A biomimetic magnetosome: formation of iron oxide within carboxylic acid terminated polymersomes

Bain, Jennifer; Legge, Christopher; Beattie, Deborah L.; Sahota, Annie; Dirks, Catherine E.; Lovett, Joseph R.; Staniland, Sarah S.

doi:10.1039/c9nr00498j

Cited by 18 publications

(12 citation statements)

References 53 publications

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“…There are very few manuscripts regarding magnetoliposomes containing BMNPs. In fact, only magnetoliposomes containing Mms6-mediated BMNPs have been described so far, and their production is intended for magnetic resonance imaging [28][29][30]. Therefore, to our understanding, this is the first attempt to produce magnetoliposomes containing MamC-mediated BMNPs for a directed delivery of oxaliplatin, and it is also one of the first tryout for the local delivery of this drug, which may be of potential interest to locally treat CRC.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Magnetoliposomes as Oxaliplatin Nanocarriers: In Vitro Study for Potential Application in Colon Cancer

et al. 2020

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Current chemotherapy for colorectal cancer (CRC) includes the use of oxaliplatin (Oxa), a first-line cytotoxic drug which, in combination with irinotecan/5-fluorouracil or biologic agents, increases the survival rate of patients. However, the administration of this drug induces side effects that limit its application in patients, making it necessary to develop new tools for targeted chemotherapy. MamC-mediated biomimetic magnetic nanoparticles coupled with Oxa (Oxa-BMNPs) have been previously demonstrated to efficiently reduce the IC50 compared to that of soluble Oxa. However, their strong interaction with the macrophages revealed toxicity and possibility of aggregation. In this scenario, a further improvement of this nanoassembly was necessary. In the present study, Oxa-BMNPs nanoassemblies were enveloped in phosphatidylcholine unilamellar liposomes (both pegylated and non-pegylated). Our results demonstrate that the addition of both a lipid cover and further pegylation improves the biocompatibility and cellular uptake of the Oxa-BMNPs nanoassemblies without significantly reducing their cytotoxic activity in colon cancer cells. In particular, with the pegylated magnetoliposome nanoformulation (a) hemolysis was reduced from 5% to 2%, being now hematocompatibles, (b) red blood cell agglutination was reduced, (c) toxicity in white blood cells was eliminated. This study represents a truly stepforward in this area as describes the production of one of the very few existing nanoformulations that could be used for a local chemotherapy to treat CRC.

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Section: Introductionmentioning

confidence: 99%

Biomimetic Magnetoliposomes as Oxaliplatin Nanocarriers: In Vitro Study for Potential Application in Colon Cancer

et al. 2020

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“…In another paper, Bain et al (2019) documented a combination of 2 diblock co-polymers made up from PEG and carboxylic acid terminated poly (2-methacryloxyethyl phosphorylcholine) (PMPC) (called polymersome). PMM28 magneto-polymersomes (PMM28Fe) showed a 6 ° C increase in temperature during magnetic hyperthermia in vitro, resulting in an intrinsic loss power (ILP) of 3.7 nHm 2 kg −1 that offers the added potential for further tuning and functionalization for imaging and drug delivery purposes [ 243 ]. Aouidat et al (2019) reported a new Gd(III)–biopolymer—Au(III) complex synthesis that acts as a key component of Gold core-shell nanoparticles (Gd(@AuNPs).…”

Section: Stimuli-responsive Polymeric Nanocarriers For Bioimagingmentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

et al. 2020

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In the past few decades, polymeric nanocarriers have been recognized as promising tools and have gained attention from researchers for their potential to efficiently deliver bioactive compounds, including drugs, proteins, genes, nucleic acids, etc., in pharmaceutical and biomedical applications. Remarkably, these polymeric nanocarriers could be further modified as stimuli-responsive systems based on the mechanism of triggered release, i.e., response to a specific stimulus, either endogenous (pH, enzymes, temperature, redox values, hypoxia, glucose levels) or exogenous (light, magnetism, ultrasound, electrical pulses) for the effective biodistribution and controlled release of drugs or genes at specific sites. Various nanoparticles (NPs) have been functionalized and used as templates for imaging systems in the form of metallic NPs, dendrimers, polymeric NPs, quantum dots, and liposomes. The use of polymeric nanocarriers for imaging and to deliver active compounds has attracted considerable interest in various cancer therapy fields. So-called smart nanopolymer systems are built to respond to certain stimuli such as temperature, pH, light intensity and wavelength, and electrical, magnetic and ultrasonic fields. Many imaging techniques have been explored including optical imaging, magnetic resonance imaging (MRI), nuclear imaging, ultrasound, photoacoustic imaging (PAI), single photon emission computed tomography (SPECT), and positron emission tomography (PET). This review reports on the most recent developments in imaging methods by analyzing examples of smart nanopolymers that can be imaged using one or more imaging techniques. Unique features, including nontoxicity, water solubility, biocompatibility, and the presence of multiple functional groups, designate polymeric nanocues as attractive nanomedicine candidates. In this context, we summarize various classes of multifunctional, polymeric, nano-sized formulations such as liposomes, micelles, nanogels, and dendrimers.

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“…However, one possible solution to this issue is based on the clustering of many superparamagnetic nanocrystals into larger nanoparticles that preserve the superparamagnetic properties, while possessing enhanced magnetic moment that is suitable for effective spatial guidance of the particles in suspension. Therefore, different approaches of superparamagnetic nanoparticle clustering have been proposed in the last two decades, including: one-pot nanoparticle cluster synthesis method, solvothermal methods, chemical cross-linking of nanoparticles in the cluster, preparation of composite nanoparticle clusters with polymers, and emulsion/evaporation-based clustering of hydrophobic nanoparticles, among other strategies ( Figure 6 ) [ 29 , 41 , 42 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 ]. Krasia-Christoforou et al has recently presented an elegant topical review on magnetic nanoparticle clustering that is available for further reading [ 88 ].…”

Section: Natural and Bioinspired Synthetic Approaches To Form Magnetic Nanochainsmentioning

confidence: 99%

Bioinspired Magnetic Nanochains for Medicine

Kralj

Marchesan

2021

Pharmaceutics

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Superparamagnetic iron oxide nanoparticles (SPIONs) have been widely used for medicine, both in therapy and diagnosis. Their guided assembly into anisotropic structures, such as nanochains, has recently opened new research avenues; for instance, targeted drug delivery. Interestingly, magnetic nanochains do occur in nature, and they are thought to be involved in the navigation and geographic orientation of a variety of animals and bacteria, although many open questions on their formation and functioning remain. In this review, we will analyze what is known about the natural formation of magnetic nanochains, as well as the synthetic protocols to produce them in the laboratory, to conclude with an overview of medical applications and an outlook on future opportunities in this exciting research field.

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A biomimetic magnetosome: formation of iron oxide within carboxylic acid terminated polymersomes

Abstract: Bioinspired macromolecules can aid nucleation and crystallisation of minerals by mirroring processes observed in nature.

Cited by 18 publications

References 53 publications

Biomimetic Magnetoliposomes as Oxaliplatin Nanocarriers: In Vitro Study for Potential Application in Colon Cancer

Biomimetic Magnetoliposomes as Oxaliplatin Nanocarriers: In Vitro Study for Potential Application in Colon Cancer

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

Bioinspired Magnetic Nanochains for Medicine

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