Abstract:The unique tripeptide structure of green fluorescent
protein (GFP),
a Ser-Tyr-Gly motif, generates the mature chromophore in situ to define
the emission profiles of GFP. Here, we describe the rational design
and discovery of a biomimetic fluorescent emitter, MBP, by mimicking
the key structure of the Ser-Tyr-Gly motif. Through systematically
tailoring the tripeptide, a family of four chromophores were engineered,
while only MBP exhibited bright fluorescence in different fluid solvents
with highly enhanced quan… Show more
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