A biphasic calcium phosphate coating for potential drug delivery affects early osseointegration of titanium implants

Kämmerer, Till; Palarie, Victor; Schiegnitz, Eik; Topalo, Valentin; Schröter, Andrea; Kämmerer, Peer W.

doi:10.1111/jop.12464

Cited by 21 publications

(11 citation statements)

References 31 publications

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“…In addition to acting as drug carriers, they can also serve as a reservoir for calcium and phosphate ions, which are necessary for bone homeostasis and mineral formation under physiological conditions, attributing to their osteogenic and osteoinductive properties [104][105][106][107][108][109][110]. Furthermore, the intrinsic porosity of these structures not only makes them the ideal drug carriers, but also facilitates mass transport, cell infiltration, and tissue ingrowth [111][112][113][114][115][116]. For instance, Levengood et al have used a biphasic calcium scaffold with heterogeneous porous structures, which was further impregnated with gelatin microparticles containing BMP-2 [117].…”

Section: Bone-mimetic Biomaterials As Carriers-mentioning

confidence: 99%

Biomaterial-assisted local and systemic delivery of bioactive agents for bone repair

2019

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Although bone tissues possess an intrinsic capacity for repair, there are cases where bone healing is either impaired or insufficient, such as fracture non-union, osteoporosis, osteomyelitis, and cancers. In these cases, treatments like surgical interventions are used, either alone or in combination with bioactive agents, to promote tissue repair and manage associated clinical complications. Improving the efficacy of bioactive agents often requires carriers, with biomaterials being a pivotal player. In this review, we discuss the role of biomaterials in realizing the local and systemic delivery of biomolecules to the bone tissue. The versatility of biomaterials enables design of carriers with the desired loading efficiency, release profile, and on-demand delivery. Besides local administration, systemic administration of drugs is necessary to combat diseases like osteoporosis, warranting bone-targeting drug delivery systems. Thus, chemical moieties with the affinity towards bone extracellular matrix components like apatite minerals have been widely utilized to create bone-targeting carriers with better biodistribution, which cannot be achieved by the drugs alone. Bone-targeting carriers combined with the desired drugs or bioactive agents have been extensively investigated to enhance bone healing while minimizing off-target effects. Herein, these advancements in the field have been systematically reviewed.

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Section: Bone-mimetic Biomaterials As Carriers-mentioning

confidence: 99%

Biomaterial-assisted local and systemic delivery of bioactive agents for bone repair

2019

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“…Titanium and its alloys are bio-inert, having a high corrosion resistance, and sufficient mechanical strength for most indications. 144,145 In this case, Ti is commonly employed as the substrate, coated with brittle, but bioactive CaP. Gross et al 146 found that titanium promoted the plastic deformation of the coating compared to stainless steel and Co-Cr substrate during contact nanofatigue.…”

Section: Coating Cap On Metallic Materialsmentioning

confidence: 99%

Biological properties of calcium phosphate biomaterials for bone repair: a review

Chen

2018

RSC Adv.

145

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“…The next potential parameters of influence in all groups were the rough-surface implants with CaP coatings. These have already shown putative advantages such as vertical osteoconductive characteristics in terms of osseous growth during the early healing phases [ 24 , 26 ]. It was also reported that rough-surface implants or implants with hydroxyapatite surfaces together with membrane techniques (GBR) will lead to a higher degree of bony healing when compared to implants with smooth surfaces [ 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…In each semi-mandible, 1-2 4.3 × 12 mm implants (total n = 46) were inserted (Alphatech® Tube-line BONITex®, FMZ GmbH, Rostock, Germany) ( Figure 3 ). BONITex combines sandblasting, acid-etched implants with a thin, quick absorbable calcium phosphate (CaP) layer [ 24 – 26 ]. All circular defects were randomly filled with different collagen materials solely or in combination with growth factors or PDLSC by the use of a sterile spatula.…”

Section: Methodsmentioning

confidence: 99%

Guided Bone Regeneration Using Collagen Scaffolds, Growth Factors, and Periodontal Ligament Stem Cells for Treatment of Peri-Implant Bone Defects In Vivo

Kämmerer

Scholz

Baudisch

et al. 2017

Stem Cells International

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Introduction The aim of the study was an evaluation of different approaches for guided bone regeneration (GBR) of peri-implant defects in an in vivo animal model. Materials and Methods In minipigs (n = 15), peri-implant defects around calcium phosphate- (CaP-; n = 46) coated implants were created and randomly filled with (1) blank, (2) collagen/hydroxylapatite/β-tricalcium phosphate scaffold (CHT), (3) CHT + growth factor cocktail (GFC), (4) jellyfish collagen matrix, (5) jellyfish collagen matrix + GFC, (6) collagen powder, and (7) collagen powder + periodontal ligament stem cells (PDLSC). Additional collagen membranes were used for coverage of the defects. After 120 days of healing, bone growth was evaluated histologically (bone to implant contact (BIC;%)), vertical bone apposition (VBA; mm), and new bone height (NBH; %). Results In all groups, new bone formation was seen. Though, when compared to the blank group, no significant differences were detected for all parameters. BIC and NBH in the group with collagen matrix as well as the group with the collagen matrix + GFC were significantly less when compared to the collagen powder group (all: p < 0.003). Conclusion GBR procedures, in combination with CaP-coated implants, will lead to an enhancement of peri-implant bone growth. There was no additional significant enhancement of osseous regeneration when using GFC or PDLSC.

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A biphasic calcium phosphate coating for potential drug delivery affects early osseointegration of titanium implants

Abstract: The CaP coating has putative additional advantages in the early osseoconduction phases. It seems suitable for a feasible and clinical applicable bioactivation.

Cited by 21 publications

References 31 publications

Biomaterial-assisted local and systemic delivery of bioactive agents for bone repair

Biomaterial-assisted local and systemic delivery of bioactive agents for bone repair

Biological properties of calcium phosphate biomaterials for bone repair: a review

Guided Bone Regeneration Using Collagen Scaffolds, Growth Factors, and Periodontal Ligament Stem Cells for Treatment of Peri-Implant Bone Defects In Vivo

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