A biodegradable Zn-1Cu-0.1Ti alloy with antibacterial properties for orthopedic applications

Lin, Jixing; Tong, Xian; Shi, Zhanbiao; Zhang, Dechuang; Lishu, Zhang; Wang, Kun; Wei, Aiping; Jin, Lufan; Li, Yuncang; Wen, Cuie

doi:10.1016/j.actbio.2020.02.017

Cited by 135 publications

(97 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The HR alloy showed the best wear resistance. [ 152 ] Zn-0.8Mn-0.4Ca Melting at 725 °C with Ar gas protection + homogenization at 360 °C for 6 h followed by water quenched + HR at 100 °C with total 64% reduction in thickness. Hot rolling significantly refined Zn grains of Zn–Mn–Ca alloy from 289 to 5 μm and increased the σ TYS , σ UTS and ε from 112 to 245 MPa, 120–323 MPa and 0.3–12%, respectively.…”

Section: Fabrication and Post-thermomechanical Processing Of Zn-basedmentioning

confidence: 99%

“…For example, the σ UTS and ε of as-cast Zn–1Ca were concurrently enhanced from 165 MPa to 2.1% to 242 MPa and 7.7%, by HE, and to 252 MPa and 12.7% by HR, respectively [ 147 ]. Lin et al [ 152 ] also reported an improvement in the mechanical properties of as-cast Zn–1Cu-0.1Ti alloy by HR, in which the σ YTS , σ UTS and ε increased from 86 MPa, 92 MPa, and 1.4% to 175 MPa, 206 MPa, and 39.0%, respectively. It can be seen from the data listed in Table 5 that most of the Zn-based alloys fulfilling the mechanical benchmark criteria of biodegradable implant materials were processed via thermo-mechanical processing techniques including HE [ 153 ], HE + DW [ 151 ], and hydrostatic extrusion [ 154 ].…”

Section: Fabrication and Post-thermomechanical Processing Of Zn-basedmentioning

confidence: 99%

“…The tribological behavior of other Zn-based alloys for biomedical applications are rarely reported in the literature. Recently, Lin et al [ 152 ] reported the wear and friction behavior of as-cast, HR and cold rolled biodegradable Zn–1Cu-0.1Ti alloys with pure Zn as control and the results are shown in Fig. 13 .…”

Section: Tribological Properties Of Zn-alloysmentioning

confidence: 99%

See 2 more Smart Citations

Recent research and progress of biodegradable zinc alloys and composites for biomedical applications: Biomechanical and biocorrosion perspectives

Kabir

Munir

Wen

et al. 2021

Bioactive Materials

Self Cite

228

143

View full text Add to dashboard Cite

Biodegradable metals (BMs) gradually degrade in vivo by releasing corrosion products once exposed to the physiological environment in the body. Complete dissolution of biodegradable implants assists tissue healing, with no implant residues in the surrounding tissues. In recent years, three classes of BMs have been extensively investigated, including magnesium (Mg)-based, iron (Fe)-based, and zinc (Zn)-based BMs. Among these three BMs, Mg-based materials have undergone the most clinical trials. However, Mg-based BMs generally exhibit faster degradation rates, which may not match the healing periods for bone tissue, whereas Fe-based BMs exhibit slower and less complete in vivo degradation. Zn-based BMs are now considered a new class of BMs due to their intermediate degradation rates, which fall between those of Mg-based BMs and Fe-based BMs, thus requiring extensive research to validate their suitability for biomedical applications. In the present study, recent research and development on Zn-based BMs are reviewed in conjunction with discussion of their advantages and limitations in relation to existing BMs. The underlying roles of alloy composition, microstructure, and processing technique on the mechanical and corrosion properties of Zn-based BMs are also discussed.

show abstract

Section: Fabrication and Post-thermomechanical Processing Of Zn-basedmentioning

confidence: 99%

Section: Fabrication and Post-thermomechanical Processing Of Zn-basedmentioning

confidence: 99%

See 1 more Smart Citation

Recent research and progress of biodegradable zinc alloys and composites for biomedical applications: Biomechanical and biocorrosion perspectives

