A biotin-guided fluorescent-peptide drug delivery system for cancer treatment

Kim, Tae‐Young; Jeon, Hosang; Lê, Hòa; Kim, Tae Woo; Kang, Chulhun; Kim, Jong Seung

doi:10.1039/c4cc02878c

Cited by 50 publications

(38 citation statements)

References 27 publications

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“…The varied uptake level of Bio-cage@Ru in different cells should be attributed to their different expression level of biotin receptors[42][43][44]. To further demonstrate the role of biotin/receptor-mediated targeting on the selective uptake of Bio-cage@Ru, we used excess biotin to block biotin receptors on HepG2 cells and determined the uptake efficiency of Biocage@Ru in HepG2 cells.…”

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confidence: 99%

A multifunctional DNA origami as carrier of metal complexes to achieve enhanced tumoral delivery and nullified systemic toxicity

et al. 2016

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confidence: 99%

A multifunctional DNA origami as carrier of metal complexes to achieve enhanced tumoral delivery and nullified systemic toxicity

et al. 2016

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“…5). 15 Holliday junction (HJ) inhibitor peptide 2 was used as a model peptide drug that shows promise as an antimicrobial and anticancer agent. To investigate the role of the biotin within the conjugate, both biotin-receptor-positive HepG2 cells and biotin-receptor-negative W138 cells were treated with 6 .…”

Section: Design Of Targeted Fluorescent Prodrug Conjugatesmentioning

confidence: 99%

Fluorogenic reaction-based prodrug conjugates as targeted cancer theranostics

et al. 2018

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Theranostic systems are receiving ever-increasing attention due to their potential therapeutic utility, imaging enhancement capability, and promise for advancing the field of personalized medicine, particularly as it relates to the diagnosis, staging, and treatment of cancer. In this Tutorial Review, we provide an introduction to the concepts of theranostic drug delivery effected via use of conjugates that are able to target cancer cells selectively, provide cytotoxic chemotherapeutics, and produce readily monitored imaging signals in vitro and in vivo. The underlying design concepts, requiring the synthesis of conjugates composed of imaging reporters, masked chemotherapeutic drugs, cleavable linkers, and cancer targeting ligands, are discussed. Particular emphasis is placed on highlighting the potential benefits of fluorogenic reaction-based targeted systems that are activated for both imaging and therapy by cellular entities, e.g., thiols, reactive oxygen species and enzymes, which are present at relatively elevated levels in tumour environments, physiological characteristics of cancer, e.g., hypoxia and acidic pH. Also discussed are systems activated by an external stimulus, such as light. The work summarized in this Tutorial Review will help define the role fluorogenic reaction-based, cancer-targeting theranostics may have in advancing drug discovery efforts, as well as improving our understanding of cellular uptake and drug release mechanisms.

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“…Biotin, also known as vitamin H, is able to target the tumors by attaching to the SMVT receptors in tumor cells. 17,18,[20][21][22] As a water-soluble drug, DOX$HCl can hardly be encapsulated by PLGA NPs via hydrophobic interaction, so the desalted process was prerequisite to transform the hydrophilic drug to hydrophobic drug. Because triethylamine was a volatile weak base, the DOX could escape from being destroyed and the excess of triethylamine would be easily evaporated.…”

Section: Preparation Of the Npsmentioning

confidence: 99%

“…20 Profoundly, it has been reported that SMVT transporters are overexpressed in many tumor cells including HepG2 cells. [21][22][23] Thus, the cell experiments in this study were exerted on HepG2 cells.…”

Section: Introductionmentioning

confidence: 99%