A biologically active constituent of withania somnifera (ashwagandha) with antistress activity

Kaur, Parvinder; Mathur, Sheenu; Sharma, Meenakshi; Tiwari, Manisha; Srivastava, Kamna; Chandra, Ramesh

doi:10.1007/bf02864860

Cited by 36 publications

(15 citation statements)

References 7 publications

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“…(Table 1). Numerous preclinical studies have shown there wide range of pharmacological activities and their safety in usage (Calderon et al, 2011;Vladimir et al, 2014;Khalil et al, 2017). The presence of these common components in many of these anti-stress herbs indicates towards their most probable role in managing the stress.…”

Section: Introductionmentioning

confidence: 99%

Molecular-Docking Study of Anti-Stress Natural Compounds Against GABAa Receptor Portends the Novel Approach to Stress Treatment

2018

J App Pharm Sci

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During stress our body responds by activating the nervous system and hormones. The stress response is conveyed by hypothalamic-pituitary-adrenal axis and is responsible for neuroendocrine adaptation of stress response. Hypothalamic-pituitary-adrenal activity is governed by corticotrophin releasing hormone neurons. Increased production of corticotrophin releasing hormone is associated with various stress related metabolic and neurological disorders. The activity of CRH neurons is largely regulated by Gamma-aminobutyric acid (GABA) and is controlled by GABAergic inhibition. To lower down the effect of stress, various synthetic drugs are used which target GABAa receptor and activates GABAa activity, producing calming effects but also comes along with various side effects. Hence anti-stress herbs is used as an alternative therapy which helps improving the adrenal system has no side effects and are safe for long term use. Method: Our current study is an attempt to analyze the possible mechanism of action of some compounds commonly present in extracts of different anti-stress herbs by using AutoDockVina. Result: As a result of our docking studies with GABAa protein, we have observed that some herbal compounds such as Rosmarinic Acid and Kaempferol are showing comparable binding affinity towards GABAa receptor, like Lorazepam. Few other compounds sharing common binding site like Lorazepam, indicates that their mechanism of action may also be through activating GABAa receptor.

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Section: Introductionmentioning

confidence: 99%

Molecular-Docking Study of Anti-Stress Natural Compounds Against GABAa Receptor Portends the Novel Approach to Stress Treatment

2018

J App Pharm Sci

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“…Colonic temperature recovery, reduced stress, enhanced open field behavior, emotional stability with a significant enhancement in the functional sensitivity of 5-HT2 receptors in the brain and a reciprocal sub-sensitivity of the 5-HT1A receptors (Kaur et al 2001;Tripathi et al 1998) Anti-ulcer activity W. somnifera (methanolic extract)…”

Section: Experimental Design Resultsmentioning

confidence: 97%

Recent advances in elucidating the biological properties of Withania somnifera and its potential role in health benefits

et al. 2011

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Withania somnifera (L.) Dunal (Solanaceae), also known as ashwagandha, is an important medicinal plant that is widely used as a home remedy for several diseases in the Indian subcontinent and other parts of the world. W. somnifera is a dietary supplement composed of various nutrients, polyphenols and alkaloids that have free radical scavenging capacity, as well as other chemical constituents that possess anti-inflammatory, antitumor, anti-stress, antioxidant, immunomodulatory, and rejuvenating properties. The mechanism of action for these properties are not fully understood. W. somnifera also appears to influence the endocrine, cardiopulmonary and central nervous systems. Toxicity studies reveal that W. somnifera can be used without side effects. The findings presented in this review are very encouraging and indicate that this herb should be studied more extensively to confirm these results and to reveal other potential therapeutic effects.

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“… anti-inflammatory [61]  Anti-influenza Properties [62]  anti-stress activity [63]  Antibacterial activity against Gram-positive isolates from pus samples [64]…”

Section: Rootmentioning

confidence: 99%

A Pharmacological Review of Siddha Classical Preparations for the Management of COVID-19 at TPEC COVID Care Centre, Vellore

Thillaivanan

Samraj

Susikannamma

et al. 2021

JPRI

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Despite the threat of coronavirus infection, the Siddha system of medicine, India's traditional medicine, plays an important role in southern India, particularly in Tamilnadu. It contributed considerably not only in the first wave of Covid-19, but also in the second wave. The Government of Tamilnadu developed Siddha COVID-19 treatment centers for asymptomatic, mild, and moderate COVID-19 positive patients in 2020. The TPEC COVID Care Centre initiated at Vellore also one of the Centers that can be managed by Siddha medicines and Siddhar’s Yogam. As of July 14, 2021, about 4525 COVID positive patients had been treated with Siddha integrated treatment at Vellore alone in the first and second waves. Kaba Sura Kudineer, Thalisathy Vadagam, Amukkara Chooranam Mathirai, Bramanandha Bairavam Mathirai, and Adathodai Manapagu are indeed the five Siddha classical preparations used to manage the symptoms of COVID-19 positive patients at TPEC COVID Care Centre in Vellore. This Siddha medical practice is effective in conditions of symptoms and helps in the reduction of clinical outcomes. A pilot study at the same site confirmed the Siddha classical preparation's safety and effectiveness. A feedback analysis study performed at the same center also revealed that the above-mentioned Siddha classical preparations are beneficial in symptomatic treatment without causing any side effects. The medicines utilized in this study are typically proposed in other COVID care centers also in Tamilnadu. This review attempted to analyze the preclinical and clinical efficacy of Siddha Classical medicines used at that Centre for the management of COVID-19.

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A biologically active constituent of withania somnifera (ashwagandha) with antistress activity

Cited by 36 publications

References 7 publications

Molecular-Docking Study of Anti-Stress Natural Compounds Against GABAa Receptor Portends the Novel Approach to Stress Treatment

Molecular-Docking Study of Anti-Stress Natural Compounds Against GABAa Receptor Portends the Novel Approach to Stress Treatment

Recent advances in elucidating the biological properties of Withania somnifera and its potential role in health benefits

A Pharmacological Review of Siddha Classical Preparations for the Management of COVID-19 at TPEC COVID Care Centre, Vellore

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