Kabir

Munir

Wen

et al. 2021

Bioactive Materials

Self Cite

228

143

View full text Add to dashboard Cite

show abstract

“…This increased antibacterial ability was due to the action of Fe, which accelerated alloy degradation to increase free Zn 2+ and Cu 2+ , which greatly enhanced antibacterial performance (Yue et al, 2020). Similarly, a Zn-1Cu-0.1Ti alloy exhibiting good antibacterial activity and mechanical properties was reported as a potent candidate for bone fracture fixation applications (Lin et al, 2020). However, its in vitro antibacterial effects were not fully reflected by the effects observed in vivo.…”

Section: Antibacterial Zn Alloymentioning

confidence: 99%

Recent Advances in Research on Antibacterial Metals and Alloys as Implant Materials

Jiao

Zhang

et al. 2021

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Implants are widely used in orthopedic surgery and are gaining attention of late. However, their use is restricted by implant-associated infections (IAI), which represent one of the most serious and dangerous complications of implant surgeries. Various strategies have been developed to prevent and treat IAI, among which the closest to clinical translation is designing metal materials with antibacterial functions by alloying methods based on existing materials, including titanium, cobalt, tantalum, and biodegradable metals. This review first discusses the complex interaction between bacteria, host cells, and materials in IAI and the mechanisms underlying the antibacterial effects of biomedical metals and alloys. Then, their applications for the prevention and treatment of IAI are highlighted. Finally, new insights into their clinical translation are provided. This review also provides suggestions for further development of antibacterial metals and alloys.

show abstract

“…Previous studies have also demonstrated that Zn–Cu alloys showed good antibacterial abilities towards Staphylococcus aureus ( S. aureus ) [ 28 , 29 , 75 ]. The detailed antibacterial mechanisms of Zn–Cu alloys is not completely understood but it is probably linked to the release of metallic ions (Zn 2+ and Cu 2+ ) and hydroxide ions (which increases the pH value).…”

Section: Discussionmentioning

confidence: 99%

Appropriately adapted properties of hot-extruded Zn–0.5Cu–xFe alloys aimed for biodegradable guided bone regeneration membrane application

Zhang

Li²,

Shen

et al. 2021

Bioactive Materials

View full text Add to dashboard Cite

Appropriately adapted comprehensive mechanical properties, degradation behavior and biocompatibility are prerequisites for the application of Zn-based biodegradable implants. In this study, hot-extruded Zn–0.5Cu–xFe (x = 0.1, 0.2 and 0.4 wt%) alloys were fabricated as candidates for biodegradable materials for guided bone regeneration (GBR) membranes. The hot-extrusion process and Cu alloying were expected mostly to enhance the mechanical properties, and the Fe alloying was added mainly for regulating the degradation. The microstructure, mechanical properties and in vitro degradation behavior were systematically investigated. The ZnCuFe alloys were composed of a Zn matrix and FeZn 13 phase. With increasing Fe content, a higher FeZn 13 phase precipitation with larger particles was observed. Since elongation declined significantly until fracture with increasing Fe content up to 0.4 wt%, the ZnCuFe (0.2 wt%) alloy achieved a good balance between mechanical strength and ductility, with an ultimate tensile strength of 202.3 MPa and elongation at fracture of 41.2%. Moreover, the addition of Fe successfully accelerated the degradation of ZnCuFe alloys. The ZnCuFe (0.2 wt%) alloy showed relatively uniform corrosion in the long-term degradation test. Furthermore, extracts of the ZnCuFe (0.2 wt%) alloy showed no apparent cytotoxic effects against L929 fibroblasts, Saos-2 osteoblasts or TAg periosteal cells. The ZnCuFe (0.2 wt%) alloy exhibited the potential to inhibit bacterial adhesion of Streptococcus gordonii and mixed oral bacteria. Our study provides evidence that the ZnCuFe (0.2 wt%) alloy can represent a promising material for the application as a suitable GBR membrane.

show abstract

A biodegradable Zn-1Cu-0.1Ti alloy with antibacterial properties for orthopedic applications

Cited by 135 publications

References 61 publications

Recent research and progress of biodegradable zinc alloys and composites for biomedical applications: Biomechanical and biocorrosion perspectives

Recent research and progress of biodegradable zinc alloys and composites for biomedical applications: Biomechanical and biocorrosion perspectives

Recent Advances in Research on Antibacterial Metals and Alloys as Implant Materials

Appropriately adapted properties of hot-extruded Zn–0.5Cu–xFe alloys aimed for biodegradable guided bone regeneration membrane application

Contact Info

Product

Resources

About