A biomechanical analysis of venous tissue in its normal and post-phlebitic conditions

McGilvray, Kirk C.; Sarkar, Rajabrata; Nguyen, Khanh P.; Puttlitz, Christian M.

doi:10.1016/j.jbiomech.2010.07.012

Cited by 24 publications

(32 citation statements)

References 35 publications

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“…Regarding the P predictions, considering the Neo-Hookean term did not help either to improve the R 2 coefficients. This means that the circumferential mechanical response is dominated by the fiber behavior, which is consistent with similar results obtained recently on veins for instance [19].…”

Section: Implications On the Orientation And Deposition Of Collagen Fsupporting

confidence: 93%

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Biomechanics of Porcine Renal Arteries and Role of Axial Stretch

Avril¹,

Badel

Gabr

et al. 2013

Journal of Biomechanical Engineering

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It is known that arteries experience significant axial stretches in vivo. Several authors have shown that the axial force needed to maintain an artery at its in vivo axial stretch does not change with transient cyclical pressurization over normal ranges. However, the axial force phenomenon of arteries has never been explained with microstructural considerations. In this paper we propose a simple biomechanical model to relate the specific axial force phenomenon of arteries to the predicted load-dependent average collagen fiber orientation. It is shown that (a) the model correctly predicts the authors' experimentally measured biaxial behavior of pig renal arteries and (b) the model predictions are in agreement with additional experimental results reported in the literature. Finally, we discuss the implications of the model for collagen fiber orientation and deposition in arteries.

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Section: Implications On the Orientation And Deposition Of Collagen Fsupporting

confidence: 93%

“…This is a very interesting phenomenon and the specific biaxial behavior of blood vessels has received much attention by numerous authors [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Biomechanics of Porcine Renal Arteries and Role of Axial Stretch

Avril¹,

Badel

Gabr

et al. 2013

Journal of Biomechanical Engineering

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“…The biaxial samples were firmly sutured (4-0 suture, monofilament, Surgipro II, Syneture, Mansfield, MA) at all four edges [32] and positioned in a custom-built biaxial testing system [33]. Four markers were created by staining the surface of each specimen with black ink in order to form an approximately square-shaped grid (Fig.…”

Section: Methodsmentioning

confidence: 99%

Modeling Degenerative Disk Disease in the Lumbar Spine: A Combined Experimental, Constitutive, and Computational Approach

Ayturk

Gadomski

Schuldt

et al. 2012

Journal of Biomechanical Engineering

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Using a continuum approach for modeling the constitutive mechanical behavior of the intervertebral disk's annulus fibrosus holds the potential for facilitating the correlation of morphology and biomechanics of this clinically important tissue. Implementation of a continuum representation of the disk's tissues into computational models would yield a particularly valuable tool for investigating the effects of degenerative disease. However, to date, relevant efforts in the literature towards this goal have been limited due to the lack of a computationally tractable and implementable constitutive function. In order to address this, annular specimens harvested from a total of 15 healthy and degenerated intervertebral disks were tested under planar biaxial tension. Predictions of a strain energy function, which was previously shown to be unconditionally convex, were fit to the experimental data, and the optimized coefficients were used to modify a previously validated finite element model of the L4/L5 functional spinal unit. Optimization of material coefficients based on experimental results indicated increases in the micro-level orientation dispersion of the collagen fibers and the mechanical nonlinearity of these fibers due to degeneration. On the other hand, the finite element model predicted a progressive increase in the stress generation in annulus fibrosus due to stepwise degeneration of initially the nucleus and then the entire disk. Range of motion was predicted to initially increase with the degeneration of the nucleus and then decrease with the degeneration of the annulus in all rotational loading directions, except for axial rotation. Overall, degeneration was observed to specifically impact the functional effectiveness of the collagen fiber network of the annulus, leading to changes in the biomechanical behavior at both the tissue level and the motion-segment level.

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“…In contrast to the work done on arteries, there have been only a few papers describing the multi-axial mechanical response of veins within the framework of nonlinear elasticity (Desch and Weizsäcker, 2007;Cacho et al, 2007;McGilvray et al, 2010;Sokolis, 2013;Zhao et al, 2007). Probably, the most comprehensive study of mechanical properties of saphenous veins has been provided by Donovan et al (1990).…”

Section: Introductionmentioning

confidence: 99%

Constitutive modeling of human saphenous veins at overloading pressures

Vesely¹,

Horny²,

Chlup³

et al. 2015

Journal of the Mechanical Behavior of Biomedical Materials

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In the present study, inflation tests with free axial extension of 15 human vena saphena magna were conducted ex vivo to obtain data suitable for multi-axial constitutive modeling at overloading conditions (pressures up to approximately 15kPa). Subsequently the data were fitted with a hyperelastic, nonlinear and anisotropic constitutive model based on the theory of the closed thick-walled tube. It was observed that initial highly deformable behavior (up to approximately 2.5kPa) in the pressure-circumferential stretch response is followed by progressive large strain stiffening. Contrary to that, samples were much stiffer in longitudinal direction, where the observed stretches were in the range 0.98-1.03 during the entire pressurization in most cases. The effect of possible residual stress was evaluated in a simulation of the intramural stress distribution with the opening angle prescribed to 0°, 10°, 20°, 30°, 40°, and 50°. The result suggests that the optimal opening angle making the stress distribution through the wall thickness uniform is about 40°. The material parameters presented here are suitable for use in mechanobiological simulations describing the adaptation of the autologous vein wall after bypass surgery.

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A biomechanical analysis of venous tissue in its normal and post-phlebitic conditions

Cited by 24 publications

References 35 publications

Biomechanics of Porcine Renal Arteries and Role of Axial Stretch

Biomechanics of Porcine Renal Arteries and Role of Axial Stretch

Modeling Degenerative Disk Disease in the Lumbar Spine: A Combined Experimental, Constitutive, and Computational Approach

Constitutive modeling of human saphenous veins at overloading pressures

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