A biomechanical perspective on walking in patients with peripheral artery disease

Bapat, Ganesh M.; Bashir, Ayisha; Malcolm, Philippe; Johanning, Jason M.; Pipinos, Iraklis I.; Myers, Sara A.

doi:10.1177/1358863x221146207

Cited by 3 publications

(3 citation statements)

References 70 publications

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“… 43 Extensive evidence also supports both the predictive and prognostic value of abnormal gait characteristics for these two conditions. 44 , 45 In contrast, cardiovascular conditions such as CAD appeared to be more closely associated with conventional clinical variables that are more often considered as traditional ASCVD risk factors. This observation, to some degree, aligns with our clinical understanding that unless significant ischaemic symptoms manifest during physical exertion, gait-related changes may not be as apparent as those seen in PAD or HF.…”

Section: Discussionmentioning

confidence: 94%

Association between gait video information and general cardiovascular diseases: a prospective cross-sectional study

Zeng,

Lin,

et al. 2024

European Heart Journal - Digital Health

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Aims Cardiovascular disease (CVD) may not be detected in time with conventional clinical approaches. Abnormal gait patterns have been associated with pathological conditions and can be monitored continuously by gait video. We aim to test the association between non-contact, video-based gait information and general CVD status. Methods and results Individuals undergoing confirmatory CVD evaluation were included in a prospective, cross-sectional study. Gait videos were recorded with a Kinect camera. Gait features were extracted from gait videos to correlate with the composite and individual components of CVD, including coronary artery disease, peripheral artery disease, heart failure, and cerebrovascular events. The incremental value of incorporating gait information with traditional CVD clinical variables was also evaluated. Three hundred fifty-two participants were included in the final analysis [mean (standard deviation) age, 59.4 (9.8) years; 25.3% were female]. Compared with the baseline clinical variable model [area under the receiver operating curve (AUC) 0.717, (0.690–0.743)], the gait feature model demonstrated statistically better performance [AUC 0.753, (0.726–0.780)] in predicting the composite CVD, with further incremental value when incorporated with the clinical variables [AUC 0.764, (0.741–0.786)]. Notably, gait features exhibited varied association with different CVD component conditions, especially for peripheral artery disease [AUC 0.752, (0.728–0.775)] and heart failure [0.733, (0.707–0.758)]. Additional analyses also revealed association of gait information with CVD risk factors and the established CVD risk score. Conclusion We demonstrated the association and predictive value of non-contact, video-based gait information for general CVD status. Further studies for gait video-based daily living CVD monitoring are promising.

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Section: Discussionmentioning

confidence: 94%

Association between gait video information and general cardiovascular diseases: a prospective cross-sectional study

Zeng,

Lin,

et al. 2024

European Heart Journal - Digital Health

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“…IC negatively affects physical activities of daily life 4. Patients with PAD also exhibit functional impairments,4 gait abnormalities5 and muscle strength weakness 6. This leads to decreased health-related quality of life (HRQoL) 7.…”

Section: Introductionmentioning

confidence: 99%

“…1 IC negatively affects physical activities of daily life. 4 Patients with PAD also exhibit functional impairments, 4 gait abnormalities 5…”

Section: Introductionmentioning

confidence: 99%

Short-duration aerobic high-intensity intervals versus moderate exercise training intensity in patients with peripheral artery disease: study protocol for a randomised controlled trial (the Angiof-HIIT Study)

Lanzi,

Pousaz,

Fresa

et al. 2024

BMJ Open

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IntroductionSupervised exercise training is among the first-line therapies for patients with peripheral artery disease (PAD). Current recommendations for exercise include guidance focusing on claudication pain, programme and session duration, and frequency. However, no guidance is offered regarding exercise training intensity. This study aims to compare the effects of 12-week-long supervised walking exercise training (high-intensity interval training (HIIT) vs moderate-intensity exercise (MOD)) in patients with chronic symptomatic PAD.Methods and analysisThis study is a monocentric, interventional, non-blinded randomised controlled trial. 60 patients (30 in each group) will be randomly allocated (by using the random permuted blocks) to 12 weeks (three times a week) of HIIT or MOD. For HIIT, exercise sessions will consist of alternating brief high-intensity (≥85% of the peak heart rate (HRpeak)) periods (≤60 s) of work with periods of passive rest. Patients will be asked to complete 1 and then 2 sets of 5–7 (progressing to 10–15×60 s) walking intervals. For the MOD group, exercise training sessions will consist of an alternation of periods of work performed at moderate intensity (≤76% HRpeak) and periods of passive rest. Interventions will be matched by training load. The primary outcome will be the maximal walking distance. Secondary outcomes will include functional performance, functional capacity, heath-related quality of life, self-perceived walking abilities, physical activity and haemodynamic parameters.Ethics and disseminationThe Angiof-HIIT Study was approved by the Human Research Ethics Committee of the Canton de Vaud (study number: 2022-01752). Written consent is mandatory prior to enrolment and randomisation. The results will be disseminated via national and international scientific meetings, scientific peer-reviewed journals and social media.Trial registration numberNCT05612945.

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Alteration of the ankle brachial index, follow-up of patients at risk of peripheral arterial disease, a descriptive longitudinal study

Cervilla Suárez,

Muñoz Cobos,

García Ruiz

et al. 2024

Current Problems in Cardiology

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A biomechanical perspective on walking in patients with peripheral artery disease

Cited by 3 publications

References 70 publications

Association between gait video information and general cardiovascular diseases: a prospective cross-sectional study

Association between gait video information and general cardiovascular diseases: a prospective cross-sectional study

Short-duration aerobic high-intensity intervals versus moderate exercise training intensity in patients with peripheral artery disease: study protocol for a randomised controlled trial (the Angiof-HIIT Study)

Alteration of the ankle brachial index, follow-up of patients at risk of peripheral arterial disease, a descriptive longitudinal study

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