A biomechanical comparison of kyphoplasty using a balloon bone tamp <i>versus</i> an expandable polymer bone tamp in a deer spine model

Seel, Edward H.; Davies, Evan

doi:10.1302/0301-620x.89b2.17928

Cited by 16 publications

(12 citation statements)

References 40 publications

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“…The present findings, together with those from future in vitro determinations of other cement properties as a function of PLMR, notably, the extent of extravasation of the cement outside the treated VB (a major complication, especially in VP7, 8, 45) in an appropriate animal spine model, such as spines of skeletally mature sheep46 and red deer,47 should inform clinicians in making decisions regarding the manipulation of the PLMR to be used in VP or BKP. It is realized, however, that the significance/implications of these findings can only be established through randomized, prospective, long‐term, multicentered clinical studies in which all variables (in particular, patient characteristics, notably, time between occurrence of compression VB fractures, and performance of VP or BKP), with the exception of the PLMR used, are the same between the study groups.…”

Section: Discussionmentioning

confidence: 72%

Poly(ethylene terephthalate) foams: Correlation between the polymer properties and the foaming process

Sorrentino

Maio

Iannace

2009

J of Applied Polymer Sci

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The foamability of two food-grade, highmolecular-weight poly(ethylene terephthalate)s (PETs) was investigated. Sorption tests were performed to determine the solubility and diffusivity of N 2 and CO 2 in molten polymers at 250 C with a magnetic suspension balance. Pressure-volume-temperature (pVT) data were also measured and used in the context of the Sanchez-Lacombe equation of state to predict the sorption isotherms. The thermal properties, in terms of the glass-transition, melting, and crystallization temperatures, were measured by differential scanning calorimetry analysis on the two high-molecularweight PETs and, for comparison, on a bottle-grade PET. The rheological properties were measured to asses the improvement of the high-molecular-weight PET with respect to the bottle-grade one. Expansion tests were performed on the two high-molecular-weight grades and bottle-grade PETs with a batch foaming process with N 2 , CO 2 , and an 80-20 wt % N 2 -CO 2 mixture used as blowing agents. The whole processing window was explored in terms of temperature, pressure drop rate, and saturation pressure. The results of the foaming experiments were correlated to gas sorption and the thermal and rheological properties of the polymers in the molten state. The results proved the feasibility of foam processing these two highmolecular-weight grades, which gave, when compared to the bottle grade at specific foaming conditions, very low densities and fine morphologies.

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Section: Discussionmentioning

confidence: 72%

Poly(ethylene terephthalate) foams: Correlation between the polymer properties and the foaming process

Sorrentino

Maio

Iannace

2009

J of Applied Polymer Sci

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“…Currently, large animal models, such as sheep, pig, calf, baboon, deer, goat and dog spines have been used to substitute for human spine [1,7,11,12,17,18,21,22]. Before using animal models, it is necessary to study how the parameters of interest differ between species to be aware of the limitations of any particular animal model and to ensure conclusions reached are applicable to human.…”

Section: Discussionmentioning

confidence: 99%

“…Various large animals, such as pig, calf, sheep, baboon, deer, goat and dog spines as models have been used for in vivo and in vitro spinal research [1,7,11,12,17,18,21,22]. In vitro models consisting of cadaveric spine specimens are useful in providing basic understanding of the functioning of the spine.…”

Section: Introductionmentioning

confidence: 99%

Anatomy of large animal spines and its comparison to the human spine: a systematic review

et al. 2009

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Animal models have been commonly used for in vivo and in vitro spinal research. However, the extent to which animal models resemble the human spine has not been well known. We conducted a systematic review to compare the morphometric features of vertebrae between human and animal species, so as to give some suggestions on how to choose an appropriate animal model in spine research. A literature search of all English language peerreviewed publications was conducted using PubMed, OVID, Springer and Elsevier (Science Direct) for the years 1980-2008. Two reviewers extracted data on the anatomy of large animal spines from the identified articles. Each anatomical study of animals had to include at least three vertebral levels. The anatomical data from all animal studies were compared with the existing data of the human spine in the literature. Of the papers retrieved, seven were included in the review. The animals in the studies involved baboon, sheep, porcine, calf and deer. Distinct anatomical differences of vertebrae were found between the human and each large animal spine. In cervical region, spines of the baboon and human are more similar as compared to other animals. In thoracic and lumbar regions, the mean pedicle height of all animals was greater than the human pedicles. There was similar mean pedicle width between animal and the human specimens, except in thoracic segments of sheep. The human spinal canal was wider and deeper in the anteroposterior plane than any of the animals. The mean human vertebral body width and depth were greater than that of the animals except in upper thoracic segments of the deer. However, the mean vertebral body height was lower than that of all animals. This paper provides a comprehensive review to compare vertebrae geometries of experimental animal models to the human vertebrae, and will help for choosing animal model in vivo and in vitro spine research. When the animal selected for spine research, the structural similarities and differences found in the animal studies must be kept in mind.

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“…Therefore, it is necessary to identify suitable animal models as alternatives to the cadaveric human spine. In the past, the spines of various quadrupeds, such as pig, calf, sheep, goat, and dog, have been used as alternative models (Gurwitz et al, 1993;Nagata et al, 1993;Scifert et al, 1999;Baramki et al, 2000;van Dijk et al, 2002;Wilcox et al, 2004;Nuckley et al, 2007;Seel & Davies, 2007).…”

Section: Introductionmentioning

confidence: 99%

Anatomical Characteristics of Deer and Sheep Lumbar Spines: Comparison to the Human Lumbar Spine

et al. 2015

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SUMMARY: Deer and sheep spines are often used as models of the human spine. A prerequisite for the use of animal models is information regarding the interspecies differences in the parameters of general interest. This would clarify the limitations of each animal model and substantiate the applicability of the obtained results to humans. Since sufficient data appear to be currently unavailable, we sought to investigate the feasibility of using deer and sheep as animal models for studies on the human spine. The objective of this study was a thorough comparison of the anatomical parameters of deer and sheep spines with those of the human spine. We employed threedimensional reconstructions of computed tomography images, generated using figure analysis software, which facilitated quantitative analysis of the linear and curvature parameters and the geometric index of the vertebral bodies. Our findings represent a comprehensive database of the anatomical characteristics of the deer and sheep lumbar spines and their comparisons with those of the human lumbar spine. This study provides insight into the similarities and differences in the vertebral geometries between the human spine and the deer and sheep spines. We found that the differences are minimal and that they do not greatly compromise the utility of deer and sheep lumbar spines as models of the human lumbar spine.

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A biomechanical comparison of kyphoplasty using a balloon bone tamp versus an expandable polymer bone tamp in a deer spine model

Cited by 16 publications

References 40 publications

Poly(ethylene terephthalate) foams: Correlation between the polymer properties and the foaming process

Poly(ethylene terephthalate) foams: Correlation between the polymer properties and the foaming process

Anatomy of large animal spines and its comparison to the human spine: a systematic review

Anatomical Characteristics of Deer and Sheep Lumbar Spines: Comparison to the Human Lumbar Spine

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