A Biomimetic Lubricating Nanosystem with Responsive Drug Release for Osteoarthritis Synergistic Therapy

Abstract

Osteoarthritis (OA) is associated with lubrication failure of articular cartilage and severe inflammatory response of joint capsule. Synergistic therapy combining joint lubrication and anti-inflammation emerges as a novel treatment of OA. In this study, bioinspired by ultralow friction of natural articular synovial fluid and mussel adhesion chemistry, a biomimetic nanosystem with dual functions of enhanced lubrication and stimuli-responsive drug release is developed. A dopamine mediated strategy realizes one step biomimetic grafting of hyaluronic acid (HA) on fluorinated graphene. The polymer modified sheets exhibit highly efficient near-infrared absorption, and show steady lubrication with a long time under various working conditions, in which the coefficient of friction is reduced by 75% compared to H 2 O. Diclofenac sodium (DS) with a high loading capacity of 29.2% is controllably loaded, and responsive and sustained drug release is adjusted by near-infrared light. Cell experiments reveal that the lubricating nanosystem is taken up by endocytosis, and anti-inflammation results confirm that the nanosystem inhibits osteoarthritis deterioration by upregulating cartilage anabolic gene and downregulating catabolic proteases and pain-related gene. This work proposes a promising biomimetic approach to integrate polymer modified fluorinated graphene as a dual-functional nanosystem for effective synergistic therapy of OA.

Controlled Growing of Graphdiyne Film for Friction Reduction and Antiwear

“…The detailed C 1s spectrum in Figure 3f showed sp 2 (C�C) at a binding energy of 284.4 eV, sp (C� C) at 285.0 eV, C−O at 286.5 eV, and C�O at 288.0 eV. 43,44 The small amount of C−O and C�O bonds might be due to the oxygen in the air being adsorbed on the surface of GDY, and it was also possible that the oxygen chemically reacted with some of the exposed terminal alkyne bonds. 45 EDS mapping results in Figure 3g showed that higher proportions of Si, O, and C were observed, and small amounts of Fe and Cu were also detected.…”

An H2S‐BMP6 Dual‐Loading System with Regulating Yap/Taz and Jun Pathway for Synergistic Critical Limb Ischemia Salvaging Therapy

“…[39] At present, synergistic therapy has been reported to overcome the shortcomings of monotherapy in diseases. [69] Taking advantage of BMP6, in this study, a novel co-loading nanoplatform called UIO-66-NH 2 @GYY4137@BMP6 was developed using BMP6 recombinant active protein to strengthen the antioxidation and proangiogenic functions. Then we found that UIO-66-NH 2 @GYY4137@BMP6 further magnified the activating ability of Hippo-YAP/TAZ signaling pathway, which plays a vital role in tissue repair and organ regeneration.…”

A Dual Functional Bioinspired Lubricant for Osteoarthritis Treatment and Potential Prevention

“…Lubrication dysfunction of articular cartilage is consequently considered to determine the onset of OA and is followed by synovium inflammation that then promotes the pathological progress of OA. − With respect to the complex and multifactorial characteristics of OA, , therapeutic strategies that only consider lubrication or anti-inflammation are usually ineffective. Additionally, as the global population increasingly ages and as the degradation of articular cartilage is irreversible when OA occurs, the prevention of OA is urgently required, and this may be achieved by a combination of maintaining lubrication and anti-inflammatory conditions. − …”