A bioinspired fluorescent probe based on metal–organic frameworks to selectively enrich and detect amyloid-β peptide

Wang, Ziyuan; Jiao, Yi; Ding, Qingyuan; Ye, Song; Ma, Qi; Ren, Haixia; Lü, Kun; Jia, Shiru; Cui, Jiandong

doi:10.1016/j.cej.2023.144124

Cited by 5 publications

(2 citation statements)

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“…Research on the detection of AβO has taken diverse approaches, such as conventional [ 11 , 12 , 13 , 14 ], optical [ 15 , 16 , 17 , 18 ], electrochemical [ 19 , 20 , 21 ], and electroluminescent methods [ 22 , 23 , 24 , 25 ], and quartz crystal microbalance [ 26 , 27 , 28 ]. Among these, conventional detection methods utilize magnetic resonance imaging (MRI) [ 13 , 14 , 29 ], near-infrared fluorescent (NIRF) [ 16 , 30 , 31 ], and positron emission tomography (PET) [ 11 , 12 , 32 , 33 ], which are time-consuming, have low spatial resolution [ 34 ], and are also expensive as well as cause side effects such as vomiting, flushing, itching, headache, and nausea [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Research on the detection of AβO has taken diverse approaches, such as conventional [11][12][13][14], optical [15][16][17][18], electrochemical [19][20][21], and electroluminescent methods [22][23][24][25], and quartz crystal microbalance [26][27][28]. Among these, conventional detection methods utilize magnetic resonance imaging (MRI) [13,14,29], near-infrared fluorescent (NIRF) Research on the detection of AβO has taken diverse approaches, such as conventional [11][12][13][14], optical [15][16][17][18], electrochemical [19][20][21], and electroluminescent methods [22][23][24][25], and quartz crystal microbalance [26][27][28]. Among these, conventional detection methods utilize magnetic resonance imaging (MRI) [13,14,29], near-infrared fluorescent (NIRF) [16,30,31], and positron emission tomogr...…”

Section: Introductionmentioning

confidence: 99%

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SAM-Support-Based Electrochemical Sensor for Aβ Biomarker Detection of Alzheimer’s Disease

Kim

Cho

2023

Biosensors

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Alzheimer’s disease has taken the spotlight as a neurodegenerative disease which has caused crucial issues to both society and the economy. Specifically, aging populations in developed countries face an increasingly serious problem due to the increasing budget for patient care and an inadequate labor force, and therefore a solution is urgently needed. Recently, diverse techniques for the detection of Alzheimer’s biomarkers have been researched and developed to support early diagnosis and treatment. Among them, electrochemical biosensors and electrode modification proved their effectiveness in the detection of the Aβ biomarker at appropriately low concentrations for practice and point-of-care application. This review discusses the production and detection ability of amyloid beta, an Alzheimer’s biomarker, by electrochemical biosensors with SAM support for antibody conjugation. In addition, future perspectives on SAM for the improvement of electrochemical biosensors are also proposed and discussed.

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