A bioengineered model for reinnervating the decellularized extracellular matrix of corneal scaffolds

Murtaza, Zoha F.; Abou Fares, Ali; AlMuhairi, Fatima; Paunovic, Jovana; Valjarevic, Svetlana; Pantic, Igor V.; Corridon, Peter R.

doi:10.1016/j.mehy.2024.111315

Medical Hypotheses

2024

DOI: 10.1016/j.mehy.2024.111315

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A bioengineered model for reinnervating the decellularized extracellular matrix of corneal scaffolds

Zoha F. Murtaza,

Ali Abou Fares,

Fatima AlMuhairi

et al.

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2024

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Cited by 3 publications

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Investigation of fatty acid profile of eyes recovered from slaughterhouse waste

Hachem,

Bermudez,

Ali

et al. 2024

Heliyon

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Investigation of fatty acid profile of eyes recovered from slaughterhouse waste

Hachem,

Bermudez,

Ali

et al. 2024

Heliyon

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A sustainable approach to derive sheep corneal scaffolds from stored slaughterhouse waste

Ali,

Wang,

Shibru

et al. 2024

Regenerative Medicine

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Aim: The escalating demand for corneal transplants significantly surpasses the available supply. To bridge this gap, we concentrated on ethical and sustainable corneal grafting sources. Our objective was to create viable corneal scaffolds from preserved slaughterhouse waste. Materials & methods: Corneas were extracted and decellularized from eyeballs that had been refrigerated for several days. These scaffolds underwent evaluation through DNA quantification, histological analysis, surface tension measurement, light propagation testing, and tensile strength assessment. Results: Both the native and acellular corneas (with ~90% DNA removed using a cost-effective and environmentally friendly surfactant) maintained essential optical and biomechanical properties for potential clinical use. Conclusion: Our method of repurposing slaughterhouse waste, stored at 4°C for several days, to develop corneal scaffolds offers a sustainable and economical alternative xenograft model.

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Sustainable varicose vein therapy using functionalized hydrogels derived solely from livestock waste

Corridon,

Ali,

Shibru

et al. 2024

Front. Sustain. Food Syst.

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Developing sustainable and effective treatments for chronic venous insufficiency (CVI) is crucial. In this study, we propose an innovative restorative approach utilizing hydrogels derived from the decellularized extracellular matrix (dECM) of cadaveric vascular tissues, adipose-derived stem cells (ADSCs), and gold nanoparticles (AuNPs). This therapeutic method leverages waste valorization by repurposing discarded cadaveric tissues from slaughterhouse livestock. The dECM hydrogels, enriched with ADSCs and AuNPs, offer a biocompatible scaffold that supports cellular differentiation and vascular integrity. Our approach addresses the limitations of current allo-, auto-, and xenograft methods by enhancing integration and functionality while potentially reducing costs through sustainable practices. This study explores functionalized hydrogel formulation solely generated from agri-food waste, gelation mechanisms, and preliminary cost-effectiveness, presenting a promising new avenue for treating early-stage varicose veins that can ultimately be translated to human models using discarded tissues.

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A bioengineered model for reinnervating the decellularized extracellular matrix of corneal scaffolds

Cited by 3 publications

References 35 publications

Investigation of fatty acid profile of eyes recovered from slaughterhouse waste

Investigation of fatty acid profile of eyes recovered from slaughterhouse waste

A sustainable approach to derive sheep corneal scaffolds from stored slaughterhouse waste

Sustainable varicose vein therapy using functionalized hydrogels derived solely from livestock waste

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