A bioinformatics analysis, pre-clinical and clinical conception of autophagy in pancreatic cancer: Complexity and simplicity in crosstalk

Ashrafizadeh, Milad; Zhang, Wei; Zou, Rongjun; Sethi, Gautam; Klionsky, Daniel J.; Zhang, Xianbin

doi:10.1016/j.phrs.2023.106822

Cited by 46 publications

(9 citation statements)

References 201 publications

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“…Chemotherapy is still the first-line therapy for cancer treatment. Chemoresistance is related to a variety of factors, including cell proliferation, apoptosis, DNA damage and epithelial-mesenchymal transition [ 123 , 124 ]. A number of studies have shown that lipid droplets and phospholipids play an important role in tumor chemotherapy resistance in breast cancer and other tumors.…”

Section: Discussionmentioning

confidence: 99%

Reprogramming of lipid metabolism in the tumor microenvironment: a strategy for tumor immunotherapy

Wu,

Pu,

Wang

et al. 2024

Lipids Health Dis

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Lipid metabolism in cancer cells has garnered increasing attention in recent decades. Cancer cells thrive in hypoxic conditions, nutrient deficiency, and oxidative stress and cannot be separated from alterations in lipid metabolism. Therefore, cancer cells exhibit increased lipid metabolism, lipid uptake, lipogenesis and storage to adapt to a progressively challenging environment, which contribute to their rapid growth. Lipids aid cancer cell activation. Cancer cells absorb lipids with the help of transporter and translocase proteins to obtain energy. Abnormal levels of a series of lipid synthases contribute to the over-accumulation of lipids in the tumor microenvironment (TME). Lipid reprogramming plays an essential role in the TME. Lipids are closely linked to several immune cells and their phenotypic transformation. The reprogramming of tumor lipid metabolism further promotes immunosuppression, which leads to immune escape. This event significantly affects the progression, treatment, recurrence, and metastasis of cancer. Therefore, the present review describes alterations in the lipid metabolism of immune cells in the TME and examines the connection between lipid metabolism and immunotherapy.

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Section: Discussionmentioning

confidence: 99%

Reprogramming of lipid metabolism in the tumor microenvironment: a strategy for tumor immunotherapy

Wu,

Pu,

Wang

et al. 2024

Lipids Health Dis

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“…Furthermore, macrophage-mimetic microalgae and liposomes have been conjugated to suppress autophagy and reduce hypoxia in cancer immunotherapy [ 336 ]. Regarding autophagy regulation, it should be highlighted that autophagy has a dual function in cancer and can exert carcinogenic and anti-carcinogenic functions, complicating its regulation in cancer therapy [ 337 , 338 ]. According to these studies, the regulation of hypoxia by nanoparticles can pave the new gate for cancer immunotherapy [ 339 – 342 ].…”

Section: Nanoparticles Targeting Tumor Microenvironment Components In...mentioning

confidence: 99%

Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

Lu,

Kou,

Lou

et al. 2024

J Hematol Oncol

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Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in the clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, and immune cells, plays a crucial role in immune response modulation. Nanoparticles, engineered to reshape the TME, have shown promising results in enhancing immunotherapy by facilitating targeted delivery and immune modulation. These nanoparticles can suppress fibroblast activation, promote M1 macrophage polarization, aid dendritic cell maturation, and encourage T cell infiltration. Biomimetic nanoparticles further enhance immunotherapy by increasing the internalization of immunomodulatory agents in immune cells such as dendritic cells. Moreover, exosomes, whether naturally secreted by cells in the body or bioengineered, have been explored to regulate the TME and immune-related cells to affect cancer immunotherapy. Stimuli-responsive nanocarriers, activated by pH, redox, and light conditions, exhibit the potential to accelerate immunotherapy. The co-application of nanoparticles with immune checkpoint inhibitors is an emerging strategy to boost anti-tumor immunity. With their ability to induce long-term immunity, nanoarchitectures are promising structures in vaccine development. This review underscores the critical role of nanoparticles in overcoming current challenges and driving the advancement of cancer immunotherapy and TME modification.

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“…Autophagy is a critical process in tumorigenesis with dual function in the tumorigenesis/cancer suppression. Since the certain role of autophagy in cancer has not been determined and it affects chemoresistance and tumorigenesis [ 56 , 57 ], its regulation by lncRNAs requires more investigation. In respect to abnormal expression of lncRNAs in cancers, they are implicated in process of carcinogenesis as inducers or inhibitors [ 58 ].…”

Section: Lncrnas In Oncologymentioning

confidence: 99%

Shedding light on function of long non-coding RNAs (lncRNAs) in glioblastoma

Hashemi,

Mousavian Roshanzamir,

Orouei

et al. 2024

Non-coding RNA Research

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A bioinformatics analysis, pre-clinical and clinical conception of autophagy in pancreatic cancer: Complexity and simplicity in crosstalk

Cited by 46 publications

References 201 publications

Reprogramming of lipid metabolism in the tumor microenvironment: a strategy for tumor immunotherapy

Reprogramming of lipid metabolism in the tumor microenvironment: a strategy for tumor immunotherapy

Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

Shedding light on function of long non-coding RNAs (lncRNAs) in glioblastoma

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