A biomarker-responsive nanoprobe for detecting hepatic ischemia-reperfusion injury<i>via</i>optoacoustic/NIR-II fluorescence imaging

Zeng, Zhi; Chen, Junjie; Sun, Linhui; Zeng, Fang; Wu, Shuizhu

doi:10.1039/d2cc06031k

Cited by 4 publications

(2 citation statements)

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“…It is employed for the detection and imaging of liver ischemiareperfusion injury within the 900−1300 nm range. 154 Additionally, the group has developed another novel H 2 O 2 probe, PEG 3 -HC-PB, for the detection of acute kidney injury (AKI), a serious health threat associated with high morbidity and mortality rates and potential long-term complications. 155 The design of this probe involves the introduction of three hydrophilic PEG 3 groups to shield the responsive group HC-PB, ensuring water solubility and preventing protein binding.…”

Section: In Vivomentioning

confidence: 99%

“…This probe utilizes bovine serum albumin (BSA) as a substrate, encapsulating the molecular probe BX-BOH to ensure excellent water dispersibility and biocompatibility. It is employed for the detection and imaging of liver ischemia-reperfusion injury within the 900–1300 nm range . Additionally, the group has developed another novel H 2 O 2 probe, PEG 3 -HC-PB, for the detection of acute kidney injury (AKI), a serious health threat associated with high morbidity and mortality rates and potential long-term complications .…”

Section: Application Of Nir-ii Fluorescence Probes In Quantitative An...mentioning

confidence: 99%

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NIR-II Fluorescence Imaging for In Vivo Quantitative Analysis

Chen,

Wang,

Zhu

et al. 2024

ACS Appl. Mater. Interfaces

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In vivo real-time qualitative and quantitative analysis is essential for the diagnosis and treatment of diseases such as tumors. Near-infrared-II (NIR-II, 1000−1700 nm) bioimaging is an emerging visualization modality based on fluorescent materials. The advantages of NIR-II region fluorescent materials in terms of reduced photon scattering and low tissue autofluorescence enable NIR-II bioimaging with high resolution and increasing depth of tissue penetration, and thus have great potential for in vivo qualitative and quantitative analysis. In this review, we first summarize recent advances in NIR-II imaging, including fluorescent probe selection, quantitative analysis strategies, and imaging. Then, we describe in detail representative applications to illustrate how NIR-II fluorescence imaging has become an important tool for in vivo quantitative analysis. Finally, we describe the future possibilities and challenges of NIR-II fluorescence imaging.

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Section: In Vivomentioning

confidence: 99%

Section: Application Of Nir-ii Fluorescence Probes In Quantitative An...mentioning

confidence: 99%

NIR-II Fluorescence Imaging for In Vivo Quantitative Analysis

Chen,

Wang,

Zhu

et al. 2024

ACS Appl. Mater. Interfaces

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A multifunctional nanoaggregate‐based system for detection of rheumatoid arthritis via Optoacoustic/NIR‐II fluorescent imaging and therapy via inhibiting JAK‐STAT/NF‐κB/NLRP3 pathways

Chen,

She

et al. 2023

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Rheumatoid arthritis (RA) is a debilitating autoimmune disease that causes chronic pain and serious complications, presenting a significant challenge to treat. Promising approaches for treating RA involve signaling pathways modulation and targeted therapy. To this end, a multifunctional nanosystem, TPC‐U@HAT, has been designed for RA therapy, featuring multitargeting, dual‐stimuli response, and on‐demand drug release capabilities. TPC‐U@HAT is composed of a probe/prodrug TPC, a JAK1 kinase inhibitor upadacitinib, and the drug carrier HAT. TPC is composed of an aggregation‐induced emission (AIE)‐active NIR‐II chromophore TPY and an NF‐κB/NLRP3 inhibitor caffeic acid phenethyl ester (CAPE), connected via boronic ester bond which serves as the reactive‐oxygen‐species‐responsive linker. The carrier, HAT, is created by grafting bone‐targeting alendronate and hydrophobic tocopheryl succinate onto hyaluronic acid chains, which can encapsulate TPC and upadacitinib to form TPC‐U@HAT. Upon intravenous injection into mice, TPC‐U@HAT accumulates at inflamed lesions of RA through both active and passive targeting, and the overexpressed hyaluronidase and H2O2 therein cleave the hyaluronic acid polymer chains and boronate bonds, respectively. This generates an AIE‐active chromophore for detection and therapeutic evaluation of RA via both optoacoustic imaging and NIR‐II fluorescent imaging and concomitantly releases CAPE and upadacitinib to exert efficacious therapy by inhibiting NF‐κB/NLRP3 and JAK‐STAT pathways.

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Advances and perspectives in fluorescent probes for imaging hepatopathy-related biomarkers

Quan,

Song,

Zhang

et al. 2023

Coordination Chemistry Reviews

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A biomarker-responsive nanoprobe for detecting hepatic ischemia-reperfusion injuryviaoptoacoustic/NIR-II fluorescence imaging

Abstract: Hepatic ischemia-reperfusion injury (HIRI) is a primary cause of liver damage and a common major complication in liver surgeries as well as is the key cause for early or late...

Cited by 4 publications

References 25 publications

NIR-II Fluorescence Imaging for In Vivo Quantitative Analysis

NIR-II Fluorescence Imaging for In Vivo Quantitative Analysis

A multifunctional nanoaggregate‐based system for detection of rheumatoid arthritis via Optoacoustic/NIR‐II fluorescent imaging and therapy via inhibiting JAK‐STAT/NF‐κB/NLRP3 pathways

Advances and perspectives in fluorescent probes for imaging hepatopathy-related biomarkers

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