A bioinformatics view of zinc enzymes

Andreini, Claudia; Bertini, Ivano

doi:10.1016/j.jinorgbio.2011.11.020

Cited by 180 publications

(121 citation statements)

References 50 publications

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“…Zinc binding sites in proteins are typically formed by His, Cys, Glu, and Asp residues (33). A previous analysis in the PDB database found 6200 zinc-containing sites (38). From this list, 4 we have found 12 wild-type entries, representing 6 proteins that are observed with Gln as a zinc ligand, none of which are peptidoglycan peptidases (Table 4).…”

Section: Discussionmentioning

confidence: 94%

Helical Shape of Helicobacter pylori Requires an Atypical Glutamine as a Zinc Ligand in the Carboxypeptidase Csd4

Chan

Blair

Liu

et al. 2015

Journal of Biological Chemistry

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Section: Discussionmentioning

confidence: 94%

Helical Shape of Helicobacter pylori Requires an Atypical Glutamine as a Zinc Ligand in the Carboxypeptidase Csd4

Chan

Blair

Liu

et al. 2015

Journal of Biological Chemistry

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“…In catalytic functions, zinc can activate substrates in enzymes by stabilizing negative charges, because of its strong Lewis acid property (264). After the first identification of zinc in erythrocyte carbonic anhydrase as a zinc-dependent enzyme (205), the presence of zinc has been recognized in many enzymes in all six classes defined in the Enzyme Commission (EC) system (5,420,421) (TABLE 1).…”

Section: B Zinc Biochemistrymentioning

confidence: 99%

The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism

Kambe

Tsuji

Hashimoto

et al. 2015

Physiological Reviews

838

797

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Zinc is involved in a variety of biological processes, as a structural, catalytic, and intracellular and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the whole body, tissue, cellular, and subcellular levels by a number of proteins, with zinc transporters being particularly important. In metazoan, two zinc transporter families, Zn transporters (ZnT) and Zrt-, Irt-related proteins (ZIP) function in zinc mobilization of influx, efflux, and compartmentalization/ sequestration across biological membranes. During the last two decades, significant progress has been made in understanding the molecular properties, expression, regulation, and cellular and physiological roles of ZnT and ZIP transporters, which underpin the multifarious functions of zinc. Moreover, growing evidence indicates that malfunctioning zinc homeostasis due to zinc transporter dysfunction results in the onset and progression of a variety of diseases. This review summarizes current progress in our understanding of each ZnT and ZIP transporter from the perspective of zinc physiology and pathogenesis, discussing challenging issues in their structure and zinc transport mechanisms.

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“…Zinc has structural, functional, and combined roles in numerous proteins including approximately 2,700 enzymes (Andreini and Bertini 2012) such as hydrolases, transferases, oxido-reductases, ligases, isomerases and lyases. Structurally, zinc is present in different protein domains.…”

Section: Biological Functions Of Zincmentioning

confidence: 99%

Zinc and the aging brain

Nuttall

Oteiza

2013

Genes Nutr

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Alterations in trace element homeostasis could be involved in the pathology of dementia, and in particular of Alzheimer's disease (AD). Zinc is a structural or functional component of many proteins, being involved in numerous and relevant physiological functions. Zinc homeostasis is affected in the elderly, and current evidence points to alterations in the cellular and systemic distribution of zinc in AD. Although the association of zinc and other metals with AD pathology remains unclear, therapeutic approaches designed to restore trace element homeostasis are being tested in clinical trials. Not only could zinc supplementation potentially benefit individuals with AD, but zinc supplementation also improves glycemic control in the elderly suffering from diabetes mellitus. However, the findings that select genetic polymorphisms may alter an individual's zinc intake requirements should be taken into consideration when planning zinc supplementation. This review will focus on current knowledge regarding pathological and protective mechanisms involving brain zinc in AD to highlight areas where future research may enable development of new and improved therapies.

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A bioinformatics view of zinc enzymes

Cited by 180 publications

References 50 publications

Helical Shape of Helicobacter pylori Requires an Atypical Glutamine as a Zinc Ligand in the Carboxypeptidase Csd4

Helical Shape of Helicobacter pylori Requires an Atypical Glutamine as a Zinc Ligand in the Carboxypeptidase Csd4

The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism

Zinc and the aging brain

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