A bioorthogonal chemical reporter for fatty acid synthase–dependent protein acylation

Abstract

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Fatty acid synthase (FASN) signalome: A molecular guide for precision oncology

“…De novo synthesized palmitoyl-CoA accumulates intracellularly in the range of 0.1-10 lmolÁL À1 and serves as a palmitoylation donor. Although FASN actively contributes to the endogenous bioavailability of de novo synthesized palmitoyl-CoA, the role of FASN as a regulator of protein acylation has been largely overlooked [311]. Pharmacological blockade of FASN has been shown to suppress the palmitoylation of several cancer-related proteins such as EGFR, MYD88, AKT and the estrogen receptor, negatively affecting their stability, cellular localization, functionality and interactivity [312][313][314][315][316].…”