A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing

Gong, Changyang; Wu, Qinjie; Wang, Yujun; Zhang, Doudou; Luo, Feng; Zhao, Xia; Wei, Yuquan; Zhang, Qian

doi:10.1016/j.biomaterials.2013.05.005

Cited by 482 publications

(263 citation statements)

References 39 publications

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“…Since wounds are known to be deficient in nitric oxide, application of nitric oxidereleasing silica nanoparticles may accelerate healing by killing Journal of Nanotechnology 5 bacteria and overcoming the general nitric oxide deficiency [32]. Gong et al [33] have shown that when curcumin was loaded onto the lipophilic core of a polymeric micelle dispersed in a hydrogel, this formulation exhibited adequate tissue adhesiveness and could release curcumin in an extended time period. Studies carried out by Jeschke et al [34] and Pereira et al [35] have focused on the liposomal delivery of keratinocyte growth factor (KGF) which stimulates epithelial cell differentiation and proliferation, processes of major importance in wound healing.…”

Section: Nanoparticles/micelles/lipidsmentioning

confidence: 99%

A Review of Injectable and Implantable Biomaterials for Treatment and Repair of Soft Tissues in Wound Healing

Chou

Gunaseelan

Kiellani

et al. 2017

Journal of Nanotechnology

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The two major topics concerning the development of nanomedicine are drug delivery and tissue engineering. With the advance in nanotechnology, scientists and engineers now have the ability to fabricate functional drug carriers and/or biomaterials that deliver and release drugs locally as well as promote tissue regeneration. In this short review, we address the use of nanotechnology in the fabrication of biomaterials (i.e., nanoparticles and nanofibers) and their therapeutic function in wound healing as dressing materials. Furthermore, we discuss the use of surface nanofeatures to regulate cell adhesion, migration, proliferation, and differentiation, which is a crucial step in wound healing associated with tissue regeneration. Given that nanotechnology-based biomaterials exhibit superior pharmaceutical performance as compared to the traditional medicine, this short review provides current status and future directions of how nanotechnology is and will be used in biomedical field, especially in wound healing.

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Section: Nanoparticles/micelles/lipidsmentioning

confidence: 99%

A Review of Injectable and Implantable Biomaterials for Treatment and Repair of Soft Tissues in Wound Healing

Chou

Gunaseelan

Kiellani

et al. 2017

Journal of Nanotechnology

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“…The release medium was PBS pH 7.4 containing 1% (v/v) Tween® 80 which is a low molecular weight non-ionic surfactant that can be added to release media to maintain sink conditions for hydrophobic drugs [40,41]. Curcumin solubility in the release medium was 240.8 μg/mL confirming the maintenance of sink conditions during the release experiment given the release volume (20 mL) and curcumin amounts in the micelles (100-200 μg).…”

Section: In Vitro Curcumin Release From a 2 B Miktoarm Micellesmentioning

confidence: 99%

Miktoarm Star Micelles Containing Curcumin Reduce Cell Viability of Sensitized Glioblastoma

Soliman¹

2014

J Nanomedine Biotherapeutic Discov

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Glioblastoma multiforme (GBM) is the most common and lethal primary intracranial tumor in humans. Monotherapeutic interventions have not been successful. The objective of the current studies was to establish the effective combination therapy consisting of pifitrin as a sensitizer, and curcumin as therapeutic incorporated into miktoarm micelles. A 2 B type miktoarm stars were prepared using a combination of click chemistry with ring opening polymerization on a core with orthogonal functionalities. These self-assemble into spherical micelles with hydrophobic core and hydrophilic corona structure. Micellar delivery systems for curcumin based on these miktoarm star polymers were prepared, characterized and tested on cultures sensitized with pifitrin. The results show that: (1) pifitrin and temozolamide in combination with curcumin cause significant cell death compared with the individual therapeutics (incorporated or not in micelles), and (2) repeated exposure to the same treatments is necessary to fully prevent a re-growth of glioblastoma cells both in 2D and 3D cultures. Although the incorporation of curcumin into A 2 B star polymer micelles did not increase the extent of cell death compared with curcumin alone, the advantage of micelles is that they significantly increase the aqueous solubility of curcumin and sustain its release; this will likely reduce the frequency of its administration required to be effective in vivo. A 2 B miktoarm polymers could be a new viable delivery system for curcumin and other anticancer drugs with similar limitations.

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“…Wound healing components are tested as solutions, gels and ointments or in more complex wound care structures (e.g. hydrogel systems 8,9 ).…”

Section: Introductionmentioning

confidence: 99%

Models for the study of skin wound healing. The role of Nrf2 and NF-κB

Ambrožová¹,

Ulrichová²,

Galandáková³

2017

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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a,bNrf2 and NF-κB transcription factors act in wound healing via their anti-inflammatory and anti-oxidant effects or through the immune response. Studying this process is a matter of some importance given the high cost of wound treatment. A major contribution in this regard is being made by models that enable investigation of the involvement of multiple factors in wound healing and testing new curative substances. This literature review was carried out via searches in the PubMed and Web of Science databases up to 2016. It covers skin wound healing, available models for its study (part I), the role of Nrf2 and NF-κB, substances that influence them and whether they can be used as markers (part II). Was found that in vitro assays are used for their availability but a holistic view must be established in vivo. In silico approaches are facilitating assessment of a vast amount of research data. Nfr2 and NF-κB play a crucial and reciprocal role in wound healing. Nrf2 controls repair-associated inflammation and protects against excessive accumulation of ROS while Nf-κB activates the innate immune reaction, proliferation and migration of cells, modulates expression of matrix metalloproteinases, secretion and stability of cytokines and growth factors for wound healing.

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A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing

Cited by 482 publications

References 39 publications

A Review of Injectable and Implantable Biomaterials for Treatment and Repair of Soft Tissues in Wound Healing

A Review of Injectable and Implantable Biomaterials for Treatment and Repair of Soft Tissues in Wound Healing

Miktoarm Star Micelles Containing Curcumin Reduce Cell Viability of Sensitized Glioblastoma

Models for the study of skin wound healing. The role of Nrf2 and NF-κB

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