A bioinspired 4D printed hydrogel capsule for smart controlled drug release

Zu, Shuo; Wang, Z.; Zhang, S.; Guo, Yuna; Chen, C.; Zhang, Q.; Wang, Z.; Liu, T.; Liu, Q.; Zhang, Z.

doi:10.1016/j.mtchem.2022.100789

Cited by 29 publications

(25 citation statements)

References 59 publications

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“…Recently, Zu et al developed a poly(N-isopropylacrylamide) (PNIPAM)-based capsule shell for smart controlled drug release. The presence of PNIPAM introduced temperature responsiveness; thus, the controlled drug release can be attributed to the modification of the internal pore size, achieved by the variation of the temperature above or below the lower critical solution temperature (LCST) [ 72 ]. However, hydrogels show some limitations in terms of mechanical strength, stability, and manipulation possibilities.…”

Section: Three-dimensional and Four-dimensional Printingmentioning

confidence: 99%

3D and 4D Printing in the Fight against Breast Cancer

2022

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Breast cancer is the second most common cancer worldwide, characterized by a high incidence and mortality rate. Despite the advances achieved in cancer management, improvements in the quality of life of breast cancer survivors are urgent. Moreover, considering the heterogeneity that characterizes tumors and patients, focusing on individuality is fundamental. In this context, 3D printing (3DP) and 4D printing (4DP) techniques allow for a patient-centered approach. At present, 3DP applications against breast cancer are focused on three main aspects: treatment, tissue regeneration, and recovery of the physical appearance. Scaffolds, drug-loaded implants, and prosthetics have been successfully manufactured; however, some challenges must be overcome to shift to clinical practice. The introduction of the fourth dimension has led to an increase in the degree of complexity and customization possibilities. However, 4DP is still in the early stages; thus, research is needed to prove its feasibility in healthcare applications. This review article provides an overview of current approaches for breast cancer management, including standard treatments and breast reconstruction strategies. The benefits and limitations of 3DP and 4DP technologies are discussed, as well as their application in the fight against breast cancer. Future perspectives and challenges are outlined to encourage and promote AM technologies in real-world practice.

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Section: Three-dimensional and Four-dimensional Printingmentioning

confidence: 99%

3D and 4D Printing in the Fight against Breast Cancer

2022

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“…Wang et al [ 148 ] fabricated methotrexate loaded pluronic diacrylate macromer and alginate-based hybrid hydrogel system (in the shape of square mesh) by DIW-4D printing using UV-curing. The hydrogels were demonstrated for aqueous calcium chloride (1% w / v ) responsiveness (folding), which released around 80% of the drug over 12 h with a fast release profile for the first 6 h. On the other hand, Zhao et al [ 149 ] fabricated heparin-loaded gelatine methacryloyl hydrogels (in the shape of strips on flat sheets) by DIW 4D printing and UV-curing, which folded into a tube-like structure when exposed to water and released around 70% of the drug over 30 h with a fast release profile for the first 8 h. Lately, Zu and co-workers [ 150 ] developed a core–shell capsule delivery system ( Figure 10 a) comprising a brilliant blue core and PNIPAM hydrogel shell by DIW 4D printing and UV-curing. These capsules are responsive to temperature and shrink to release almost 100% of the drug in 48 h with a fast release profile for the first 15 h. In a separate study, Melocchi et al [ 151 ] fabricated caffeine-loaded I, U, and helix-shaped PVA hydrogel constructs by FDM 4D printing extruded at 180 °C.…”

Section: Emerging 4d Printed Hydrogels For Drug Deliverymentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

4D Printing of Hydrogels: Innovation in Material Design and Emerging Smart Systems for Drug Delivery

et al. 2022

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Advancements in the material design of smart hydrogels have transformed the way therapeutic agents are encapsulated and released in biological environments. On the other hand, the expeditious development of 3D printing technologies has revolutionized the fabrication of hydrogel systems for biomedical applications. By combining these two aspects, 4D printing (i.e., 3D printing of smart hydrogels) has emerged as a new promising platform for the development of novel controlled drug delivery systems that can adapt and mimic natural physio-mechanical changes over time. This allows printed objects to transform from static to dynamic in response to various physiological and chemical interactions, meeting the needs of the healthcare industry. In this review, we provide an overview of innovation in material design for smart hydrogel systems, current technical approaches toward 4D printing, and emerging 4D printed novel structures for drug delivery applications. Finally, we discuss the existing challenges in 4D printing hydrogels for drug delivery and their prospects.

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“…The hydrogel-based organs produced by Kang et al [43] and Cui et al [44] are prime examples of such structures. Zu et al [45] have created a hydrogel capsule delivering drugs when reaching specific stimuli. The 4D printing actuation can be used for bone repairing, as shown by You et al [46] Adding living cells in the hygromorphs can also help to obtain even greater multi-functionality in the structure.…”

Section: Applicationsmentioning

confidence: 99%

“…Zu et al. [ 45 ] have created a hydrogel capsule delivering drugs when reaching specific stimuli. The 4D printing actuation can be used for bone repairing, as shown by You et al.…”

Section: Introductionmentioning

confidence: 99%

The Design of 4D‐Printed Hygromorphs: State‐of‐the‐Art and Future Challenges

Kergariou

Demoly

Perriman

et al. 2022

Adv Funct Materials

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In recent years, 4D printing has allowed the rapid development of new concepts of multifunctional/adaptive structures. The 4D printing technology makes it possible to generate new shapes and/or property-changing capabilities by combining smart materials, multiphysics stimuli, and additive manufacturing. Hygromorphs constitute a specific class of new smart materials where their properties and morphing capabilities are dependent on the surrounding humidity, which drives actuation. Although multiple efforts have been made to fabricate hygromorph demonstrators, a comprehensive design process to produce hygromorphs by multiple 4D printing techniques is not yet available. The broad aim of this review and concept paper is to i) highlight existing scientific and technology gaps in the field of 4D-printed hygromorphs, ii) identify tools existing in other research fields for filling those gaps, and iii) discuss a series of guidelines for tackling future challenges and opportunities to develop 4D-printed composite hygromorph materials and related manufacturing processes. Accordingly, this review describes the materials and additive manufacturing techniques used for hygromorph composite fabrication. Moreover, the relevant parameters that control actuation, the models selection and performance, the design methods and the actuation measurements for customized 4D-printed hygromorph materials, are discussed.

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A bioinspired 4D printed hydrogel capsule for smart controlled drug release

Cited by 29 publications

References 59 publications

3D and 4D Printing in the Fight against Breast Cancer

3D and 4D Printing in the Fight against Breast Cancer

4D Printing of Hydrogels: Innovation in Material Design and Emerging Smart Systems for Drug Delivery

The Design of 4D‐Printed Hygromorphs: State‐of‐the‐Art and Future Challenges

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