A bird's eye view of <scp>NK</scp> cell receptor interactions with their <scp>MHC</scp> class I ligands

Saunders, Philippa M.; Vivian, J.P.; O’Connor, Geraldine M.; Sullivan, Lucy C.; Pymm, Phillip; Rossjohn, Jamie; Brööks, Andrëw G.

doi:10.1111/imr.12319

Cited by 94 publications

(97 citation statements)

References 140 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…49 Interestingly, higher expression of the KIR3DL1*015 allele is observed in HIV-infected adult African Americans compared with European Americans, and this particular allele has higher binding for HLA-Bw4. 18,50 Future studies of eBL etiology will incorporate HLA and KIR genotypes in individual assessments of NK cell function, because higher responses to Pf-iRBCs have been reported for KIR3DL2 pos NK cells. 51 In addition to shifts in NK cell subset proportions and expression of licensing markers, we evaluated NKp30 and NKp46, which can be activated by the Pf erythrocyte membrane protein 1 (reviewed in Kruse et al 22 ) and induce cytotoxic activity against Pf-iRBCs.…”

Section: Discussionmentioning

confidence: 99%

“…[13][14][15][16] Killer cell immunoglobulin-like receptors (KIRs; reviewed in Lanier 17 and Saunders et al 18 ) interact with human leukocyte antigen (HLA) class I molecules for target cell recognition, 15,19,20 distinguishing "self" from "nonself." NK cells also receive coordinated signals from other cell surface receptors that determine their cytolytic function or lack thereof: the NKG2 family induces inhibitory signals (via NKG2A) or activation signals (via NKG2C and NKG2D), 21 and natural cytotoxicity receptors (NCRs) are crucial for triggering cytotoxic activity and targeted cell death (reviewed in Kruse et al 22 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Poorly cytotoxic terminally differentiated CD56negCD16pos NK cells accumulate in Kenyan children with Burkitt lymphomas

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Poorly cytotoxic terminally differentiated CD56negCD16pos NK cells accumulate in Kenyan children with Burkitt lymphomas

et al. 2018

View full text Add to dashboard Cite

show abstract

“…In contrast to the T-cell receptor, KIR bind to the upper face of the HLA class I molecule, creating contact with the N-terminal part of the a1 helix, the C-terminal part of the a1 helix, and the bound peptide. 154 Genetic variation in the class I a1 helix governs the three major epitopes perceived by KIR, HLA-C1, -C2 and -Bw4. The inhibitory KIR2DL1 and KIR2DL2/3 and the stimulating KIR2DS1, KIR2DS2 and KIR2DS4 interact divergently with the reciprocally unique C1 or C2 epitopes carried by all HLA-C allotypes and a small subset of HLA-B molecules.…”

Section: Hla and Amyotrophic Lateral Sclerosismentioning

confidence: 99%

The immunogenetics of neurological disease

2017

View full text Add to dashboard Cite

Summary Genes encoding antigen‐presenting molecules within the human major histocompatibility complex (MHC) account for the highest component of genetic risk for many neurological diseases, such as multiple sclerosis, neuromyelitis optica, Parkinson's disease, Alzheimer's disease, schizophrenia, myasthenia gravis and amyotrophic lateral sclerosis. Myriad genetic, immunological and environmental factors may contribute to an individual's susceptibility to neurological disease. Here, we review and discuss the decades long research on the influence of genetic variation at the MHC locus and the role of immunogenetic killer cell immunoglobulin‐like receptor (KIR) loci in neurological diseases, including multiple sclerosis, neuromyelitis optica, Parkinson's disease, Alzheimer's disease, schizophrenia, myasthenia gravis and amyotrophic lateral sclerosis. The findings of immunogenetic association studies are consistent with a polygenic model of inheritance in the heterogeneous and multifactorial nature of complex traits in various neurological diseases. Future investigation is highly recommended to evaluate both coding and non‐coding variation in immunogenetic loci using high‐throughput high‐resolution next‐generation sequencing technologies in diverse ethnic groups to fully appreciate their role in neurological diseases.

show abstract

“…These bind to the upper face of the HLA class I molecule, making contact with the amino-terminal part of the α 1 helix, the carboxy-terminal part of the α 1 helix, and the bound peptide (2). Key polymorphisms in the α 1 helix determine the three major epitopes recognized by KIR.…”

Section: Introductionmentioning

confidence: 99%

Class I HLA haplotypes form two schools that educate NK cells in different ways

et al. 2016

View full text Add to dashboard Cite

Summary Natural killer (NK) cells are lymphocytes having vital functions in innate and adaptive immunity, as well as placental reproduction. Controlling education and functional activity of human NK cells are various receptors that recognize HLA class I on the surface of tissue cells. Epitopes of polymorphic HLA-A,-B and –C are recognized by equally diverse killer cell immunoglobulin-like receptors (KIR). In addition, a peptide cleaved from the leader sequence of HLA-A,-B or –C must bind to HLA-E for it to become a ligand for the conserved CD94:NKG2A receptor. Methionine/threonine dimorphism at position -21 of the leader sequence divides HLA-B allotypes into a majority having -21T that do not supply HLA-E binding peptides and a minority having -21M, that do. Genetic analysis of human populations worldwide shows how haplotypes with -21M HLA-B rarely encode the KIR ligands: Bw4+HLA-B and C2+HLA-C KIR. Thus there are two fundamental forms of HLA haplotype: one preferentially supplying CD94:NKG2A ligands, the other preferentially supplying KIR ligands. -21 HLA-B dimorphism divides the human population into three groups: M/M, M/T and T/T. Mass cytometry and assays of immune function, shows how M/M and M/T individuals have CD94:NKG2A+ NK cells which are better educated, phenotypically more diverse and functionally more potent than those in T/T individuals. Fundamental new insights are given to genetic control of NK cell immunity and the evolution that has limited the number of NK cell receptor ligands encoded by an HLA haplotype. These finding suggest new ways to dissect the numerous clinical associations with HLA class I.

show abstract

A bird's eye view of NK cell receptor interactions with their MHC class I ligands

Cited by 94 publications

References 140 publications

Poorly cytotoxic terminally differentiated CD56negCD16pos NK cells accumulate in Kenyan children with Burkitt lymphomas

Poorly cytotoxic terminally differentiated CD56negCD16pos NK cells accumulate in Kenyan children with Burkitt lymphomas

The immunogenetics of neurological disease

Class I HLA haplotypes form two schools that educate NK cells in different ways

Contact Info

Product

Resources

About