A Biomimetic Autophagosomes‐Based Nanovaccine Boosts Anticancer Immunity
Liping Qu,
Guanhong Cui,
Yinping Sun
et al.
Abstract:Personalized cancer vaccines based on tumor cell lysates offer promise for cancer immunotherapy yet fail to elicit a robust therapeutic effect due to the weak immunogenicity of tumor antigens. Autophagosomes, obtained from pleural effusions and ascites of cancer patients, have been identified as abundant reservoirs of tumor neoantigens that exhibit heightened immunogenicity. However, their potential as personalized cancer vaccines have been constrained by suboptimal lymphatic‐targeting performances and challen… Show more
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