A Biodegradable Multifunctional Film as a Tissue Adhesive for Instant Hemostasis and Wound Closure

Abstract

Here, a multifunctional film (MFF) as an alternative tissue adhesive in the form of an interpenetrating network consisting of self‐crosslinked aldehyde‐functionalized chitosan (AC) and crosslinked poly(acrylic acid) (PAA) further coordinated with Ag+ is reported. The MFF combines enhanced toughness and stretchability, which is attributed to the synergistic effects of the double‐network design. Covalent crosslinking maintains the overall integrity of the MFF matrix, while noncovalent crosslinking dissipates energy under deformation. Upon contact, the MFF quickly dries the tissue surface followed by instant physical crosslinking to the tissue. Subsequent covalent crosslinking between the aldehyde groups of the MFF and the primary amine groups on the surface of the tissue further stabilizes the adhesion. Meanwhile, Ag+ provides strong antibacterial properties to the MFF. Notably, in vivo studies demonstrate that the MFF allows facile and tough attachment to the wet and dynamic surface of rabbit liver and presents superior hemostasis and sealing properties. Furthermore, the MFF can be safely degraded without causing abnormal defects in vivo. The outstanding physicochemical properties of the MFF can potentially be a good alternative to existing sutures or staples and has potential for use in clinical practice.

The effect of antimicrobial peptide HX‐12C on the properties of chitosan/polyacrylic acid hydrogel

“…Polyacrylic acid (PAA) is a degradable, biocompatible, and low‐cost weak anionic material that exhibits strong mechanical strength and water absorption capacity. It can be used to prepare pH‐sensitive hydrogels for drug delivery or wound dressing 12–14 . In the formulation, CS physically crosslinks with PAA through hydrogen bond between the amino group and the carboxyl group, along with electrostatic interaction facilitated by their opposite charges in aqueous solution 13,15 .…”

“…It can be used to prepare pHsensitive hydrogels for drug delivery or wound dressing. [12][13][14] In the formulation, CS physically crosslinks with PAA through hydrogen bond between the amino group and the carboxyl group, along with electrostatic interaction facilitated by their opposite charges in aqueous solution. 13,15 Several studies have reported the fabrication of high-performance hydrogels using CS and PAA as the skeleton material.…”

“…[12][13][14] In the formulation, CS physically crosslinks with PAA through hydrogen bond between the amino group and the carboxyl group, along with electrostatic interaction facilitated by their opposite charges in aqueous solution. 13,15 Several studies have reported the fabrication of high-performance hydrogels using CS and PAA as the skeleton material. For instance, Abdouss et al prepared curcumin-loaded nanoparticle using CS, PAA, and graphitic carbon nitride.…”