A biorefinery approach to obtain docosahexaenoic acid and docosapentaenoic acid n-6 from Schizochytrium using high performance countercurrent chromatography

Bárcenas-Pérez, Daniela; Lukeš, Martin; Hrouzek, Pavel; Kubáč, David; Kopeckỳ, J.; Kaštánek, Petr; Cheel, José

doi:10.1016/j.algal.2021.102241

Cited by 14 publications

(6 citation statements)

References 44 publications

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“…Nevertheless, these rats exhibited a defect in spatial retention, although they had a longer escape latency than those given DHA [146]. Recently, n-6 DPA has been produced using microalgae and commercialized; however, the metabolic and physiological functions and impacts on health of this fatty acid has not been well studied [147][148][149], and therefore, further investigations are warranted to explore the potential benefits vs. negative effects of this fatty acid on human health.…”

Section: Cancer Prevention and Treatmentmentioning

confidence: 99%

Health Benefits, Food Applications, and Sustainability of Microalgae-Derived N-3 PUFA

Liu¹,

Ren²,

Fan³

et al. 2022

Foods

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Today’s consumers are increasingly aware of the beneficial effects of n-3 PUFA in preventing, delaying, and intervening various diseases, such as coronary artery disease, hypertension, diabetes, inflammatory and autoimmune disorders, neurodegenerative diseases, depression, and many other ailments. The role of n-3 PUFA on aging and cognitive function is also one of the hot topics in basic research, product development, and clinical applications. For decades, n-3 PUFA, especially EPA and DHA, have been supplied by fish oil and seafood. With the continuous increase of global population, awareness about the health benefits of n-3 PUFA, and socioeconomic improvement worldwide, the supply chain is facing increasing challenges of insufficient production. In this regard, microalgae have been well considered as promising sources of n-3 PUFA oil to mitigate the supply shortages. The use of microalgae to produce n-3 PUFA-rich oils has been explored for over two decades and some species have already been used commercially to produce n-3 PUFA, in particular EPA- and/or DHA-rich oils. In addition to n-3 PUFA, microalgae biomass contains many other high value biomolecules, which can be used in food, dietary supplement, pharmaceutical ingredient, and feedstock. The present review covers the health benefits of n-3 PUFA, EPA, and DHA, with particular attention given to the various approaches attempted in the nutritional interventions using EPA and DHA alone or combined with other nutrients and bioactive compounds towards improved health conditions in people with mild cognitive impairment and Alzheimer’s disease. It also covers the applications of microalgae n-3 PUFA in food and dietary supplement sectors and the economic and environmental sustainability of using microalgae as a platform for n-3 PUFA-rich oil production.

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Section: Cancer Prevention and Treatmentmentioning

confidence: 99%

Health Benefits, Food Applications, and Sustainability of Microalgae-Derived N-3 PUFA

Liu¹,

Ren²,

Fan³

et al. 2022

Foods

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“…However, it should be noted that DPA also exists in the form of n6 isomer and in this form it is produced by, e.g., marine microalgae from Schizochytrium spp. [ 12 ]. An essential ALA is a precursor for the production of n3 long-chain (LC) PUFAs in human nutrition [ 10 , 13 ].…”

Section: Milk Fatty Acids and Indices Used For The Evaluation Of Milk Fat Qualitymentioning

confidence: 99%

Alternative and Unconventional Feeds in Dairy Diets and Their Effect on Fatty Acid Profile and Health Properties of Milk Fat

Hadrová

Sedláková

Křížová

et al. 2021

Animals

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Milk fat is an important nutritional compound in the human diet. From the health point of view, some fatty acids (FAs), particularly long-chain PUFAs such as EPA and DHA, have been at the forefront of interest due to their antibacterial, antiviral, anti-inflammatory, and anti-tumor properties, which play a positive role in the prevention of cardiovascular diseases (CVD), as well as linoleic and γ-linolenic acids, which play an important role in CVD treatment as essential components of phospholipids in the mitochondria of cell membranes. Thus, the modification of the FA profile—especially an increase in the concentration of polyunsaturated FAs and n-3 FAs in bovine milk fat—is desirable. The most effective way to achieve this goal is via dietary manipulations. The effects of various strategies in dairy nutrition have been thoroughly investigated; however, there are some alternative or unconventional feedstuffs that are often used for purposes other than basic feeding or modifying the fatty acid profiles of milk, such as tanniferous plants, herbs and spices, and algae. The use of these foods in dairy diets and their effects on milk fatty acid profile are reviewed in this article. The contents of selected individual FAs (atherogenic, rumenic, linoleic, α-linolenic, eicosapentaenoic, and docosahexaenoic acids) and their combinations; the contents of n3 and n6 FAs; n6/n3 ratios; and atherogenic, health-promoting and S/P indices were used as criteria for assessing the effect of these feeds on the health properties of milk fat.

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“…These organisms are able to produce a wide range of industrially relevant products, such as carotenoids (astaxanthin, β-carotene, lutein) [ 2 , 3 , 4 ], pigments (phycobiliproteins, e.g., phycocyanin) [ 5 ], polysaccharides (hydro colloids, e.g., sulphated polysaccharides) [ 6 ], vitamins (vitamin B12) [ 7 ] and starch [ 8 ]. They can assemble various lipids, including polyunsaturated and omega-3 fatty acids (e.g., eicosapentaenoic acid or docosahexaenoic acid) [ 9 , 10 ], trans-fatty acids [ 11 ] and fatty acid methyl esters [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Strain Development in Microalgal Biotechnology—Random Mutagenesis Techniques

Bleisch

Freitag

Ihadjadene

et al. 2022

Life

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Microalgal biomass and metabolites can be used as a renewable source of nutrition, pharmaceuticals and energy to maintain or improve the quality of human life. Microalgae’s high volumetric productivity and low impact on the environment make them a promising raw material in terms of both ecology and economics. To optimize biotechnological processes with microalgae, improving the productivity and robustness of the cell factories is a major step towards economically viable bioprocesses. This review provides an overview of random mutagenesis techniques that are applied to microalgal cell factories, with a particular focus on physical and chemical mutagens, mutagenesis conditions and mutant characteristics.

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A biorefinery approach to obtain docosahexaenoic acid and docosapentaenoic acid n-6 from Schizochytrium using high performance countercurrent chromatography

Cited by 14 publications

References 44 publications

Health Benefits, Food Applications, and Sustainability of Microalgae-Derived N-3 PUFA

Health Benefits, Food Applications, and Sustainability of Microalgae-Derived N-3 PUFA

Alternative and Unconventional Feeds in Dairy Diets and Their Effect on Fatty Acid Profile and Health Properties of Milk Fat

Strain Development in Microalgal Biotechnology—Random Mutagenesis Techniques

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