A bioprosthetic heart valve prepared by copolymerization of 2-isocyanatoethyl methacrylate modified pericardium and functional monomer

Cheng, Zheng; Ding, Kailei; Huang, Xueyu; Yang, Li; Lei, Yang; Wang, Yunbing

doi:10.1016/j.compositesb.2022.109922

Cited by 13 publications

(5 citation statements)

References 42 publications

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“…Furthermore, the hydrodynamic performance and durability of ICM crosslinked BHV were satisfied with ISO 5840, which indicated the efficiency and application potential of ICM-based double-bond crosslinking strategy for BHVs [ 109 ]. To confer the BHVs with antithrombotic property, hydrophilic polymers were grafted on BHVs through copolymerization of monomers (hydroxyethyl methacrylate and poly(ethylene glycol) dimethacrylate) and ICM-modified pericardial matrix to resist the adsorption of blood components [ 110 , 111 ]. With the introduction of polymers, the component stability of BHVs against enzymatic degradation was markedly enhanced [ 110 , 111 ].…”

Section: Nonglutaraldehyde Crosslinking and Modification Strategies F...mentioning

confidence: 99%

“…To confer the BHVs with antithrombotic property, hydrophilic polymers were grafted on BHVs through copolymerization of monomers (hydroxyethyl methacrylate and poly(ethylene glycol) dimethacrylate) and ICM-modified pericardial matrix to resist the adsorption of blood components [ 110 , 111 ]. With the introduction of polymers, the component stability of BHVs against enzymatic degradation was markedly enhanced [ 110 , 111 ]. Cytomembrane biomimetic phosphorylcholine moiety was also introduced on BHV through copolymerization of 2-methacryloyloxyethyl phosphorylcholine and ICM-modified matrix [ 112 ].…”

Section: Nonglutaraldehyde Crosslinking and Modification Strategies F...mentioning

confidence: 99%

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Recent progress in functional modification and crosslinking of bioprosthetic heart valves

Zheng,

Yang,

Wang

2023

Regenerative Biomaterials

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Valvular heart disease (VHD), clinically manifested as stenosis and regurgitation of native heart valve, is one of the most prevalent cardiovascular diseases with high mortality. Heart valve replacement surgery has been recognized as golden standard for the treatment of VHD. Owing to the clinical application of transcatheter heart valve replacement technic and the excellent hemodynamic performance of bioprosthetic heart valves (BHVs), implantation of BHVs has been increasing over recent years and gradually became the preferred choice for the treatment of VHD. However, BHVs might fail within 10-15 years due to structural valvular degeneration (SVD), which was greatly associated with drawbacks of glutaraldehyde crosslinked BHVs, including cytotoxicity, calcification, component degradation, mechanical failure, thrombosis and immune response. To prolong the service life of BHVs, much effort has been devoted to overcoming the drawbacks of BHVs and reducing the risk of SVD. In this review, we summarized and analyzed the research and progress on: (1) modification strategies based on glutaraldehyde crosslinked BHVs; (2) nonglutaraldehyde crosslinking strategies for BHVs.

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Section: Nonglutaraldehyde Crosslinking and Modification Strategies F...mentioning

confidence: 99%

Section: Nonglutaraldehyde Crosslinking and Modification Strategies F...mentioning

confidence: 99%

Recent progress in functional modification and crosslinking of bioprosthetic heart valves

Zheng,

Yang,

Wang

2023

Regenerative Biomaterials

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“…A series of pioneer studies of dry‐tissue storage of BHVs have been investigated by Wang and co‐workers. [ 114,116–125 ] To realize the dry‐tissue storage of the conventional Glut‐treated BHVs, a hydrogel hybrid Glut‐treated porcine pericardium was developed. [ 116 ] Through the in situ polymerization of monomers of sodium acrylate, 2‐methacryloyloxyethyl phosphorylcholine, or acryloyloxyethyltrimethyl ammonium chloride in the Glut‐treated porcine pericardium, three types of hydrogel hybrid Glut‐treated porcine pericardium were prepared.…”

Section: Artificial Heart Valvesmentioning

confidence: 99%

Development of Innovative Biomaterials and Devices for the Treatment of Cardiovascular Diseases

Wang

Yang

et al. 2022

Advanced Materials

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Cardiovascular diseases have become the leading cause of death worldwide. The increasing burden of cardiovascular diseases has become a major public health problem and how to carry out efficient and reliable treatment of cardiovascular diseases has become an urgent global problem to be solved. Recently, implantable biomaterials and devices, especially minimally invasive interventional ones, such as vascular stents, artificial heart valves, bioprosthetic cardiac occluders, artificial graft cardiac patches, atrial shunts, and injectable hydrogels against heart failure, have become the most effective means in the treatment of cardiovascular diseases. Herein, an overview of the challenges and research frontier of innovative biomaterials and devices for the treatment of cardiovascular diseases is provided, and their future development directions are discussed.

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“…The ex vivo circulation blood contacting test was conducted according to a previous report. 22,35 Pentobarbital with a dose of 30 mg kg À1 was administered through auricular vein injection to anesthetize a male New Zealand rabbit. To carry out systemic anticoagulation, heparin was injected through the auricular vein with a dose of 100 U kg À1 .…”

Section: Ex Vivo Circulation Blood Contacting Testmentioning

confidence: 99%

A functionalized biological heart valve by double bond crosslinking with enhanced biocompatibility and antithrombogenicity

et al. 2022

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A bioprosthetic heart valve prepared by copolymerization of 2-isocyanatoethyl methacrylate modified pericardium and functional monomer

Cited by 13 publications

References 42 publications

Recent progress in functional modification and crosslinking of bioprosthetic heart valves

Recent progress in functional modification and crosslinking of bioprosthetic heart valves

Development of Innovative Biomaterials and Devices for the Treatment of Cardiovascular Diseases

A functionalized biological heart valve by double bond crosslinking with enhanced biocompatibility and antithrombogenicity

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