A biocompatible gelatin sponge scaffold confers robust tissue remodeling after spinal cord injury in a non-human primate model

Zeng, Xiang; Wei, Qing-shuai; Ye, Ji-chao; Rao, Jingjing; Zheng, Miaoyan; Ma, Yuan-Huan; Peng, Lizhi; Ding, Ying; Lai, Bi-Qin; Li, Ge; Cheng, Shixiang; Ling, Alexander; Han, Inbo; Zeng, Yuan-Shan

doi:10.1016/j.biomaterials.2023.122161

Cited by 4 publications

(2 citation statements)

References 56 publications

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“…Gelatin sponges can also serve as part of drug delivery systems by embedding drugs into the sponge, enabling slow and sustained release suitable for treating certain conditions that require long-term therapy. 176 The application scope of gelatin sponge scaffolds is extremely broad, based on the biocompatibility and degradability of gelatin. Ribatti et al proposed a method to quantify angiogenesis and antiangiogenesis in the chorioallantoic membrane (CAM) of chicken embryos by implanting gelatin sponges on the top of the growing CAM at the eighth day of development.…”

Section: Applications Of Gelatin Of Micro/nanostructures In Therapeut...mentioning

confidence: 99%

“…Due to their water-absorbing capacity and shape-memory properties, gelatin sponges can quickly adsorb blood and form clots, assisting in hemostasis. Gelatin sponges can also serve as part of drug delivery systems by embedding drugs into the sponge, enabling slow and sustained release suitable for treating certain conditions that require long-term therapy …”

Section: Applications Of Gelatin Of Micro/nanostructures In Therapeut...mentioning

confidence: 99%

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Chemical and Structural Engineering of Gelatin-Based Delivery Systems for Therapeutic Applications: A Review

Jia,

Fan,

Chen

et al. 2024

Biomacromolecules

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As a biodegradable and biocompatible protein derived from collagen, gelatin has been extensively exploited as a fundamental component of biological scaffolds and drug delivery systems for precise medicine. The easily engineered gelatin holds great promise in formulating various delivery systems to protect and enhance the efficacy of drugs for improving the safety and effectiveness of numerous pharmaceuticals. The remarkable biocompatibility and adjustable mechanical properties of gelatin permit the construction of active 3D scaffolds to accelerate the regeneration of injured tissues and organs. In this Review, we delve into diverse strategies for fabricating and functionalizing gelatin-based structures, which are applicable to gene and drug delivery as well as tissue engineering. We emphasized the advantages of various gelatin derivatives, including methacryloyl gelatin, polyethylene glycolmodified gelatin, thiolated gelatin, and alendronate-modified gelatin. These derivatives exhibit excellent physicochemical and biological properties, allowing the fabrication of tailor-made structures for biomedical applications. Additionally, we explored the latest developments in the modulation of their physicochemical properties by combining additive materials and manufacturing platforms, outlining the design of multifunctional gelatin-based micro-, nano-, and macrostructures. While discussing the current limitations, we also addressed the challenges that need to be overcome for clinical translation, including high manufacturing costs, limited application scenarios, and potential immunogenicity. This Review provides insight into how the structural and chemical engineering of gelatin can be leveraged to pave the way for significant advancements in biomedical applications and the improvement of patient outcomes.

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Section: Applications Of Gelatin Of Micro/nanostructures In Therapeut...mentioning

confidence: 99%

Section: Applications Of Gelatin Of Micro/nanostructures In Therapeut...mentioning

confidence: 99%

Chemical and Structural Engineering of Gelatin-Based Delivery Systems for Therapeutic Applications: A Review

Jia,

Fan,

Chen

et al. 2024

Biomacromolecules

View full text Add to dashboard Cite

show abstract

Functional biomaterials for modulating the dysfunctional pathological microenvironment of spinal cord injury

Ma,

Fu,

et al. 2024

Bioactive Materials

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An integrated long-acting implant of clinical safe cells, drug and biomaterials effectively promotes spinal cord repair and restores motor functions

Li,

Mu,

Chen

et al. 2024

Journal of Controlled Release

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A biocompatible gelatin sponge scaffold confers robust tissue remodeling after spinal cord injury in a non-human primate model

Cited by 4 publications

References 56 publications

Chemical and Structural Engineering of Gelatin-Based Delivery Systems for Therapeutic Applications: A Review

Chemical and Structural Engineering of Gelatin-Based Delivery Systems for Therapeutic Applications: A Review

Functional biomaterials for modulating the dysfunctional pathological microenvironment of spinal cord injury

An integrated long-acting implant of clinical safe cells, drug and biomaterials effectively promotes spinal cord repair and restores motor functions

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