucose in db/db mouse

Suh, Hyo-Weon; Lee, Ki-Beom; Kim, Ki‐Suk; Yang, Hea Jung; Choi, Eun-Kyeong; Shin, Min Hee; Park, Yong Seek; Na, Yun-Cheol; Ahn, Kwang Seok; Jang, Young Pyo; Um, Jae Young; Jang, Hyeung-Jin

doi:10.1016/j.jep.2015.06.042

Cited by 46 publications

(34 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies in mice that are deficient in oral taste processing (P2X2-P2X3 double knock-out) showed that postingestive chemosensory cues (umami) can drive nutrient intake through activation of a more posterior part of the nucleus tractus solitarii than oral cues (Stratford & Finger 2011). Finally, glucose-induced increases in plasma levels of GLP-1 and insulin were increased upon treatment with DB or Gentiana Scabra extract (Kim et al 2014, Suh et al 2015. All together, these results indicate that the enteroendocrine cell is able to sense bitter tastants in an analogue fashion to TRCs on the tongue.…”

Section: Expression and Function Of Extra-oral Bitter Taste Receptorsmentioning

confidence: 72%

“…, Suh et al . ). All together, these results indicate that the enteroendocrine cell is able to sense bitter tastants in an analogue fashion to TRCs on the tongue.…”

Section: Expression and Function Of Extra‐oral Bitter Taste Receptorsmentioning

confidence: 97%

“…The human enteroendocrine cell line HuTu-80 released CCK in response to an extract of the plant Hoodia Gordonii, presumably via activation of hTAS2R14 (Le Neve et al 2010). In another human enteroendocrine cell line, NCI-H716, bitter tastants (oflatoxin, quinine, DB) or extracts of the bitter herb Gentiana Scabra also induced a dose-dependent rise in GLP-1 release through activation of hTAS2Rs and the canonical taste signalling pathway (Dotson et al 2008, Kim et al 2013, 2014, Suh et al 2015, Yu et al 2015. Intra-gastric administration of bitter agonists (DB, PTC, salicin, propylthiouracil) in mice resulted in increased plasma ghrelin levels, which were partially mediated via activation of a-gustducin and resulted in a short-term increase in food intake.…”

Section: Expression and Function Of Extra-oral Bitter Taste Receptorsmentioning

confidence: 99%

See 2 more Smart Citations

The bitter truth about bitter taste receptors: beyond sensing bitter in the oral cavity

Avau

Depoortere

2015

Acta Physiologica

View full text Add to dashboard Cite

The bitter taste receptor (TAS2R)-family of G-protein-coupled receptors has been identified on the tongue as detectors of bitter taste over a decade ago. In the last few years, they have been discovered in an ever growing number of extra-oral tissues, including the airways, the gut, the brain and even the testis. In tissues that contact the exterior, protective functions for TAS2Rs have been proposed, in analogy to their function on the tongue as toxicity detector. However, TAS2Rs have also been found in internal organs, suggesting other roles for these receptors, perhaps involving as yet unidentified endogenous ligands. The current review gives an overview of the different proposed functions for TAS2Rs in tissues other than the oral cavity; from appetite regulation to the treatment of asthma, regulation of gastrointestinal motility and control of airway innate immunity.

show abstract

Section: Expression and Function Of Extra-oral Bitter Taste Receptorsmentioning

confidence: 72%

“…, Suh et al . ). All together, these results indicate that the enteroendocrine cell is able to sense bitter tastants in an analogue fashion to TRCs on the tongue.…”

Section: Expression and Function Of Extra‐oral Bitter Taste Receptorsmentioning

confidence: 97%

Section: Expression and Function Of Extra-oral Bitter Taste Receptorsmentioning

confidence: 99%

See 1 more Smart Citation

The bitter truth about bitter taste receptors: beyond sensing bitter in the oral cavity

Avau

Depoortere

2015

Acta Physiologica

View full text Add to dashboard Cite

show abstract

“…After chemical analysis, the authors hypothesized that loganic acid (▶ Fig. 5) could be the responsible part of GLP-1 secretion [88].…”

