A biologically active diphenyl ether from the green algaCladophora fascicularis

Kuniyoshi, Masayuki; Yamada, Kaoru; Higa, Tatsuo

doi:10.1007/bf01966182

Cited by 92 publications

(60 citation statements)

References 4 publications

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“…Their structural analogs, including methoxylated (MeO-) and hydroxylated (OH-) PBDEs, have also been widely detected in environmental substrates, such as algae (Asplund et al, 2001;Kuniyoshi et al, 1985;Malmvärn et al, 2005Malmvärn et al, , 2008, fish (Valters et al, 2005;Zhang et al, 2010), marine animals (Fu et al, 1995;Kelly et al, 2008;Liu et al, 2012), sediments (Bradley et al, 2011;Zhang et al, 2012) and even humans (Hovander et al, 2002;Lacorte and Ikonomou, 2009;Stapleton et al, 2009;Wan et al, 2010a). Some species of MeO/OH-BDEs have shown equivalent toxic effects to PBDEs , so identifying their source has attracted increasing interest.…”

Section: Introductionmentioning

confidence: 99%

“…Since the 1980s, these compounds have been widely detected as the dominant congeners of oxygenated PBDEs in sponges (Bowden et al, 2000;Carté and Faulkner, 1981;Fu et al, 1995;Handayani et al, 1997), algae (Asplund et al, 2001;Kuniyoshi et al, 1985), and marine animals at high trophic levels (Asplund et al, 2001;Verreault et al, 2005). On the basis of early marine pharmacological research (Faulkner et al, 1994), marine sponges are commonly considered as one of the main producers of these natural compounds.…”

Section: Introductionmentioning

confidence: 99%

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Major sources of MeO/OH-BDEs in the East China Sea elucidated from their records and phytoplankton biomarkers

Fan

Huh

Lan

et al. 2014

Environmental Pollution

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Major sources of MeO/OH-BDEs in the East China Sea elucidated from their records and phytoplankton biomarkers

Fan

Huh

Lan

et al. 2014

Environmental Pollution

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“…Methoxylated PBDEs in wild marine organisms have been suggested to originate mainly from natural products such as formation in alage or via hydroxylation followed by methylation by microorganisms in sediment and organisms [18][19][20][21]. Although the possibility of MeO-PBDEs formation via methylation of their hydroxylated homologues cannot be ruled out [14,21], they have never been found as originating directly from PBDE metabolism in laboratory experiments [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Gastrointestinal absorption, metabolic debromination, and hydroxylation of three commercial polybrominated diphenyl ether mixtures by common carp

Zeng

Luo

Chen

et al. 2012

Enviro Toxic and Chemistry

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Abstract-The gastrointestinal absorption, metabolic debromination, and hydroxylation of three commercial brominated diphenyl ether (BDE) mixtures were separately studied in juvenile common carp. The absorption rate of penta-BDE was higher than that of octa-and deca-BDE, likely because of the lower molecular volumes of its major congeners. However, no significantly positive relationships were found between the number of bromine atoms and the absorption rate, especially for congeners with a bromine atom number larger than six. The major congeners in fish carcass were, respectively, BDE-47 and BDE-100 in the penta-BDE exposure; BDE-154, -155, -149, and BDE-153 in the octa-BDE exposure; and in the deca-BDE exposure. Congeners with at least one meta-or para-doubly flanked bromine atom easily undergo metabolic debromination in fish. None of the targeted MeOpolybrominated diphenyl ether (PBDE) congeners were detected in serum samples, implying that the methylation of OH-PBDE is not likely occurring in fish. Eleven OH-PBDEs and several unidentified OH-PBDE congeners were found in penta-BDE-exposed fish. The similar level among three mono-OH-BDE47 congeners suggested that the position of OH in the phenyl ring is not selective. The hydroxylation is not a significant metabolic pathway compared with debromination. No OH-PBDE congeners were found in the serum samples from deca-BDE-exposed fish, which may attributable to the low level of PBDE precursors in fish. Environ. Toxicol. Chem.

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“…[25] Previous studies have reported that 6-OH-BDE47, 2 0 -OH-BDE68, 6-MeO-BDE47 and 2 0 -MeO-BDE68 are the dominant MeO-PBDE and OH-PBDE congeners in algae. [6,7] Therefore, as previously proposed, [19,25,26] phytoplankton are likely to be more important producers of MeO-PBDEs and OH-PBDEs compared with sponges and their symbiotic cyanobacteria, [49] which are mainly located in tropical oceans. Fig.…”

Section: Resultsmentioning

confidence: 90%

Methoxylated and hydroxylated polybrominated diphenyl ethers in surface sediments from the southern Yellow Sea: spatial distribution and potential producers

Fan¹,

Lan²,

Wang³

et al. 2015

Environ. Chem.

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Environmental context. Methoxylated and hydroxylated polybrominated diphenyl ethers are of increasing concern owing to their global distribution and potential ecological risks. We investigated the spatial distribution and sources of these brominated compounds in surface sediments from the southern Yellow Sea, China. The results suggest that marine phytoplankton may be the potential producers of these compounds, thereby providing new insights into their occurrence and provenance in marine environments.Abstract. Methoxylated polybrominated diphenyl ethers (MeO-PBDEs) and hydroxylated polybrominated diphenyl ethers (OH-PBDEs) have recently caused worldwide concern; however, there have been very limited studies on their presence in marine sediments. In the present study, MeO-PBDEs, OH-PBDEs and phytoplankton biomarkers were determined in surface sediments from the southern Yellow Sea. MeO-PBDEs and OH-PBDEs are ubiquitous in southern Yellow Sea sediments, with total contents ranging from 43.0 to 571.4 pg g À1 dry weight. High contents of these compounds mainly concentrated in the central southern Yellow Sea basin, and their spatial distributions generally presented a seaward-increasing trend. By comparing with total organic carbon and terrestrial organic matter contributions in sediments, these compounds were inferred to originate mainly from marine production rather than from terrigenous inputs. Statistical analysis shows that there are significant correlations between MeO-PBDEs, OH-PBDEs and phytoplankton biomarkers, indicating that MeO-PBDEs and OH-PBDEs are mainly natural compounds, and the phytoplankton are likely to be their potential producers in the southern Yellow Sea, especially for dinosterol.

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A biologically active diphenyl ether from the green algaCladophora fascicularis

Cited by 92 publications

References 4 publications

Major sources of MeO/OH-BDEs in the East China Sea elucidated from their records and phytoplankton biomarkers

Major sources of MeO/OH-BDEs in the East China Sea elucidated from their records and phytoplankton biomarkers

Gastrointestinal absorption, metabolic debromination, and hydroxylation of three commercial polybrominated diphenyl ether mixtures by common carp

Methoxylated and hydroxylated polybrominated diphenyl ethers in surface sediments from the southern Yellow Sea: spatial distribution and potential producers

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