Section: Natural Products As Stimulants Of Glp-1 and Gip Secretionmentioning

confidence: 99%

Modulation of Diabetes by Natural Products and Medicinal Plants via Incretins

et al. 2019

View full text Add to dashboard Cite

Incretins are metabolic hormones released after a meal that increase insulin secretion from pancreatic β-cells. The two main incretins are the intestinal peptides glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. Both induce a decrease in glycemia, slow down the absorption of nutrients, and are inactivated by the enzyme dipeptidyl peptidase-4. Recently, incretin-based therapies have become a useful tool to treat diabetic patients, and different studies have focused on the identification of glucagon-like peptide-1 receptor agonists, including those of natural origin. This review focuses on the new findings of medicinal plants and natural products as possible active agents on the potentiation of incretin receptor signaling. Among these, soluble fiber from species of Plantago and guar gum show promising effects, iridoid derivatives are relevant activators of incretin receptors, and derivatives of cyanidin, especially diglycosylated ones, are an interesting source of dipeptidyl peptidase-4 inhibitors.

show abstract

“…These bitter taste receptors may produce signal transduction pathways that release glucagon-like peptide 1 (GLP-1), an incretin that stimulates insulin production (Dotson et al 2008). One study using a bitter plant extract from the root of Gentiana scabra showed a dose-dependent increase in GLP-1 production in experimental mice (Suh et al 2015). The idea of socalled bitters serving as digestive aids is not new and in some places, aperitifs containing small amounts of bitter plant extracts are still consumed before a meal (Snow and Spelman 2011).…”

Section: Parallels In Folk Disease Concepts and Biomedical Mechanismsmentioning

confidence: 99%

Medicinal Plants of Trinidad and Tobago: Selection of Antidiabetic Remedies

Bullard-Roberts¹

View full text Add to dashboard Cite

Thanks to my Ethnobotany sisters, Cassy Quave and Janna Rose, for making the path smoother and to the Koptur lab for adopting me when I had no lab family left.Thanks to Sasha, Asha and Xtina from the Jaffe and Berry Labs at BBC for sharing their space, equipment and expertise.Thanks to James and Kate at the Quave Lab at Emory University for helping me to navigate through failed trials and strange calculations. Diabetes mellitus (DM) is a group of non-infectious diseases that cause hyperglycemia. DM symptoms were first clinically described by ancient Greek physicians whose prescriptions included plant-based remedies. Today, DM affects >400 million people globally and prevalence rates are rapidly increasing in developing countries where basic healthcare relies on local knowledge of botanical remedies. Many developing countries are home to diverse peoples and plants-providing fodder for varied plant-selection strategies and unique botanical pharmacopoeias.I addressed the plant-selection strategies used in a multi-ethnic, developing country, Trinidad and Tobago (T&T), to ascertain their role in shaping the local antidiabetic pharmacopoeia and to assess their benefits and risks in identifying safe and useful remedies. Using literature reviews, field surveys, and laboratory bioassays, Icompleted three categories of analysis.Ethnobotanical analyses showed that T&T's antidiabetic pharmacopoeia is primarily of recent origin as >50% of the 48 historical DM remedies were Neotropical natives, including congenerics of well-known medicinal Paleotropical genera. ix Nevertheless, conservative knowledge transmission was also evident as several Paleotropical species of T&T's pharmacopoeia, including Momordica charantia and Catharanthus roseus were also used in Africa, India and across the Caribbean.Paleotropical natives with a long history of use are likely to be safer remedies.Ethno-medicinal analyses of the pre-and post-2000 DM remedies of T&T, totaling 99 species, suggest that the centuries-old hot/cold folk disease-model was the model predominantly used in plant-selection. Parallels found between T&T folk concepts and biomedical mechanisms of DM provide probable bases for efficacy but the chronic use of purgatives and bitter-tasting plants is likely to be risky.Phytochemical analyses revealed that 69% of the tested plant extracts contained phenolic compounds, with more than half producing >80% alpha-glucosidase inhibition.Phenolic content and alpha-glucosidase inhibition were strongly correlated among food plants used as medicines, suggesting higher probability of selection as a result of nontarget effects. The medicinal use of food plants may provide the best margins of safety and efficacy in identifying antidiabetic remedies.Together, these analyses showed how culture-specific plant-selection strategies can identify safe, useful remedies for developing countries to address their increasing DM prevalence in a cost-effective and sustainable manner.x Table 3 Regions of the Indian sub-continent from which indentured laborers...

show abstract

A bitter herbal medicine Gentiana scabra root extract stimulates glucagon-like peptide-1 secretion and regulates blood glucose in db/db mouse

Cited by 46 publications

References 18 publications

The bitter truth about bitter taste receptors: beyond sensing bitter in the oral cavity

The bitter truth about bitter taste receptors: beyond sensing bitter in the oral cavity

Modulation of Diabetes by Natural Products and Medicinal Plants via Incretins

Medicinal Plants of Trinidad and Tobago: Selection of Antidiabetic Remedies

Contact Info

Product

Resources

About